المؤلفون: Glaviano, Antonino, Foo, Aaron, Lam, Hiu, Yap, Kenneth, Jacot, William, Jones, Robert, Eng, Huiyan, Nair, Madhumathy, Makvandi, Pooyan, Geoerger, Birgit, Kulke, Matthew, Baird, Richard, Prabhu, Jyothi, Carbone, Daniela, Pecoraro, Camilla, Teh, Daniel, Sethi, Gautam, Cavalieri, Vincenzo, Lin, Kevin, Javidi-Sharifi, Nathalie, Toska, Eneda, Davids, Matthew, Brown, Jennifer, Diana, Patrizia, Stebbing, Justin, Kumar, Alan, Fruman, David

المصدر: Molecular Cancer. 22(1)

مصطلحات موضوعية: AKT inhibitors, ATP-competitive mTOR inhibitors, Allosteric mTOR inhibitors, Bi-steric mTOR inhibitors, Cancer, Dual PI3K/mTOR inhibitors, Isoform-specific PI3K inhibitors, PDK1 inhibitors, PI3K/AKT/mTORC pathway, Pan PI3K inhibitors, Humans, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Signal Transduction, TOR Serine-Threonine Kinases, Neoplasms

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3x80g7hpTest

المؤلفون: Zhang, Ziyang, Fan, Qiwen, Luo, Xujun, Lou, Kevin, Weiss, William A, Shokat, Kevan M

المصدر: Nature. 609(7928)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Medicinal and Biomolecular Chemistry, Chemical Sciences, Biological Psychology, Psychology, Pharmacology and Pharmaceutical Sciences, Neurosciences, Orphan Drug, Cancer, Rare Diseases, Brain Disorders, Brain Cancer, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Neurological, Humans, Brain, Drug Therapy, Combination, Glioblastoma, Ligands, MTOR Inhibitors, Sirolimus, Tacrolimus Binding Protein 1A, TOR Serine-Threonine Kinases, Xenograft Model Antitumor Assays, General Science & Technology

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/30v9v9kdTest

المؤلفون: Eskander, Ramez N, Tewari, Krishnansu S

المصدر: Expert Review of Clinical Pharmacology. 7(6)

مصطلحات موضوعية: Reproductive Medicine, Biomedical and Clinical Sciences, Oncology and Carcinogenesis, Cervical Cancer, Uterine Cancer, Clinical Trials and Supportive Activities, Clinical Research, Cancer, Biotechnology, Rare Diseases, Animals, Antineoplastic Agents, Clinical Trials, Phase II as Topic, Drug Design, Female, Genital Neoplasms, Female, Humans, Neoplasm Recurrence, Local, Phosphoinositide-3 Kinase Inhibitors, Proto-Oncogene Proteins c-akt, TOR Serine-Threonine Kinases, cervical cancer, clear cell ovarian cancer, endometrial cancer, mTOR inhibitors, PI3K/AKT/mTOR pathway, PTEN, Pharmacology and Pharmaceutical Sciences, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/01p8v6nvTest

المؤلفون: Kevin Lou, Ziyang Zhang, Kevan M. Shokat, Xujun Luo, William A. Weiss, Qi-Wen Fan

المصدر: Nature, vol 609, iss 7928

مصطلحات موضوعية: Drug, General Science & Technology, media_common.quotation_subject, Central nervous system, Tacrolimus Binding Protein 1A, Pharmacology, Ligands, Rare Diseases, Drug Therapy, medicine, Humans, Adverse effect, PI3K/AKT/mTOR pathway, media_common, Cancer, Sirolimus, Multidisciplinary, Kinase, business.industry, TOR Serine-Threonine Kinases, Neurosciences, Brain, MTOR Inhibitors, Ligand (biochemistry), medicine.disease, Xenograft Model Antitumor Assays, Brain Disorders, Brain Cancer, medicine.anatomical_structure, FKBP, Orphan Drug, 5.1 Pharmaceuticals, Combination, Neurological, Drug Therapy, Combination, Development of treatments and therapeutic interventions, business, Glioblastoma

