نتائج البحث - "Blake T. Aftab"

1

Potent Activity of an Anti-ICAM1 Antibody–Drug Conjugate against Multiple Myeloma

المؤلفون: Daniel W. Sherbenou, Thomas G. Martin, Olivia Perez De Acha, Byron Hann, Blake T. Aftab, Megan Murnane, Yang Su, Jeffery L. Wolf, Shelby C. Bearrows, Bin Liu, Christopher R. Behrens

المصدر: Clinical cancer research : an official journal of the American Association for Cancer Research, vol 26, iss 22
Clin Cancer Res

مصطلحات موضوعية: Male, 0301 basic medicine, Cancer Research, Immunoconjugates, medicine.medical_treatment, Mice, 0302 clinical medicine, hemic and lymphatic diseases, Monoclonal, Multiple myeloma, Cancer, Tumor, Antibodies, Monoclonal, Hematology, Middle Aged, Intercellular Adhesion Molecule-1, Flow Cytometry, Antibodies, Anti-Idiotypic, Anti-Idiotypic, medicine.anatomical_structure, Oncology, 5.1 Pharmaceuticals, 030220 oncology & carcinogenesis, Heterografts, Female, Development of treatments and therapeutic interventions, Multiple Myeloma, Biotechnology, Adult, Antibody-drug conjugate, medicine.drug_class, Oncology and Carcinogenesis, Monoclonal antibody, Article, Antibodies, Cell Line, 03 medical and health sciences, Rare Diseases, Clinical Research, In vivo, Cell Line, Tumor, medicine, Animals, Humans, Oncology & Carcinogenesis, Cell Proliferation, Aged, business.industry, Daratumumab, Immunotherapy, medicine.disease, ADP-ribosyl Cyclase 1, Orphan Drug, 030104 developmental biology, Cancer research, Bone marrow, business, Ex vivo

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c90915ca7c606383916fa2bf8e189cbTest
https://doi.org/10.1158/1078-0432.ccr-20-0400Test

2

Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment

المؤلفون: Hui Liu, Yu Hsiu T. Lin, Megan Murnane, Geoffrey A. Smith, Christine Lam, Margarette C. Mariano, Arun P. Wiita, Jack Taunton, Sandy W. Wong, Jun O. Liu, Constantine S. Mitsiades, Blake T. Aftab, Ian Ferguson, Byron Hann

المصدر: Haematologica, vol 103, iss 7
Haematologica

مصطلحات موضوعية: 0301 basic medicine, Proteomics, Ruxolitinib, Proteome, Cell Communication, Cardiorespiratory Medicine and Haematology, Plasma Cell Disorders, chemistry.chemical_compound, Mice, Piperidines, Bone Marrow, Tumor Microenvironment, 2.1 Biological and endogenous factors, Medicine, Aetiology, Cancer, Hematology, 3. Good health, STAT Transcription Factors, medicine.anatomical_structure, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, Multiple Myeloma, medicine.drug, Signal Transduction, Stromal cell, Plasma Cells, Immunology, Article, 03 medical and health sciences, Rare Diseases, In vivo, Animals, Humans, Pyrroles, Protein Kinase Inhibitors, Janus Kinases, Tumor microenvironment, Tofacitinib, 5.2 Cellular and gene therapies, business.industry, Venetoclax, Animal, Mesenchymal stem cell, Drug Repositioning, Mesenchymal Stem Cells, Phosphoproteins, Xenograft Model Antitumor Assays, Disease Models, Animal, Orphan Drug, 030104 developmental biology, Pyrimidines, chemistry, Disease Models, Cancer research, Bone marrow, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d3bb91b64a9c4e0fbaed43ab5969e84Test
https://escholarship.org/uc/item/99g7601fTest

3

Validation of the Hsp70–Bag3 Protein–Protein Interaction as a Potential Therapeutic Target in Cancer

المؤلفون: Jennifer N. Rauch, Bryan M. Dunyak, Byron Hann, Peter Walter, Martin Kampmann, Megan Murnane, Min Cho, Xiaokai Li, Teresa A. Colvin, Jason E. Gestwicki, Diego Acosta-Alvear, Blake T. Aftab, Jonathan S. Weissman, Michael Y. Sherman

