المؤلفون: Shanade Dunn, Cath Eberlein, Jason Yu, Albert Gris-Oliver, Swee Hoe Ong, Urs Yelland, Natalie Cureton, Anna Staniszewska, Robert McEwen, Millie Fox, James Pilling, Philip Hopcroft, Elizabeth A. Coker, Patricia Jaaks, Mathew J. Garnett, Beverley Isherwood, Violeta Serra, Barry R. Davies, Simon T. Barry, James T. Lynch, Kosuke Yusa

المساهمون: Institut Català de la Salut, [Dunn S] Wellcome Sanger Institute, Cambridge, UK. Bioscience, Early Oncology, AstraZeneca, Cambridge, UK. [Eberlein C, Yelland U] Bioscience, Early Oncology, AstraZeneca, Alderley Park, UK. [Yu J] Wellcome Sanger Institute, Cambridge, UK. Molecular Biology of Metabolism Lab, The Francis Crick Institute, London, UK. [Gris-Oliver A, Serra V] Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Ong SH] Wellcome Sanger Institute, Cambridge, UK, Vall d'Hebron Barcelona Hospital Campus

المصدر: Scientia

مصطلحات موضوعية: Cancer Research, Physiological Phenomena::Pharmacological and Toxicological Phenomena::Pharmacological Phenomena::Drug Resistance::Drug Resistance, Neoplasm [PHENOMENA AND PROCESSES], Class I Phosphatidylinositol 3-Kinases, Neoplasms::Neoplasms by Site::Breast Neoplasms [DISEASES], Medicaments antineoplàstics - Ús terapèutic, Otros calificadores::Otros calificadores::/farmacoterapia [Otros calificadores], Breast Neoplasms, Antineoplastic Agents, Mechanistic Target of Rapamycin Complex 1, Other subheadings::Other subheadings::/drug therapy [Other subheadings], Phosphatidylinositol 3-Kinases, Cell Line, Tumor, Genetics, Humans, Guanine Nucleotide Exchange Factors, Other subheadings::/therapeutic use [Other subheadings], Protein Kinase Inhibitors, Molecular Biology, Phosphoinositide-3 Kinase Inhibitors, Resistència als medicaments, fenómenos fisiológicos::fenómenos farmacológicos y toxicológicos::fenómenos farmacológicos::resistencia a medicamentos::resistencia a los antineoplásicos [FENÓMENOS Y PROCESOS], neoplasias::neoplasias por localización::neoplasias de la mama [ENFERMEDADES], Otros calificadores::/uso terapéutico [Otros calificadores], TOR Serine-Threonine Kinases, PTEN Phosphohydrolase, acciones y usos químicos::acciones farmacológicas::usos terapéuticos::antineoplásicos [COMPUESTOS QUÍMICOS Y DROGAS], Mama - Càncer - Tractament, Female, Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antineoplastic Agents [CHEMICALS AND DRUGS], Proto-Oncogene Proteins c-akt

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a9e136f779ccbe55fa005a37d201d30Test
https://hdl.handle.net/11351/8698Test

المؤلفون: Paul Kinchesh, James M Thompson, Stuart Gilchrist, Barry R. Davies, Jennifer L. Martin, Mark J. O'Connor, Veerle Kersemans, Sean Smart, Yanyan Jiang, Anderson J. Ryan, Kay Shigemori, Maryam Alkadhimi, Mark A. Hill

المصدر: British Journal of Cancer

مصطلحات موضوعية: Thorax, Cancer Research, Radiation-Sensitizing Agents, Lung Neoplasms, Article, Piperazines, Olaparib, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Therapeutic index, Carcinoma, Non-Small-Cell Lung, medicine, Animals, Lung cancer, Cancer models, 030304 developmental biology, 0303 health sciences, medicine.diagnostic_test, Radiotherapy, business.industry, Magnetic resonance imaging, Histology, medicine.disease, Disease Models, Animal, Therapeutic Index, Treatment Outcome, Oncology, chemistry, Tolerability, 030220 oncology & carcinogenesis, Toxicity, Phthalazines, Female, business, Nuclear medicine, Non-small-cell lung cancer

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e600d6088887f3370444bc9ed4771b5bTest
http://europepmc.org/articles/PMC8144220Test

المؤلفون: Shenghua Wen, Srividya B. Balachander, Francis D. Gibbons, Michael Zinda, William McCoull, Nancy Su, Barry R. Davies, Stephen E. Kurtz, Terry MacIntyre, Edward J. Hennessy, Martin Wild, Paula Lewis, Ricky W. Johnstone, Jamal Carlos Saeh, Kathleen A. Burke, Omid Tavana, Andrea Newbold, Elizabeth A. Coker, Alwin Schuller, Justin Cidado, Diebold R Bruce, Tristan J. Lubinski, Steven Criscione, J. Paul Secrist, Kate Byth, Gareth P. Gregory, Deborah Lawson, Ammar Adam, Shannon K. McWeeney, Stephen Fawell, Thomas Gero, Jeffrey G. Varnes, Eric Gangl, Patricia Jaaks, Jeffrey W. Tyner, Mathew J. Garnett, Areya Tabatabai, Stephanos Ioannidis

