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المؤلفون: Lukas Tamayo-Orrego, Samer Salameh, Grant W. Brown, Andrew P. Jackson, David Gallo, Sushmetha Mohan, Frédéric Racicot, Trang Hoang, Brandon Ho, Amandine Bemmo, Frédéric Charron
المساهمون: Université de Montréal. Faculté de médecine. Département de médecine
المصدر: Nature Cancer
Tamayo Orrego, L, Gallo, D, Racicot, F, Bemmo, A, Mohan, S, Ho, B, Salameh, S, Hoang, T, Jackson, A P, Brown, G W & Charron, F 2020, ' Sonic hedgehog accelerates DNA replication to cause replication stress promoting cancer initiation in medulloblastoma ', nature cancer . https://doi.org/10.1038/s43018-020-0094-7Testمصطلحات موضوعية: DNA Replication, Cancer Research, animal structures, Carcinogenesis, Tumor initiation, Biology, medicine.disease_cause, Loss of heterozygosity, Mice, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Hedgehog Proteins, Homologous recombination, Sonic hedgehog, Cancer models, Cerebellar Neoplasms, Cancer, 030304 developmental biology, Medulloblastoma, 0303 health sciences, DNA replication, Origin firing, medicine.disease, Cell biology, CNS cancer, Oncology, PTCH1, embryonic structures, biology.protein, 030217 neurology & neurosurgery
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e4d4c4af099fd7b9ffa5fbc117c5f4aTest
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المؤلفون: Frédéric Charron, Lukas Tamayo-Orrego
المصدر: F1000Research
مصطلحات موضوعية: tumor progression, Tumor initiation, Review, General Biochemistry, Genetics and Molecular Biology, law.invention, Metastasis, 03 medical and health sciences, Mice, 0302 clinical medicine, law, Cerebellum, medicine, Tumor Microenvironment, Animals, Humans, Hedgehog Proteins, General Pharmacology, Toxicology and Pharmaceutics, Sonic hedgehog, Cerebellar Neoplasms, neoplasms, 030304 developmental biology, Progenitor, Medulloblastoma, 0303 health sciences, Tumor microenvironment, General Immunology and Microbiology, biology, business.industry, General Medicine, Articles, medicine.disease, 3. Good health, nervous system diseases, stomatognathic diseases, Tumor progression, cell senescence, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Suppressor, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5755cf5c04b15270443ab6d7369e74dTest
https://pubmed.ncbi.nlm.nih.gov/31700613Test -
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المؤلفون: Frédéric Charron, Shannon M. Swikert, Lukas Tamayo-Orrego
المصدر: Cell Cycle
مصطلحات موضوعية: 0301 basic medicine, Senescence, Genome instability, preneoplasia, medicine.disease_cause, Loss of heterozygosity, sonic hedgehog, 03 medical and health sciences, Ptch1, medicine, Animals, Humans, Hedgehog Proteins, TP53, Sonic hedgehog, neoplasms, Molecular Biology, Cellular Senescence, Genetics, Medulloblastoma, Extra Views, biology, p53, Cell Biology, medicine.disease, Hedgehog signaling pathway, nervous system diseases, stomatognathic diseases, 030104 developmental biology, PTCH1, cell senescence, Mutation, Cancer research, biology.protein, Tumor Suppressor Protein p53, Carcinogenesis, Signal Transduction, Developmental Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5dc10099687a4223936d0c2abd20d41Test
https://doi.org/10.1080/15384101.2016.1189044Test -
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المؤلفون: David Gallo, Lukas Tamayo-Orrego, Grant W. Brown, Frédéric Charron, Samer Salameh, Amandine Bemmo, Frédéric Racicot, Sushmetha Mohan
المصدر: Neuro-Oncology. 21:ii113-ii113
مصطلحات موضوعية: Genome instability, Cancer Research, Mutation, animal structures, biology, DNA damage, DNA replication, Cancer, PTCH1 Gene, medicine.disease_cause, medicine.disease, chemistry.chemical_compound, Oncology, chemistry, embryonic structures, Cancer research, medicine, biology.protein, Neurology (clinical), Sonic hedgehog, DNA, Medulloblastoma
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5715fcbf750a981dc2369e8270294e2Test
https://doi.org/10.1093/neuonc/noz036.204Test -
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المؤلفون: Frédéric Charron
المصدر: PLoS Genetics
PLoS Genetics, Vol 11, Iss 9, p e1005441 (2015)مصطلحات موضوعية: Cancer Research, Cell signaling, lcsh:QH426-470, Endosome, Endocytic cycle, Nerve Tissue Proteins, Biology, Endocytosis, Retinal ganglion, Genetics, Animals, Receptors, Immunologic, Molecular Biology, Genetics (clinical), Ecology, Evolution, Behavior and Systematics, Body Patterning, Slit, Axons, Cell biology, Intracellular signal transduction, lcsh:Genetics, Perspective, Axon guidance, Drosophila, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f3c746a87513b4711ccab040036560fTest
https://pubmed.ncbi.nlm.nih.gov/26334304Test -
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المؤلفون: Lukas Tamayo-Orrego, Chia-Lun Wu, Frédéric Charron, Nicolas Bouchard, Patryk Skowron, Michael D. Taylor, Marc Remke, Ahmed Khedher, Shannon M. Swikert