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d384cbe2d04023b9624254d84e3a1a69Test
https://doi.org/10.1038/s41586-022-05213-yTest

المؤلفون: Seyed Mohammad Abedi, Samaneh Vaseghi, Nasrin Abbasi Gharibkandi, Alireza Mardanshahi, Sajjad Molavipordanjani

المصدر: Molecular Biology Reports. 48:1-14

مصطلحات موضوعية: Cell Survival, medicine.medical_treatment, Apoptosis, Radiation Tolerance, Phosphatidylinositol 3-Kinases, Cell Line, Tumor, Neoplasms, Autophagy, Genetics, medicine, Humans, Radiosensitivity, Protein Kinase Inhibitors, Molecular Biology, Protein kinase B, PI3K/AKT/mTOR pathway, Cell Proliferation, Phosphoinositide-3 Kinase Inhibitors, Cell growth, Akt/PKB signaling pathway, business.industry, TOR Serine-Threonine Kinases, Cell Cycle, Cancer, MTOR Inhibitors, General Medicine, medicine.disease, Radiation therapy, Cancer research, business, Proto-Oncogene Proteins c-akt, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18fdb87979d16875fbb742eee534b74bTest
https://doi.org/10.1007/s11033-021-06607-3Test

المؤلفون: Chiara Borsari, Matthias P. Wymann, Martina De Pascale

المصدر: Chemmedchem

مصطلحات موضوعية: mTOR inhibitors, Structural similarity, Allosteric regulation, physicochemical properties, Blood–brain barrier, Biochemistry, binding modes, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, chemical scaffolds, Drug Discovery, medicine, BBB permeability, Humans, General Pharmacology, Toxicology and Pharmaceutics, Protein Kinase Inhibitors, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, 030304 developmental biology, Pharmacology, 0303 health sciences, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Kinase, TOR Serine-Threonine Kinases, Organic Chemistry, Cancer, Minireviews, medicine.disease, Chemical space, 3. Good health, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Cancer research, biology.protein, Molecular Medicine, Minireview

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::610b11369182775aec800164fa18275dTest
https://doi.org/10.1002/cmdc.202100332Test

المؤلفون: Sandra Deady, Yvonne Williams, Siona Ni Raghallaigh, Diarmuid D. Houlihan, Donal J. Sexton, Alexander Dudley, Aiden McCormick, Patrick G. Morris, Eamonn O'Leary, Susan L. Murray, Peter J. Conlon, James P. O'Neill, Fergus Daly, Patrick O'Kelly, Nicholas R. Rutledge, Fergal J. Moloney

المصدر: Renal Failure, Vol 42, Iss 1, Pp 607-612 (2020)
Renal Failure
article-version (VoR) Version of Record

مصطلحات موضوعية: Male, Oncology, Skin Neoplasms, medicine.medical_treatment, 030232 urology & nephrology, 030204 cardiovascular system & hematology, lcsh:RC870-923, Critical Care and Intensive Care Medicine, Postoperative Complications, 0302 clinical medicine, Child, Aged, 80 and over, Kidney, immunosuppression, skin cancer, Drug Substitution, Incidence, TOR Serine-Threonine Kinases, Incidence (epidemiology), Immunosuppression, General Medicine, Middle Aged, Discovery and development of mTOR inhibitors, surgical procedures, operative, medicine.anatomical_structure, Nephrology, mtor inhibitor, Female, Immunosuppressive Agents, Research Article, Adult, medicine.medical_specialty, Adolescent, Calcineurin Inhibitors, Renal function, Young Adult, 03 medical and health sciences, Internal medicine, renal transplant, medicine, Humans, cancer, Aged, Retrospective Studies, Sirolimus, business.industry, Cancer, lcsh:Diseases of the genitourinary system. Urology, medicine.disease, Kidney Transplantation, Liver Transplantation, liver transplant, Clinical Study, Skin cancer, business, Ireland, Non melanoma

