دورية أكاديمية
Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases
| العنوان: | Demographic and disease-related factors impact bone turnover and vitamin D in children with hemato-oncological diseases |
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| المؤلفون: | Jackmann, Natalja, Gustafsson, Jan, Utriainen, Pauliina, Magnusson, Per, Harila, Arja, Atanasova, Diana, Rinaldo, Carina, Frisk, Per, Mäkitie, Outi |
| بيانات النشر: | Uppsala universitet, Barnonkologisk forskning - särskilt fokus pÃ¥ komplikationer Uppsala universitet, Pediatrisk inflammations- och metabolismforskning samt barnhälsa Uppsala universitet, Barnonkologisk och neurologisk forskning Univ Childrens Hosp, S-75185 Uppsala, Sweden |
| سنة النشر: | 2024 |
| المجموعة: | Uppsala University: Publications (DiVA) |
| مصطلحات موضوعية: | biochemical markers of bone turnover: bone modeling and remodeling, tumor-induced bone disease: cancer, other: diseases and disorders of/related to bone, Pediatrics, Pediatrik, Cancer and Oncology, Cancer och onkologi, Hematology, Hematologi |
| الوصف: | Children with hemato-oncological diseases may have significant skeletal morbidity, not only during and after treatment but also at the time of diagnosis before cancer treatment. This study was designed to evaluate the vitamin D status and circulating bone metabolic markers and their determinants in children at the time of diagnostic evaluation for hemato-oncological disease. This cross-sectional study included 165 children (91 males, median age 6.9 yr range 0.2–17.7 yr). Of them, 76 patients were diagnosed with extracranial or intracranial solid tumors, 83 with leukemia, and 6 with bone marrow failure. Bone metabolism was assessed by measuring serum 25OHD, PTH, bone alkaline phosphatase, intact N-terminal propeptide of type I procollagen, and C-terminal cross-linked telopeptide of type I collagen. Vitamin D deficiency was found in 30.9% of children. Lower 25OHD levels were associated with older age, lack of vitamin D supplementation, season outside summer, and a country of parental origin located between latitudes −45° and 45°. Children diagnosed with leukemia had lower levels of markers of bone formation and bone resorption than those who had solid tumors or bone marrow failure. In conclusion, vitamin D deficiency was observed in one-third of children with newly diagnosed cancer. Bone turnover markers were decreased in children with leukemia, possibly because of the suppression of osteoblasts and osteoclasts by leukemic cells. The identification of patients with suboptimal vitamin D status and compromised bone remodeling at cancer diagnosis may aid in the development of supportive treatment to reduce the adverse effects of cancer and its treatment. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | 2024, 8:4; JBMR Plus, 2024, 8:4; orcid:0000-0003-2817-3299; orcid:0000-0002-7540-438x; orcid:0000-0003-2767-5828; orcid:0000-0002-4547-001X; http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-527482Test; PMID 38523666; ISI:001203149800001 |
| DOI: | 10.1093/jbmrpl/ziae017 |
| الإتاحة: | https://doi.org/10.1093/jbmrpl/ziae017Test http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-527482Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.D6FAD211 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/jbmrpl/ziae017 |
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