Quality of life for older patients with cancer: a review of the evidence supporting melatonin use
| العنوان: | Quality of life for older patients with cancer: a review of the evidence supporting melatonin use |
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| المؤلفون: | Judith Passildas, Catherine Abrial, Angeline Ginzac, Xavier Durando, Marie-Ange Mouret-Reynier, Julian Biau, Marie-Odile Hager, Sophie Dubois, Fabrice Kwiatkowski, Emilie Thivat |
| المساهمون: | Imagerie Moléculaire et Stratégies Théranostiques (IMoST), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Centre d'investigation Clinique, UMR501, 63011 CLERMONT-FERRAND (CIC), Division de Recherche Clinique, Délégation Recherche Clinique et Innovation, Centre de Lutte contre le Cancer, Centre Jean PERRIN, 58 rue Montalembert, 63011 Clermont-Ferrand Cedex1, Département d'oncologie médicale, Centre Jean PERRIN, 63011 Clermont-Ferrand, Géronto-pôle [CHU Clermont-Ferrand], CHU Louise Michel [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, Département de Radiothérapie [Centre Jean Perrin, Clermont-Ferrand], Centre Jean Perrin [Clermont-Ferrand] (UNICANCER/CJP), UNICANCER-UNICANCER, Université Clermont Auvergne, INSERM, U1240 Imagerie Moléculaire et Stratégie Théranostiques, Centre Jean PERRIN, 63011 Clermont-Ferrand, GINZAC, Angeline |
| المصدر: | Aging Clinical and Experimental Research Aging Clinical and Experimental Research, Springer Verlag, 2020, ⟨10.1007/s40520-020-01532-0⟩ |
| بيانات النشر: | HAL CCSD, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Quality of life, Oncology, Aging, medicine.medical_specialty, medicine.medical_treatment, Population, [SDV.CAN]Life Sciences [q-bio]/Cancer, Review, Older population, Melatonin, 03 medical and health sciences, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, Older patients, Neoplasms, Internal medicine, medicine, Chemotherapy, Humans, 030212 general & internal medicine, education, ComputingMilieux_MISCELLANEOUS, Cancer, Aged, education.field_of_study, [SDV.MHEP.GEG] Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, business.industry, [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, medicine.disease, 3. Good health, Clinical trial, [SDV.AEN] Life Sciences [q-bio]/Food and Nutrition, 030220 oncology & carcinogenesis, Geriatrics and Gerontology, Sleep, business, [SDV.AEN]Life Sciences [q-bio]/Food and Nutrition, medicine.drug |
| الوصف: | Purpose The proportion of older populations living with cancer is on the increase. Maintaining or improving their quality of life (QoL) has become an important goal in the treatment of cancer and has become an endpoint in clinical trials. Melatonin regulates a wide variety of physiological functions and is involved in the initiation of sleep and the improvement of QoL. With age, the secretion of melatonin decreases and could lead to a deterioration in QoL. Methods Literature searches were conducted using the PubMed database. The search terms and derivatives of “metastatic cancer”, “older patients”, “quality of life” and “melatonin” were used. Titles and abstracts were screened to identify whether studies were relevant for full-text screening. Results There is major concern about the symptoms older cancer patients encounter during treatment because they can impact their QoL. Melatonin supplementation presents several benefits for older patients: improvement in survival, decrease in symptoms induced by cancer and cancer treatment, and also improvements in quality of life. Conclusion It therefore seems appropriate to study the impact of melatonin supplementation during cytotoxic therapy on QoL among elderly patients with metastatic cancer. The use of melatonin as a therapeutic strategy seems particularly suitable for elderly patients, a population known to secrete significantly less melatonin. However, to date, no studies have been conducted in this population. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1594-0667 1720-8319 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cf96e1f28056c224acc5a5b02547848Test https://hal.archives-ouvertes.fr/hal-02525883Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....7cf96e1f28056c224acc5a5b02547848 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15940667 17208319 |
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