التفاصيل البيبلوغرافية
| العنوان: |
S-Adenosyl-l-Methionine Overcomes uL3-Mediated Drug Resistance in p53 Deleted Colon Cancer Cells. |
| المؤلفون: |
Mosca, Laura, Pagano, Martina, Pecoraro, Annalisa, Borzacchiello, Luigi, Mele, Luigi, Cacciapuoti, Giovanna, Porcelli, Marina, Russo, Giulia, Russo, Annapina |
| المصدر: |
International Journal of Molecular Sciences; Jan2021, Vol. 22 Issue 1, p103, 1p |
| مصطلحات موضوعية: |
DRUG resistance in cancer cells, DRUG resistance, CANCER cells, COLON cancer, CELL cycle, P53 antioncogene |
| مستخلص: |
Purpose: In order to study novel therapeutic approaches taking advantage of natural compounds showing anticancer and anti-proliferative effects, we focused our interest on S-adenosyl-l-methionine, a naturally occurring sulfur-containing nucleoside synthesized from adenosine triphosphate and methionine by methionine adenosyltransferase, and its potential in overcoming drug resistance in colon cancer cells devoid of p53. Results: In the present study, we demonstrated that S-adenosyl-l-methionine overcomes uL3-mediated drug resistance in p53 deleted colon cancer cells. In particular, we demonstrated that S-adenosyl-l-methionine causes cell cycle arrest at the S phase; inhibits autophagy; augments reactive oxygen species; and induces apoptosis in these cancer cells. Conclusions: Results reported in this paper led us to propose S-adenosyl-l-methionine as a potential promising agent for cancer therapy by examining p53 and uL3 profiles in tumors to yield a better clinical outcomes. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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