التفاصيل البيبلوغرافية
| العنوان: |
Facile surface functional polyetheretherketone with antibacterial and immunoregulatory activities for enhanced regeneration toward bacterium-infected bone destruction |
| المؤلفون: |
An’an Sun (11217618), Xi Lin (212839), Zhiqiang Xue (5531093), Jiyue Huang (121495), Xinxin Bai (11217621), Lingling Huang (1429468), Xinhua Lin (538781), Shaohuang Weng (11217624), Min Chen (147733) |
| سنة النشر: |
2021 |
| المجموعة: |
Smithsonian Institution: Digital Repository |
| مصطلحات موضوعية: |
Medicine, Microbiology, Biotechnology, Cancer, Plant Biology, Space Science, Chemical Sciences not elsewhere classified, Physical Sciences not elsewhere classified, Co-deposition of polydopamine and gentamicin, PEEK, anti-infection, immunoregulatory, enhanced osseintegration |
| الوصف: |
Existing biologically inert or unmodified implants to treat infectious bone defects or osteomyelitis still cannot effectively solve bacterial infection and osseointegration. In this work, a simple co-deposition strategy was developed to modify porous polyetheretherketone (PEEK) with improved antibacterial activity and controllable immunoregulatory ability. After PEEK was treated by H 2 SO 4 to obtain porous PEEK (SPEEK), the self-polymerization of dopamine was operated on SPEEK in the solution of dopamine and gentamicin sulfate (GS) to prepare polydopamine (pDA) and GS layer-modified SPEEK (labeled as SPEEK–pDA–GS). The morphology, surface property, and molecular structure of SPEEK–pDA–GS were investigated. Besides the antibacterial property of SPEEK–pDA–GS ascribed to the successful immobilization of GS, SPEEK–pDA–GS exhibited promoted osseointegration through the results of mineralization, alkaline phosphatase (ALP) levels and osteogenic gene expression. Furthermore, the evaluation of the cell proliferation suggested that SPEEK–pDA–GS possessed the biocompatibility and the immunoregulatory ability that induced macrophages to anti-inflammatory M2 phenotype. Using rat as model, in vivo results containing X-ray, μ-CT, immunohistochemistry, and pathological analysis showed the excellent healing effect of SPEEK–pDA–GS on bone defect with infection with biological safety. This work illustrates a new insight into the simple and effective modification of PEEK and other implants with antibacterial, immunoregulatory, and osseointegration abilities for clinical requirement. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
https://figshare.com/articles/journal_contribution/Facile_surface_functional_polyetheretherketone_with_antibacterial_and_immunoregulatory_activities_for_enhanced_regeneration_toward_bacterium-infected_bone_destruction/15090780Test |
| DOI: |
10.6084/m9.figshare.15090780.v1 |
| الإتاحة: |
https://doi.org/10.6084/m9.figshare.15090780.v1Test |
| حقوق: |
CC BY 4.0 |
| رقم الانضمام: |
edsbas.3EAE531D |
| قاعدة البيانات: |
BASE |
