TFDP3 as E2F Unique Partner, Has Crucial Roles in Cancer Cells and Testis
| العنوان: | TFDP3 as E2F Unique Partner, Has Crucial Roles in Cancer Cells and Testis |
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| المؤلفون: | Ming Chu, Jinlong Liu, Yini Wang, Yuedan Wang, Jiahao Huang |
| المصدر: | Frontiers in Oncology, Vol 11 (2021) Frontiers in Oncology |
| بيانات النشر: | Frontiers Media SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, TFDP3, CT30, E2F-1, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Review, pocket proteins, Biology, Cell biology, Transduction (genetics), Oncology, Antigen, HCA661, Cancer cell, Cytotoxic T cell, Cancer/testis antigens, Transcription factor DP, DP4, cancer-testis antigen, RB, E2F, Gene, RC254-282 |
| الوصف: | Transcription factor DP family member 3 (TFDP3) is a cancer-testis antigen, mainly expressed in normal testis and multiple cancers.TFDP3gene (Gene ID: 51270) is located on the chromosome X and shares a high degree of sequence homology with TFDP1 and TFDP2, which can form heterodimers with E2F family members and enhance DNA-binding activity of E2Fs. In contrast to TFDP1 and TFDP2, TFDP3 downregulates E2F-mediated transcriptional activation. During DNA damage response in cancer cells, TFDP3 is induced and can inhibit E2F1-mediated apoptosis. Moreover, TFDP3 is involved in cell autophagy and epithelial-mesenchymal transition. Regarding cancer therapy opportunity, the transduction of dendritic cells with recombinant adenovirus-encoding TFDP3 can activate autologous cytotoxic T lymphocytes to target hepatoma cells. Here, we review the characterization of TFDP3, with an emphasis on the biological function and molecular mechanism. A better understanding of TFDP3 will provide new insights into the pathological mechanisms and therapeutic strategies for cancers. |
| تدمد: | 2234-943X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cedaf9e38780f63e3869d95366862417Test https://doi.org/10.3389/fonc.2021.742462Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....cedaf9e38780f63e3869d95366862417 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2234943X |
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