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c4e1d163b64173d7c43c61a203615f2Test
https://doi.org/10.1080/0886022x.2020.1785499Test

المؤلفون: Olivier Tredan, Cecile Vicier, Thibault Dayris, Olivia Fromigué, Ibrahim Bouakka, Bojana Stefanovska, Véronique Scott, Anna Rocca, Olivia Le Saux, Fabrice Andre, Suzette Delaloge, Thomas Bachelot, Vasily Ogryzko

المساهمون: Prédicteurs moléculaires et nouvelles cibles en oncologie (PMNCO), Institut Gustave Roussy (IGR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Institut Gustave Roussy (IGR), Aspects métaboliques et systémiques de l'oncogénèse pour de nouvelles approches thérapeutiques (METSY), Institut Gustave Roussy (IGR)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Département de médecine oncologique [Gustave Roussy], Centre National de la Recherche Scientifique (CNRS), Département d'Oncologie Médicale [Lyon] ( Centre Léon Bérard), Centre Léon Bérard [Lyon], FROMIGUE, OLIVIA

المصدر: Cancer Research
Cancer Research, American Association for Cancer Research, 2020, 80 (11), pp.2190-2203. ⟨10.1158/0008-5472.CAN-19-2366⟩
Cancer Research, 2020, 80 (11), pp.2190-2203. ⟨10.1158/0008-5472.CAN-19-2366⟩

مصطلحات موضوعية: Cancer Research, Spliceosome, mTOR inhibitors, RNA splicing, Gustave Roussy (taxe d'apprentissage), Down-Regulation, Gene Expression, Antineoplastic Agents, Cell Cycle Proteins, [SDV.CAN]Life Sciences [q-bio]/Cancer, Protein Serine-Threonine Kinases, Biology, 03 medical and health sciences, 0302 clinical medicine, Opération Parrains Chercheurs, Downregulation and upregulation, [SDV.CAN] Life Sciences [q-bio]/Cancer, Cell Line, Tumor, Neoplasms, Odyssea, Dassault Foundation, medicine, Humans, Everolimus, Breast, Promoter Regions, Genetic, Psychological repression, PI3K/AKT/mTOR pathway, 030304 developmental biology, mammalian target of rapamycin, Sirolimus, 0303 health sciences, Kinase, TOR Serine-Threonine Kinases, FKBP Financial support: This work was supported by INSERM, RNA-Binding Proteins, Cancer, medicine.disease, 3. Good health, Repressor Proteins, Oncology, TRIB3, 030220 oncology & carcinogenesis, MCF-7 Cells, Cancer research, Rapalogs regulate pre-mRNA splicing TRB3

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf0c777d140ecb278ed542caff1cb62fTest
https://www.hal.inserm.fr/inserm-02768801/file/2190.full.pdfTest

المؤلفون: Ana María Hurtado, Satu Mustjoki, Urpu Salmenniemi, Jani Huuhtanen, Pekka Ellonen, Rajiv K. Khajuria, Mikko Myllymäki, Matti Kankainen, Daehong Kim, Sofie Lundgren, Mikko A. I. Keränen, Giljun Park, Maija Itälä-Remes, Tzu Hua Chen-Liang, Andres Jerez, Samuli Eldfors, Laura Cardeñoso, Sari Hannula, Oscar Brück, Anna Kreutzman, Valle Gómez García de Soria, Tapio Lönnberg, Cecilia Muñoz-Calleja

المساهمون: Department of Clinical Chemistry and Hematology, Hematologian yksikkö, HUS Comprehensive Cancer Center, Department of Oncology, TRIMM - Translational Immunology Research Program, HUSLAB, University of Helsinki, Research Programs Unit, Institute for Molecular Medicine Finland, Department of Medical and Clinical Genetics, Helsinki University Hospital Area, Digital Precision Cancer Medicine (iCAN), Division of Pharmaceutical Biosciences, UAM. Departamento de Medicina, Instituto de Investigación Sanitaria Hospital Universitario de La Princesa (IIS-IP)