المصدر: Molecular cancer therapeutics, vol 14, iss 3

مصطلحات موضوعية: Cyclin-Dependent Kinase Inhibitor p21, Cancer Research, Oncology and Carcinogenesis, Allosteric regulation, Antineoplastic Agents, Pharmacology, BAG3, Article, Cell Line, Protein–protein interaction, Mice, Cell Line, Tumor, Proliferating Cell Nuclear Antigen, 2.1 Biological and endogenous factors, Animals, Humans, HSP70 Heat-Shock Proteins, Protein Interaction Domains and Motifs, Oncology & Carcinogenesis, Aetiology, Cancer, Adaptor Proteins, Signal Transducing, Cell Proliferation, Regulation of gene expression, Neoplastic, Tumor, biology, Effector, Forkhead Box Protein M1, Signal Transducing, Adaptor Proteins, Signal transducing adaptor protein, Forkhead Transcription Factors, Pharmacology and Pharmaceutical Sciences, Gene Expression Regulation, Neoplastic, Gene Expression Regulation, Oncology, Hela Cells, Chaperone (protein), MCF-7 Cells, Cancer research, biology.protein, FOXM1, Apoptosis Regulatory Proteins, HT29 Cells, HeLa Cells

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3b22505bee1d46a3729d48f13aa063Test
https://doi.org/10.1158/1535-7163.mct-14-0650Test

4

Antibody-drug conjugate targeting CD46 eliminates multiple myeloma cells

المؤلفون: Peter Walter, Xiaobo Wu, Daniel W. Sherbenou, Bin Liu, Blake T. Aftab, Diego Acosta-Alvear, Thomas G. Martin, Aaron C Logan, Yang Su, Byron Hann, Marc A. Shuman, John P. Atkinson, Jeffrey L. Wolf, Arun P. Wiita, Christopher R. Behrens

المصدر: The Journal of clinical investigation, vol 126, iss 12

مصطلحات موضوعية: 0301 basic medicine, Immunoconjugates, Antibodies, Neoplasm, viruses, Cell, Gene Dosage, Medical and Health Sciences, Mice, Monoclonal, Multiple myeloma, Cancer, Tumor, biology, Antibodies, Monoclonal, General Medicine, Hematology, female genital diseases and pregnancy complications, 3. Good health, medicine.anatomical_structure, 5.1 Pharmaceuticals, Chromosomes, Human, Pair 1, Pair 1, Antibody, Development of treatments and therapeutic interventions, Multiple Myeloma, Human, Biotechnology, Research Article, Antibody-drug conjugate, medicine.drug_class, Immunology, Monoclonal antibody, Chromosomes, Antibodies, Cell Line, Membrane Cofactor Protein, 03 medical and health sciences, Rare Diseases, Clinical Research, Cell Line, Tumor, medicine, Genetics, Animals, Humans, Innate immune system, business.industry, medicine.disease, Xenograft Model Antitumor Assays, 030104 developmental biology, Cell culture, biology.protein, Cancer research, Neoplasm, Bone marrow, business

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4493ea8c812dbe33beb060ad3da7b1b3Test
https://europepmc.org/articles/PMC5127683Test/

5

Therapeutic potential of Hedgehog signaling inhibitors in cancer: rationale and clinical data

المؤلفون: Blake T. Aftab, Charles M. Rudin

المصدر: Clinical Investigation. 2:371-385

مصطلحات موضوعية: Cyclopamine, business.industry, Cancer, General Medicine, Pharmacology, medicine.disease, Hedgehog signaling pathway, chemistry.chemical_compound, chemistry, Cancer stem cell, Cancer cell, medicine, Cancer research, Basal cell carcinoma, Clinical efficacy, business, Hedgehog

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::ea11d09b91b0cd252e05cd9094324126Test
https://doi.org/10.4155/cli.12.20Test

6

Targeting the AAA ATPase p97 as an Approach to Treat Cancer through Disruption of Protein Homeostasis

المصدر: Cancer cell, vol 28, iss 5

مصطلحات موضوعية: Cancer Research, Indoles, Nude, Apoptosis, Mice, SCID, Mice, 0302 clinical medicine, Neoplasms, Homeostasis, 2.1 Biological and endogenous factors, Molecular Targeted Therapy, Nuclear protein, Enzyme Inhibitors, Aetiology, Cancer, Regulation of gene expression, Adenosine Triphosphatases, 0303 health sciences, Tumor, Molecular Structure, Blotting, Reverse Transcriptase Polymerase Chain Reaction, Nuclear Proteins, Endoplasmic Reticulum-Associated Degradation, Ubiquitinated Proteins, AAA proteins, 3. Good health, Cell biology, Gene Expression Regulation, Neoplastic, Oncology, 030220 oncology & carcinogenesis, RNA Interference, Western, Biotechnology, Blotting, Western, Oncology and Carcinogenesis, Mice, Nude, Biology, Endoplasmic-reticulum-associated protein degradation, SCID, Article, Cell Line, 03 medical and health sciences, Cell Line, Tumor, Genetics, ERAD pathway, Animals, Humans, Oncology & Carcinogenesis, 030304 developmental biology, Neoplastic, Endoplasmic reticulum, HEK 293 cells, Neurosciences, Cell Biology, HCT116 Cells, Xenograft Model Antitumor Assays, Pyrimidines, HEK293 Cells, Gene Expression Regulation, Unfolded protein response, CRISPR-Cas Systems, K562 Cells

