دورية أكاديمية
The Revelation of Continuously Organized, Co-Overexpressed Protein-Coding Genes with Roles in Cellular Communications in Breast Cancer
| العنوان: | The Revelation of Continuously Organized, Co-Overexpressed Protein-Coding Genes with Roles in Cellular Communications in Breast Cancer |
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| المؤلفون: | Paul, Aswathy Mary, Amjesh, Revikumar, George, Bijesh, Sankaran, Deivendran |
| المصدر: | Open Access Archive |
| بيانات النشر: | Impressions@MAHE |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | breast cancer, cancer progression, computational biology, coregulation, emerging pathways, polygenic nature, shared mechanisms of gene expression, transcriptome |
| الوصف: | Many human cancers, including breast cancer, are polygenic and involve the co-dysregulation of multiple regulatory molecules and pathways. Though the overexpression of genes and amplified chromosomal regions have been closely linked in breast cancer, the notion of the co-upregulation of genes at a single locus remains poorly described. Here, we describe the co-overexpression of 34 continuously organized protein-coding genes with diverse functions at 8q.24.3(143437655-144326919) in breast and other cancer types, the CanCord34 genes. In total, 10 out of 34 genes have not been reported to be overexpressed in breast cancer. Interestingly, the overexpression of CanCord34 genes is not necessarily associated with genomic amplification and is independent of hormonal or HER2 status in breast cancer. CanCord34 genes exhibit diverse known and predicted functions, including enzymatic activities, cell viability, multipotency, cancer stem cells, and secretory activities, including extracellular vesicles. The co-overexpression of 33 of the CanCord34 genes in a multivariant analysis was correlated with poor survival among patients with breast cancer. The analysis of the genome-wide RNAi functional screening, cell dependency fitness, and breast cancer stem cell databases indicated that three diverse overexpressed CanCord34 genes, including a component of spliceosome PUF60, a component of exosome complex EXOSC4, and a ribosomal biogenesis factor BOP1, shared roles in cell viability, cell fitness, and stem cell phenotypes. In addition, 17 of the CanCord34 genes were found in the microvesicles (MVs) secreted from the mesenchymal stem cells that were primed with MDA-MB-231 breast cancer cells. Since these MVs were important in the chemoresistance and dedifferentiation of breast cancer cells into cancer stem cells, these findings highlight the significance of the CanCord34 genes in cellular communications. In brief, the persistent co-overexpression of CanCord34 genes with diverse functions can lead to the dysregulation of ... |
| نوع الوثيقة: | text |
| اللغة: | unknown |
| العلاقة: | https://impressions.manipal.edu/open-access-archive/3641Test |
| DOI: | 10.3390/cells11233806 |
| الإتاحة: | https://doi.org/10.3390/cells11233806Test https://impressions.manipal.edu/open-access-archive/3641Test |
| رقم الانضمام: | edsbas.522507D4 |
| قاعدة البيانات: | BASE |
| DOI: | 10.3390/cells11233806 |
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