المؤلفون: Jost, Marco, Chen, Yuwen, Gilbert, Luke A, Horlbeck, Max A, Krenning, Lenno, Menchon, Grégory, Rai, Ankit, Cho, Min Y, Stern, Jacob J, Prota, Andrea E, Kampmann, Martin, Akhmanova, Anna, Steinmetz, Michel O, Tanenbaum, Marvin E, Weissman, Jonathan S

المصدر: Molecular Cell. 68(1)

مصطلحات موضوعية: Biological Sciences, Biotechnology, Human Genome, Genetics, Orphan Drug, Cancer, Rare Diseases, Aetiology, Development of treatments and therapeutic interventions, 2.1 Biological and endogenous factors, 5.1 Pharmaceuticals, Antineoplastic Agents, CRISPR-Cas Systems, Colchicine, Drug Resistance, Neoplasm, Gene Expression Regulation, Neoplastic, Genetic Testing, Genetic Vectors, Glycine, HeLa Cells, Humans, K562 Cells, Kinesins, Lentivirus, Microtubules, Mutation, Myelodysplastic Syndromes, RNA, Guide, Kinetoplastida, Recombinant Fusion Proteins, Small Molecule Libraries, Sulfones, Tubulin, Tubulin Modulators, Vinblastine, Hela Cells, CRISPRa, CRISPRi, chemical genetics, drug mechanism of action, drug target identification, genome-wide CRISPR screening, microtubules, rigosertib, Medical and Health Sciences, Developmental Biology, Biological sciences, Biomedical and clinical sciences, Health sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/1d37n4k6Test

المؤلفون: Wieczorek, Michal, Tcherkezian, Joseph, Bernier, Cynthia, Prota, Andrea E, Chaaban, Sami, Rolland, Yannève, Godbout, Claude, Hancock, Mark A, Arezzo, Joseph C, Ocal, Ozhan, Rocha, Cecilia, Olieric, Natacha, Hall, Anita, Ding, Hui, Bramoullé, Alexandre, Annis, Matthew G, Zogopoulos, George, Harran, Patrick G, Wilkie, Thomas M, Brekken, Rolf A, Siegel, Peter M, Steinmetz, Michel O, Shore, Gordon C, Brouhard, Gary J, Roulston, Anne

المصدر: Science Translational Medicine. 8(365)

مصطلحات موضوعية: Neurosciences, Cancer, Neurodegenerative, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Animals, Antineoplastic Agents, Cell Line, Tumor, Crystallography, X-Ray, Dimerization, Genomics, Humans, Lactams, Macrocyclic, Mice, Microscopy, Electron, Microtubules, Mitosis, Neoplasm Transplantation, Neurons, Oxazoles, Tubulin, Vinblastine, Vinca Alkaloids, Vinorelbine, Biological Sciences, Medical and Health Sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9dr6h535Test

المؤلفون: Cury, Nathália Moreno, Mühlethaler, Tobias, Laranjeira, Angelo Brunelli Albertoni, Canevarolo, Rafael Renatino, Zenatti, Priscila Pini, Lucena-Agell, Daniel, Barasoain, Isabel, Song, Chunhua, Sun,Dongxiao, Dovat, Sinisa, Yunes, Rosendo Augusto, Prota, Andrea E., Steinmetz, Michel O., Díaz, José Fernando, Yunes, José Andrés

المساهمون: Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Ministerio de Economía y Competitividad (España), Swiss National Science Foundation, University of Pennsylvania, Cury, Nathália Moreno, Zenatti, Priscila Pini, Lucena-Agell, Daniel, Barasoain, Isabel, Song, Chunhua, Dovat, Sinisa, Yunes, Rosendo Augusto, Prota, Andrea E., Steinmetz, Michel O., Díaz, José Fernando

مصطلحات موضوعية: Biological sciences, Cancer, Drugs, Molecular Biology, Structural Biology