المصدر: Cell Reports, Vol 14, Iss 12, Pp 2925-2937 (2016)
مصطلحات موضوعية: 0301 basic medicine, p53, p16ink4a, Somatic cell, Cell, Loss of Heterozygosity, Kaplan-Meier Estimate, Loss of heterozygosity, Mice, CDKN2A, Cerebellum, Sonic hedgehog, Promoter Regions, Genetic, lcsh:QH301-705.5, Cellular Senescence, biology, Brain Neoplasms, Immunohistochemistry, 3. Good health, Patched-1 Receptor, ptch1, medicine.anatomical_structure, Disease Progression, Senescence, endocrine system, Ultraviolet Rays, Mutation, Missense, preneoplasia, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, sonic hedgehog, medicine, Animals, Humans, Hedgehog Proteins, neoplasms, Cyclin-Dependent Kinase Inhibitor p16, Medulloblastoma, DNA Methylation, medicine.disease, Mice, Inbred C57BL, stomatognathic diseases, 030104 developmental biology, PTCH1, lcsh:Biology (General), Microscopy, Fluorescence, biology.protein, Cancer research, Tumor Suppressor Protein p53
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7dd7194d126dc1e65ccd00317cad60ecTest
https://pubmed.ncbi.nlm.nih.gov/26997276Test -
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المؤلفون: Molly R. Marous, Andrew M. Overmiller, D.M. Brennan-Crispi, Felicia Cooper, My G. Mahoney, Julio C. Salas-Alanis, N.A. Riobo-Del Galdo, Frédéric Charron, Kathleen P. McGuinn, Joya Sahu, Lukas Tamayo-Orrego, Sarah E. Millar
المصدر: Journal of Investigative Dermatology. 136:S14
مصطلحات موضوعية: Tumor microenvironment, business.industry, Cell Biology, Dermatology, medicine.disease, medicine.disease_cause, Biochemistry, Metastasis, Tumor progression, Cancer research, Medicine, Tumor promotion, Neoplastic transformation, Keratinocyte migration, Skin cancer, business, Carcinogenesis, Molecular Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::21dda6ade3394f1d284010ce81bdd4c4Test
https://doi.org/10.1016/j.jid.2016.02.104Test -
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المؤلفون: Chantal Lefebvre, Frédéric Charron, Mona Nemer, Kevin M. McBride
المصدر: Oncogene. 22(52)
مصطلحات موضوعية: Genetics, Cancer Research, ATF3, biology, GATA2, Promoter, c-Fos, DNA-binding protein, Precipitin Tests, Cell biology, GATA4 Transcription Factor, Rats, DNA-Binding Proteins, biology.protein, Transcriptional regulation, GATA transcription factor, Animals, Molecular Biology, Transcription factor, Proto-Oncogene Proteins c-fos, Transcription Factors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd9af617e414719a46eada98faf1deeTest
https://pubmed.ncbi.nlm.nih.gov/14627981Test -
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المؤلفون: Mona Nemer, Qiangrong Liang, Mathieu Arcand, Frédéric Charron, Lynda Robitaille, Sylvain Meloche, Jeffery D. Molkentin, George Tsimiklis
المصدر: Genesdevelopment. 15(20)
مصطلحات موضوعية: Sarcomeres, RHOA, Blotting, Western, Fluorescent Antibody Technique, GTPase, p38 Mitogen-Activated Protein Kinases, Adenoviridae, Mediator, Genetics, Phosphoprotein Phosphatases, Humans, Small GTPase, Promoter Regions, Genetic, Transcription factor, Cells, Cultured, In Situ Hybridization, Regulation of gene expression, biology, Endothelin-1, Myocardium, Promoter, DNA, Actin cytoskeleton, Blotting, Northern, Cell biology, GATA4 Transcription Factor, DNA-Binding Proteins, Enhancer Elements, Genetic, Gene Expression Regulation, Cancer research, biology.protein, RNA, Mitogen-Activated Protein Kinases, rhoA GTP-Binding Protein, Developmental Biology, Transcription Factors, Research Paper
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1144c84153b45e0795f43ff09fe54d36Test
https://pubmed.ncbi.nlm.nih.gov/11641276Test -
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المؤلفون: Frédéric Charron, Michael D. Taylor, Luisa Izzi, Marc Remke, Martin Lévesque, Lukas Tamayo-Orrego, Frédéric Mille, Paul A. Northcott, Andrey Korshunov, Marcel Kool, Stefan M. Pfister, Nicolas Bouchard, Julie Cardin
المصدر: Developmental Cell. (1):34-47
مصطلحات موضوعية: Patched Receptors, animal structures, DNA damage, Receptors, Cell Surface, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Mice, 0302 clinical medicine, Downregulation and upregulation, Neural Stem Cells, medicine, Animals, Humans, Cyclin D1, Hedgehog Proteins, Sonic hedgehog, Receptor, Cerebellar Neoplasms, Molecular Biology, neoplasms, 030304 developmental biology, Cell Proliferation, Medulloblastoma, 0303 health sciences, biology, Cell growth, Cell Biology, medicine.disease, Up-Regulation, nervous system diseases, Mice, Inbred C57BL, Patched-1 Receptor, stomatognathic diseases, PTCH1, 030220 oncology & carcinogenesis, Immunoglobulin G, Immunology, embryonic structures, Cancer research, biology.protein, Signal transduction, Developmental Biology, DNA Damage, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8969d70879f11c9fbf71748ec6296268Test