التفاصيل البيبلوغرافية
| العنوان: |
Synthesis of Selenium-Quinone Hybrid Compounds with Potential Antitumor Activity via Rh-Catalyzed C-H Bond Activation and Click Reactions. |
| المؤلفون: |
Jardim, Guilherme A. M., da Cruz, Eduardo H. G., Valença, Wagner O., Lima, Daisy J. B., Cavalcanti, Bruno C., Pessoa, Claudia, Rafique, Jamal, Braga, Antonio L., Jacob, Claus, da Silva Júnior, Eufrânio N. |
| المصدر: |
Molecules; Jan2018, Vol. 23 Issue 1, p83, 16p, 6 Diagrams, 1 Chart |
| مصطلحات موضوعية: |
SELENIUM, NAPHTHOQUINONE, CLICK chemistry, CANCER chemotherapy, CANCER cells, THERAPEUTICS |
| مستخلص: |
In continuation of our quest for new redox-modulating catalytic antitumor molecules, selenium-containing quinone-based 1,2,3-triazoles were synthesized using rhodium-catalyzed C-H bond activation and click reactions. All compounds were evaluated against five types of cancer cell lines: HL-60 (human promyelocytic leukemia cells), HCT-116 (human colon carcinoma cells), SF295 (human glioblastoma cells), NCIH-460 (human lung cells) and PC3 (human prostate cancer cells). Some compounds showed good activity with IC50 values below 1 µM. The cytotoxic potential of the naphthoquinoidal derivatives was also evaluated in non-tumor cells, exemplified by L929 cells. Overall, these compounds represent promising new lead derivatives and stand for a new class of chalcogenium-containing derivatives with potential antitumor activity. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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