المصدر: Clinical Cancer Research. 26:6535-6549

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, biology, Venetoclax, Chronic lymphocytic leukemia, Cancer, Myeloid leukemia, Bcl-xL, medicine.disease, 3. Good health, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, 0302 clinical medicine, medicine.anatomical_structure, Oncology, chemistry, In vivo, Apoptosis, 030220 oncology & carcinogenesis, biology.protein, medicine, Cancer research, B cell

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::564420d79c6feacf9af617f03b6937bcTest
https://doi.org/10.1158/1078-0432.ccr-20-0863Test

المؤلفون: Kyoko Nakamura, Neil H. James, Paul Farrington, Ankur Karmokar, Susan J. Bickerton, Simon J. Dovedi, Gareth Hughes, Timothy M Illidge, Elaine Cadogan, Antonio Ramos-Montoya, Barry R. Davies, Viia Valge-Archer

المصدر: Nakamura, K, Karmokar, A, Farrington, P M, James, N H, Ramos-Montoya, A, Bickerton, S J, Hughes, G D, Illidge, T M, Cadogan, E B, Davies, B R, Dovedi, S J & Valge-Archer, V 2021, ' Inhibition of DNA-PK with AZD7648 Sensitizes Tumor Cells to Radiotherapy and Induces Type I IFN-Dependent Durable Tumor Control ', Clinical cancer research : an official journal of the American Association for Cancer Research, vol. 27, no. 15, pp. 4353-4366 . https://doi.org/10.1158/1078-0432.CCR-20-3701Test

مصطلحات موضوعية: Cancer Research, Tumor microenvironment, Radiation-Sensitizing Agents, Combination therapy, Manchester Cancer Research Centre, Chemistry, DNA damage, ResearchInstitutes_Networks_Beacons/mcrc, DNA Repair Pathway, DNA-Activated Protein Kinase, Triazoles, Non-homologous end joining, Granzyme B, Mice, Immune system, Oncology, Purines, Cell Line, Tumor, Neoplasms, Interferon Type I, Cancer research, Animals, Protein Kinase Inhibitors, CD8, Pyrans

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::361b99c301898bba1de98f81587a182cTest
https://research.manchester.ac.uk/en/publications/08e42339-29d6-407b-83fc-396678da590eTest

المؤلفون: Kunzah Jamal, Anna Staniszewska, Jacob Gordon, Shenghua Wen, Frank McGrath, Gregory Dowdell, Dominic Kabbabe, Giuditta illuzzi, Matthew Griffin, Barry R. Davies, Petra Hamerlik

المصدر: Cancer Research. 82:2609-2609

مصطلحات موضوعية: Cancer Research, Oncology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::728e8f30b4670d6c50328eb487e60996Test
https://doi.org/10.1158/1538-7445.am2022-2609Test

المؤلفون: Thomas B.K. Watkins, James A. Hall, Charles Swanton, Carlos Caldas, Carolin M. Sauer, Barry R. Davies, Helen Bolton, Peter Baldwin, Sabina Cosulich, Maria Vias, Matthew D. Eldridge, Karen Hosking, Dominique-Laurent Couturier, James D. Brenton, Mercedes Jimenez-Linan, Robin Crawford, Krishnayan Haldar, Larissa S. Carnevalli, Ines de Santiago, Filipe C. Martins, Kevin Litchfield, Gabriel Funingana, Bristi Basu, Gerard I. Evan, John Latimer, Anna M. Piskorz, Iain A. McNeish, Anumithra Amirthanayagam, Deborah A. Sanders, Mihaela Angelova, Sohrab P. Shah, Nicholas McGranahan

مصطلحات موضوعية: Somatic cell, business.industry, Context (language use), mTORC1, Genome, Clinical trial, chemistry.chemical_compound, Paclitaxel, chemistry, Cancer research, Medicine, business, Gene, PI3K/AKT/mTOR pathway

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6831132d62db72d2fba321990edc2300Test
https://doi.org/10.1101/2020.10.04.325365Test

المؤلفون: David J. Arenillas, Peter C.K. Leung, Wyeth W. Wasserman, Nelly Auersperg, Arezoo Astanehe, Gordon B. Mills, Sandra E. Dunn, Barry R. Davies

المصدر: Journal of Cell Science. 133

مصطلحات موضوعية: Blot, medicine.anatomical_structure, Transcription (biology), Cell, medicine, Cancer research, Cell Biology, Biology, Ovarian cancer, medicine.disease, Epithelium

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1ca9f942acc81045f383c7a989f7c9fcTest
https://doi.org/10.1242/jcs.253260Test

المؤلفون: Mark J. O'Connor, Stephen Fawell, Barry R. Davies, Joanne Wilson, Valeria Follia, Paul W. G. Wijnhoven, M. Raymond V. Finlay, Mercedes Vazquez-Chantada, Neil H. James, Elaine Cadogan, Aaron Smith, Paul Farrington, Simon J. Hollingsworth, Lenka Oplustil O'Connor, Emma Dean, Ankur Karmokar, Sophie E. Willis, Frederick W. Goldberg, Gillian M. Lamont, Antonio Ramos-Montoya, Stephanie Ling, D. Beattie, Jacqueline H. L. Fok, Jonathan Cairns, Jenni Nikkilä