العلاقة: #PLACEHOLDER_PARENT_METADATA_VALUE#; info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-75319-R; Publisher's version; https://doi.org/10.1016/j.isci.2019.10.003Test; Sí; iScience 21:95-109 (2019); http://hdl.handle.net/10261/196704Test; http://dx.doi.org/10.13039/501100001807Test; http://dx.doi.org/10.13039/501100003593Test; http://dx.doi.org/10.13039/100006920Test; http://dx.doi.org/10.13039/501100003329Test

الإتاحة: https://doi.org/10.1016/j.isci.2019.10.003Test
https://doi.org/10.13039/501100001807Test
https://doi.org/10.13039/501100003593Test
https://doi.org/10.13039/100006920Test
https://doi.org/10.13039/501100003329Test
http://hdl.handle.net/10261/196704Test

المؤلفون: Zisterer, Daniela, O'Sullivan, Jeffrey, Brindisi, Margherita, Ulivieri, Cristina, Alfano, Gloria, Gemma, Sandra, de As?s Balaguer, Francisco, Khan, Tuhina, Grillo, Alessandro, Chemi, Giulia, Menchon, Gr?gory, Prota, Andrea E., Olieric, Natacha, Lucena-Agell, Daniel, Barasoain, Isabel, Fernando Diaz, J., Nebbioso, Angela, Conte, Mariarosaria, Lopresti, Ludovica, Magnano, Stefania, Amet, Rebecca, Kinsella, Paula, Ibrahim, Ola, Morbidelli, Lucia, Spaccapelo, Roberta, Baldari, Cosima, Butini, Stefania, Novellino, Ettore, Campiani, Giuseppe, Altucci, Lucia, Steinmetz, Michel O., Brogi, Simone

مصطلحات موضوعية: Pyrrolonaphthoxazepines, Structural studies, Microtubule-targeting agent, Apoptosis, Antitumor agents, Tubulin, X-ray crystallography, Molecular modeling, Cancer

وصف الملف: 290-320

العلاقة: European Journal of Medicinal Chemistry; info:eu-repo/grantAgreement/EC/FP7/CM1407; info:eu-repo/grantAgreement/EC/FP7/EPICHEMBIO CM-1406; Brindisi, M., Ulivieri, C., Alfano, G., Gemma, S., de As?s Balaguer, F., Khan, T., Grillo, A., Chemi, G., Menchone, G., Prota, A.E., Olieric, N., Lucena-Agell, D., Barasoain, I., Fernando Diaz, J., Nebbiosa, A., Conte, M., Lopresti, L., Magnano, S., Amet, R., Kinsella, P., Zisterer, D.M., Ibrahim, O., O'Sullivan, J., Morbidelli, L., Spaccapelo, R., Baldari, C., Butini, S., Novellino, E., Campiani, G., Altucci, L., Steinmetz, M.O. & Brogi, S., Structure-activity relationships, biological evaluation and structural studies of novel pyrrolonaphthoxazepines as antitumor agents, European Journal of Medicinal Chemistry, 2019, 290-320; Y; https://www.sciencedirect.com/science/article/pii/S0223523418309528?via%3DihubTest; http://hdl.handle.net/2262/91222Test; http://people.tcd.ie/dzistrerTest; http://people.tcd.ie/josulliTest; 193055; http://dx.doi.org/10.1016/j.ejmech.2018.11.004Test; https://doi.org/10.1016/j.ejmech.2018.11.004Test; orcid:0000-0001-5005-1023

الإتاحة: https://doi.org/10.1016/j.ejmech.2018.11.004Test
http://hdl.handle.net/2262/91222Test
https://www.sciencedirect.com/science/article/pii/S0223523418309528?via%3DihubTest
http://people.tcd.ie/dzistrerTest
http://people.tcd.ie/josulliTest