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c0010f90064594c471ccfefe9d9d4dTest
https://escholarship.org/uc/item/1mg4031wTest

7

Itraconazole Inhibits Angiogenesis and Tumor Growth in Non–Small Cell Lung Cancer

المؤلفون: Charles M. Rudin, Jun O. Liu, Blake T. Aftab, Irina Dobromilskaya

المصدر: Cancer Research. 71:6764-6772

مصطلحات موضوعية: Cancer Research, Lung Neoplasms, Bevacizumab, Angiogenesis, Itraconazole, Antifungal drug, Angiogenesis Inhibitors, Antineoplastic Agents, Mice, SCID, Adenocarcinoma, Pharmacology, Biology, Article, Neovascularization, Mice, Cell Movement, Mice, Inbred NOD, Carcinoma, Non-Small-Cell Lung, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Humans, Lung cancer, Cells, Cultured, Aged, Tube formation, Dose-Response Relationship, Drug, Neovascularization, Pathologic, Endothelial Cells, Cancer, Hypoxia-Inducible Factor 1, alpha Subunit, medicine.disease, Xenograft Model Antitumor Assays, Oncology, Carcinoma, Squamous Cell, Intercellular Signaling Peptides and Proteins, Cisplatin, Drug Screening Assays, Antitumor, medicine.symptom, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57b030299e6434523fc10f0bbcf18a80Test
https://doi.org/10.1158/0008-5472.can-11-0691Test

8

Abstract PR07: Systematic genetic interaction maps reveal rewiring of the stress response network and resulting vulnerabilities in leukemia and multiple myeloma cells

المؤلفون: Min Cho, Blake T. Aftab, Jonathan S. Weissman, Peter Walter, Luke A. Gilbert, Yuwen Chen, Jason E. Gestwicki, Martin Kampmann, Xiaokai Li, Diego Acosta-Alvear

المصدر: Cancer Research. 73:PR07-PR07

مصطلحات موضوعية: Genetics, Cancer Research, Cancer, Biology, medicine.disease, Leukemia, Oncology, RNA interference, Cancer cell, medicine, Unfolded protein response, Gene, Functional genomics, K562 cells

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::530903a35049d3dcd37e6c7abe7e6ef3Test
https://doi.org/10.1158/1538-7445.fbcr13-pr07Test

9

Abstract 5469: SAR650984, an anti-CD38 antibody, shows anti-tumor activity in a preclinical model of multiple myeloma

المؤلفون: Jeffrey L. Wolf, Byron Hann, Thomas Martin, Donghui Wang, Ti Cai, Blake T. Aftab, Yun-Kit Hom

المصدر: Cancer Research. 73:5469-5469

مصطلحات موضوعية: Antibody-dependent cell-mediated cytotoxicity, Cancer Research, biology, business.industry, Cancer, Context (language use), CD38, medicine.disease, Oncology, medicine, Cancer research, biology.protein, Progression-free survival, Antibody, business, Cytotoxicity, Multiple myeloma

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::52eca2a55c01e31b2c8525ff8052707eTest
https://doi.org/10.1158/1538-7445.am2013-5469Test

10

Abstract 5644: Itraconazole and arsenic trioxide inhibit hedgehog pathway activation and tumor growth associated with acquired resistance to vismodegib

المؤلفون: Daniel H. Kim, Philip A. Beachy, Ervin H. Epstein, Jynho Kim, Blake T. Aftab, Charles M. Rudin, Emily M. King, James Kim, Jean Y. Tang

المصدر: Cancer Research. 73:5644-5644

مصطلحات موضوعية: Medulloblastoma, Cancer Research, business.industry, Itraconazole, Vismodegib, Cancer, Pharmacology, medicine.disease, Hedgehog signaling pathway, chemistry.chemical_compound, Oncology, chemistry, In vivo, medicine, Arsenic trioxide, Smoothened, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c9b346653233c458f5a056dcf2c77a4cTest
https://doi.org/10.1158/1538-7445.am2013-5644Test

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