المصدر: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

مصطلحات موضوعية: 0301 basic medicine, Genome instability, Lung Neoplasms, General Physics and Astronomy, Apoptosis, DNA-Activated Protein Kinase, Radiation Tolerance, Piperazines, Polyethylene Glycols, chemistry.chemical_compound, Mice, 0302 clinical medicine, Carcinoma, Non-Small-Cell Lung, lcsh:Science, Multidisciplinary, Antibiotics, Antineoplastic, Drug Synergism, 030220 oncology & carcinogenesis, PARP inhibitor, Growth inhibition, medicine.symptom, Clinical pharmacology, DNA damage, Science, Drug development, Poly(ADP-ribose) Polymerase Inhibitors, General Biochemistry, Genetics and Molecular Biology, Article, Genomic Instability, Olaparib, 03 medical and health sciences, Cell Line, Tumor, medicine, Animals, Humans, Protein kinase A, Protein Kinase Inhibitors, Cell Proliferation, Pyrans, Radiotherapy, General Chemistry, Triazoles, Xenograft Model Antitumor Assays, 030104 developmental biology, chemistry, Mechanism of action, A549 Cells, Doxorubicin, Purines, Cancer research, Phthalazines, lcsh:Q

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e2343caeeb96aedc19f4ab9d664878eTest
http://europepmc.org/articles/PMC6838110Test

المؤلفون: Fara Brasó-Maristany, Mònica Sánchez-Guixé, Andreu Ódena, Aleix Prat, Olga Rodriguez, Yasir H. Ibrahim, Alejandra Bruna, Elza C. de Bruin, Barry R. Davies, Alan Barnicle, Laia Monserrat, Judit Grueso, Carlos Caldas, Guillermo Villacampa, Nicholas C. Turner, Avinash Reddy, Paolo Nuciforo, Albert Gris-Oliver, Joaquín Arribas, Violeta Serra, Gordon B. Mills, Maurizio Scaltriti, Caroline S. Hirst, Mafalda Oliveira, Gaia Schiavon, Cristina Saura, Marta Guzman, Marta Palafox, Pedram Razavi, Mireia Parés, Rodrigo Dienstmann

المصدر: Clin Cancer Res

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Paclitaxel, Class I Phosphatidylinositol 3-Kinases, DNA Mutational Analysis, AKT1, P70-S6 Kinase 1, Breast Neoplasms, Tuberous Sclerosis Complex 1 Protein, Article, 03 medical and health sciences, Mice, 0302 clinical medicine, Breast cancer, Antineoplastic Combined Chemotherapy Protocols, medicine, Biomarkers, Tumor, PTEN, Animals, Humans, Pyrroles, Breast, Protein kinase B, Protein Kinase Inhibitors, PI3K/AKT/mTOR pathway, Mastectomy, biology, Fulvestrant, business.industry, TOR Serine-Threonine Kinases, Ribosomal Protein S6 Kinases, 70-kDa, medicine.disease, Prognosis, Metastatic breast cancer, Xenograft Model Antitumor Assays, 030104 developmental biology, Pyrimidines, Oncology, Chemotherapy, Adjuvant, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Mutation, biology.protein, Cancer research, Female, business, Proto-Oncogene Proteins c-akt, medicine.drug, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef93ddf12491d1bbf7d5667c25fa96d7Test
https://pubmed.ncbi.nlm.nih.gov/32220884Test

المؤلفون: A. Robert MacLeod, Kazuhiro Yoshikawa, Kazuko Sakai, Youngsoo Kim, Hayley Campbell, Koichi Sugimoto, Stephanie Klein, Marco A. De Velasco, Yurie Kura, Barry R. Davies, Yuji Hatanaka, Hirotsugu Uemura, Kazuto Nishio

المصدر: JCI Insight. 4

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.drug_class, Antineoplastic Agents, Castration resistant, urologic and male genital diseases, Antiandrogen, Mice, Phosphatidylinositol 3-Kinases, 03 medical and health sciences, Prostate cancer, 0302 clinical medicine, Pharmacotherapy, Antisense Oligonucleotide Therapy, Animals, Humans, Medicine, Pyrroles, Protein kinase B, PI3K/AKT/mTOR pathway, Mice, Knockout, business.industry, Prostatic Neoplasms, General Medicine, Oligonucleotides, Antisense, medicine.disease, Gene Expression Regulation, Neoplastic, Mice, Inbred C57BL, Androgen receptor, Disease Models, Animal, Prostatic Neoplasms, Castration-Resistant, Pyrimidines, 030104 developmental biology, Drug Resistance, Neoplasm, Receptors, Androgen, 030220 oncology & carcinogenesis, Cancer research, Transcriptome, business, Proto-Oncogene Proteins c-akt, Research Article, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa8cf2bddeac4732db473566c0ff7ec1Test
https://doi.org/10.1172/jci.insight.122688Test