المؤلفون: Canela, María-Dolores, Noppen, Sam, Bueno, Oskía, Prota, Andrea E., Bargsten, Katja, Sáez-Calvo, Gonzalo, Jimeno, María-Luisa, Benkheil, Mohammed, Ribatti, Domenico, Velázquez, Sonsoles, Camarasa, María-José, Fernando Díaz, J., Steinmetz, Michel O., Priego, Eva-María, Pérez-Pérez, María-Jesús, Liekens, Sandra

المساهمون: Canela, María-Dolore, Noppen, Sam, Bueno, Oskía, Prota, Andrea E., Bargsten, Katja, Sáez-Calvo, Gonzalo, Jimeno, María-Luisa, Benkheil, Mohammed, Ribatti, Domenico, Velázquez, Sonsole, Camarasa, María-José, Fernando Díaz, J., Steinmetz, Michel O., Priego, Eva-María, Pérez-Pérez, María-Jesú, Liekens, Sandra

مصطلحات موضوعية: Cancer, Drug research, Tubulin, Vascular-disrupting, Angiogenesis Inhibitor, Animal, Antineoplastic Agent, Apoptosi, Benzodioxole, Binding Site, Breast Neoplasm, Cell Movement, Cell Proliferation, Cells, Cultured, Chalcone, Crystallography, X-Ray, Dipeptide, Endothelium, Vascular, Female, Human, Melanoma, Experimental, Mice, SCID, Neovascularization, Pathologic, Prodrug

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/27224920; volume:8; issue:9; firstpage:14325; lastpage:14342; numberofpages:18; journal:ONCOTARGET; http://hdl.handle.net/11586/228005Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85014070318; http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&pathTest[]=9527&path[]=29775

الإتاحة: https://doi.org/10.18632/oncotarget.9527Test
http://hdl.handle.net/11586/228005Test
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=download&pathTest[]=9527&path[]=29775

المؤلفون: Canela, María-Dolores, Noppen, Sam, Bueno, Oskía, Prota, Andrea E., Bargsten, Katja, Sáez-Calvo, Gonzalo, Jimeno, M. Luisa, Benkhei, Mohammed, Ribatti, Domenico, Velázquez, Sonsoles, Camarasa Rius, María José, Díaz, José Fernando, Steinmetz, Michel O., Priego, Eva María, Peréz-Pérez, María-Jesús, Liekens, Sandra

المساهمون: Ministerio de Economía y Competitividad (España), Comunidad de Madrid, Swiss National Science Foundation

مصطلحات موضوعية: Cancer, Drug research, Tubulin, Vascular-disrupting

العلاقة: http://dx.doi.org/10.18632/oncotarget.9527Test; Sí; Oncotarget, Advance Publication (2016); http://hdl.handle.net/10261/138212Test; http://dx.doi.org/10.13039/501100003329Test; http://dx.doi.org/10.13039/100012818Test

الإتاحة: https://doi.org/10.18632/oncotarget.9527Test
https://doi.org/10.13039/501100003329Test
https://doi.org/10.13039/100012818Test
http://hdl.handle.net/10261/138212Test

المؤلفون: Jost, Marco, Chen, Yuwen, Gilbert, Luke A, Horlbeck, Max A, Krenning, Lenno, Menchon, Grégory, Rai, Ankit, Cho, Min Y, Stern, Jacob J, Prota, Andrea E, Kampmann, Martin, Akhmanova, Anna, Steinmetz, Michel O., Tanenbaum, Marvin E, Weissman, Jonathan S, Sub Cell Biology, Celbiologie

المساهمون: Hubrecht Institute for Developmental Biology and Stem Cell Research, Sub Cell Biology, Celbiologie

المصدر: Molecular Cell, 68(1), 210. Cell Press
Molecular Cell
Molecular Cell, 68(1), 210-223.e6. Cell Press
Molecular cell, vol 68, iss 1

