التفاصيل البيبلوغرافية
| العنوان: |
miR-935 suppresses gastric signet ring cell carcinoma tumorigenesis by targeting Notch1 expression. |
| المؤلفون: |
Yan, Chao1, Yu, Jianchun1 yu_jchpumch@163.com, Kang, Weiming1, Liu, Yuqin2, Ma, Zhiqiang1, Zhou, Li1 |
| المصدر: |
Biochemical & Biophysical Research Communications. Jan2016, Vol. 470 Issue 1, p68-74. 7p. |
| مصطلحات موضوعية: |
*MICRORNA, *CARCINOGENESIS, *NOTCH proteins, *CANCER invasiveness, *CANCER diagnosis, *GENETICS, *STOMACH cancer, *THERAPEUTICS, *PROGNOSIS |
| مستخلص: |
Gastric signet ring cell carcinoma (GSRCC) is a unique pathological type of gastric carcinoma that is extremely invasive and has a poor prognosis. Expression of microRNAs (miRNAs) has been closely linked to the carcinogenesis of gastric cancer and has been considered as a powerful prognostic marker. The function of miR-935 has never been reported in cancer before. We found, using microRNA array, that expression of miR-935 in GSRCC cell lines is lower than in non-GSRCC cell lines, and enhanced expression of miR-935 in GSRCC cell-lines inhibit cell proliferation, migration and invasion. We also identified Notch1 as a direct target of miR-935. Knockdown of Notch1 reduced proliferation, migration/invasion of GSRCC cells, and overexpression Notch1's activated form (Notch intracellular domain) could rescue miR-935's tumor suppressive effect on GSRCC. Expression of miR-935 was lower in gastric carcinoma tissue than in paired normal tissue samples, and lower in GSRCC than in non-GSRCC. Our results demonstrate the inverse correlation between the expression of miR-935 and Notch1 in gastric tissues. We conclude that miR-935 inhibits gastric carcinoma cell proliferation, migration and invasion by targeting Notch1, suggesting potential applications of the miR-935-Notch1 pathway in gastric cancer clinical diagnosis and therapeutics, especially in gastric signet ring cell carcinoma. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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