المصدر: Biblos-e Archivo: Repositorio Institucional de la UAM
Universidad Autónoma de Madrid
Nature Communications, Vol 11, Iss 1, Pp 1-17 (2020)
Nature Communications
Biblos-e Archivo. Repositorio Institucional de la UAM
instname

مصطلحات موضوعية: 0301 basic medicine, Resistance to mTOR inhibitors, Somatic cell, T-Lymphocytes, medicine.medical_treatment, NF-KAPPA-B, Graft vs Host Disease, General Physics and Astronomy, Apoptosis, Hematopoietic stem cell transplantation, medicine.disease_cause, Graft-versus-host disease, mTORC2, ACTIVATION, Pathogenesis, 0302 clinical medicine, immune system diseases, hemic and lymphatic diseases, lcsh:Science, Immunity, Cellular, Mutation, Multidisciplinary, TOR Serine-Threonine Kinases, CANCER, Cellular immunity, 3. Good health, surgical procedures, operative, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Haematological diseases, Mutations, Protein Binding, EXPRESSION, Medicina, Science, T cell, Blotting, Western, 3122 Cancers, T cells, BIOLOGY, Article, General Biochemistry, Genetics and Molecular Biology, REPERTOIRE, 03 medical and health sciences, medicine, Humans, Immunoprecipitation, STAT3 MUTATIONS, PI3K/AKT/mTOR pathway, Cell Proliferation, business.industry, STEM-CELL TRANSPLANTATION, General Chemistry, medicine.disease, HEK293 Cells, 030104 developmental biology, DISCOVERY, Alteration and activation, Cancer research, Hematopoietic stem cell transplantation (HSCT), lcsh:Q, business, CD4(+)

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80004dc6bc4cf39c734b43d69bf77021Test
https://doi.org/10.1038/s41467-020-16115-wTest

المؤلفون: Glaviano, A, Foo, ASC, Lam, HY, Yap, KCH, Jacot, W, Jones, RH, Eng, H, Nair, MG, Makvandi, P, Geoerger, B, Kulke, MH, Baird, RD, Prabhu, JS, Carbone, D, Pecoraro, C, Teh, DBL, Sethi, G, Cavalieri, V, Lin, KH, Javidi-Sharifi, NR, Toska, E, Davids, MS, Brown, JR, Diana, P, Stebbing, J, Fruman, DA, Kumar, AP

المساهمون: CANCER SCIENCE INSTITUTE OF SINGAPORE, MICROBIOLOGY AND IMMUNOLOGY, PHARMACOLOGY, PHYSIOLOGY

المصدر: Elements

مصطلحات موضوعية: AKT inhibitors, ATP-competitive mTOR inhibitors, Allosteric mTOR inhibitors, Bi-steric mTOR inhibitors, Cancer, Dual PI3K/mTOR inhibitors, Isoform-specific PI3K inhibitors, PDK1 inhibitors, PI3K/AKT/mTORC pathway, Pan PI3K inhibitors, Humans, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, Signal Transduction, TOR Serine-Threonine Kinases, Neoplasms

العلاقة: Glaviano, A, Foo, ASC, Lam, HY, Yap, KCH, Jacot, W, Jones, RH, Eng, H, Nair, MG, Makvandi, P, Geoerger, B, Kulke, MH, Baird, RD, Prabhu, JS, Carbone, D, Pecoraro, C, Teh, DBL, Sethi, G, Cavalieri, V, Lin, KH, Javidi-Sharifi, NR, Toska, E, Davids, MS, Brown, JR, Diana, P, Stebbing, J, Fruman, DA, Kumar, AP (2023-12-01). PI3K/AKT/mTOR signaling transduction pathway and targeted therapies in cancer. Molecular Cancer 22 (1) : 138-. ScholarBank@NUS Repository. https://doi.org/10.1186/s12943-023-01827-6Test; https://scholarbank.nus.edu.sg/handle/10635/245930Test

الإتاحة: https://doi.org/10.1186/s12943-023-01827-6Test
https://scholarbank.nus.edu.sg/handle/10635/245930Test