مصطلحات موضوعية: 0301 basic medicine, Drug Resistance, Kinesins, Medical and Health Sciences, Microtubules, Tubulin, 2.1 Biological and endogenous factors, RNA, Guide, Sulfones, Kinetoplastida, Aetiology, Cancer, Genetics, Gene knockdown, rigosertib, Rigosertib, Kinesin, Biological Sciences, drug mechanism of action, Tubulin Modulators, 3. Good health, Gene Expression Regulation, Neoplastic, chemical genetics, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Chemical genetics, RNA, Guide, Kinetoplastida, Biotechnology, Recombinant Fusion Proteins, Genetic Vectors, Glycine, Antineoplastic Agents, Computational biology, Biology, Vinblastine, Article, Small Molecule Libraries, microtubules, 03 medical and health sciences, CRISPRa, Rare Diseases, Microtubule, Journal Article, Humans, Genetic Testing, Molecular Biology, drug target identification, Neoplastic, Human Genome, Lentivirus, CRISPRi, Cell Biology, genome-wide CRISPR screening, Orphan Drug, 030104 developmental biology, Gene Expression Regulation, Drug Resistance, Neoplasm, Myelodysplastic Syndromes, Mutation, biology.protein, Neoplasm, RNA, CRISPR-Cas Systems, Colchicine, K562 Cells, Guide, Developmental Biology, HeLa Cells, Genetic screen

وصف الملف: image/pdf; application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f179af91573489aafc58613822af4048Test

المؤلفون: Isabel Barasoain, Nathalia Moreno Cury, José Andrés Yunes, Andrea E. Prota, Dongxiao Sun, Chunhua Song, Priscila Pini Zenatti, Tobias Mühlethaler, Sinisa Dovat, Angelo Brunelli Albertoni Laranjeira, Daniel Lucena-Agell, Rosendo A. Yunes, Michel O. Steinmetz, Rafael Renatino Canevarolo, José Fernando Díaz

المساهمون: Fundação de Amparo à Pesquisa do Estado de São Paulo, Conselho Nacional de Desenvolvimento Científico e Tecnológico (Brasil), Ministerio de Economía y Competitividad (España), Swiss National Science Foundation, University of Pennsylvania, Cury, Nathália Moreno [0000-0002-1749-812X], Zenatti, Priscila Pini [0000-0002-8662-7458], Lucena-Agell, Daniel [0000-0001-7198-2900], Barasoain, Isabel [0000-0003-2013-085X], Song, Chunhua [0000-0001-7563-0339], Dovat, Sinisa [0000-0003-3906-6165], Yunes, Rosendo Augusto [0000-0002-4529-5733], Prota, Andrea E. [0000-0003-0875-5339], Steinmetz, Michel O. [0000-0001-6157-3687], Díaz, José Fernando [0000-0003-2743-3319], Cury, Nathália Moreno, Zenatti, Priscila Pini, Lucena-Agell, Daniel, Barasoain, Isabel, Song, Chunhua, Dovat, Sinisa, Yunes, Rosendo Augusto, Prota, Andrea E., Steinmetz, Michel O., Díaz, José Fernando

المصدر: iScience
iScience, Vol 21, Iss, Pp 95-109 (2019)
Digital.CSIC. Repositorio Institucional del CSIC
instname

مصطلحات موضوعية: 0301 basic medicine, ATP-binding cassette transporter, 02 engineering and technology, macromolecular substances, Pharmacology, Article, 03 medical and health sciences, chemistry.chemical_compound, Structural Biology, medicine, Colchicine, lcsh:Science, Molecular Biology, Cancer, Multidisciplinary, biology, Therapeutic effect, Drugs, Cell cycle, Biological Sciences, 021001 nanoscience & nanotechnology, medicine.disease, 3. Good health, Multiple drug resistance, Biological sciences, 030104 developmental biology, Tubulin, chemistry, Mechanism of action, biology.protein, lcsh:Q, medicine.symptom, 0210 nano-technology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0bb83c0d7ffcebf6ee1c2439a6bd23Test
https://pubmed.ncbi.nlm.nih.gov/31655259Test