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Tumor Vessel Normalization by Chloroquine Independent of Autophagy

التفاصيل البيبلوغرافية
العنوان: Tumor Vessel Normalization by Chloroquine Independent of Autophagy
المؤلفون: Jasper Wouters, Holger Gerhardt, Hugo Vankelecom, Marjan Garmyn, Peter Carmeliet, Annelies Quaegebeur, Hannelore Maes, Sandra Schoors, Anne-Clémence Vion, Mieke Dewerchin, Stijn Moens, Katrien De Bock, Stefan Vinckier, Bart Ghesquière, Anna Kuchnio, Maria Georgiadou, Wim Annaert, Kris Nys, Chantal M. Boulanger, Patrizia Agostinis, Aleksandar Peric, Freddy Radtke, Elisabetta Dejana
المساهمون: Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), VIB Center for the Biology of Disease [Louvain, Belgique] (VIB-CBD), Vlaams Instituut voor Biotechnologie [Ghent, Belgique] (VIB), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Ecole Polytechnique Fédérale de Lausanne (EPFL), The institute of cancer research [London], FIRC Institute of Molecular Oncology Foundation, IFOM, Istituto FIRC di Oncologia Molecolare (IFOM), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Vion, Anne-clemence
المصدر: Cancer Cell
Cancer Cell, Elsevier, 2014, 26 (2), pp.190-206. ⟨10.1016/j.ccr.2014.06.025⟩
بيانات النشر: Elsevier Inc.
مصطلحات موضوعية: Cancer Research, Skin Neoplasms, Endothelium, medicine.medical_treatment, Melanoma, Experimental, Mice, Nude, Angiogenesis Inhibitors, [SDV.CAN]Life Sciences [q-bio]/Cancer, Autophagy-Related Protein 5, Metastasis, Neovascularization, Mice, [SDV.CAN] Life Sciences [q-bio]/Cancer, Chloroquine, Cell Line, Tumor, Autophagy, medicine, Animals, Humans, Neoplasm Invasiveness, Receptor, Notch1, Cell Proliferation, Chemotherapy, Neovascularization, Pathologic, business.industry, Melanoma, Endothelial Cells, Drug Synergism, Cell Biology, medicine.disease, Xenograft Model Antitumor Assays, Tumor Burden, 3. Good health, Mice, Inbred C57BL, medicine.anatomical_structure, Oncology, Cancer cell, Immunology, Cancer research, Camptothecin, Endothelium, Vascular, medicine.symptom, business, Microtubule-Associated Proteins, medicine.drug
الوصف: Chloroquine (CQ) has been evaluated as an autophagy blocker for cancer treatment, but it is unknown if it acts solely by inhibiting cancer cell autophagy. We report that CQ reduced tumor growth but improved the tumor milieu. By normalizing tumor vessel structure and function and increasing perfusion, CQ reduced hypoxia, cancer cell invasion, and metastasis, while improving chemotherapy delivery and response. Inhibiting autophagy in cancer cells or endothelial cells (ECs) failed to induce such effects. CQ's vessel normalization activity relied mainly on alterations of endosomal Notch1 trafficking and signaling in ECs and was abrogated by Notch1 deletion in ECs in vivo. Thus, autophagy-independent vessel normalization by CQ restrains tumor invasion and metastasis while improving chemotherapy, supporting the use of CQ for anticancer treatment. publisher: Elsevier articletitle: Tumor Vessel Normalization by Chloroquine Independent of Autophagy journaltitle: Cancer Cell articlelink: http://dx.doi.org/10.1016/j.ccr.2014.06.025Test content_type: article copyright: Copyright © 2014 Elsevier Inc. All rights reserved. ispartof: CANCER CELL vol:26 issue:2 pages:190-206 ispartof: location:United States status: published
وصف الملف: application/pdf; Print
اللغة: English
تدمد: 1535-6108
DOI: 10.1016/j.ccr.2014.06.025
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c36d76c7c023f6efab0b5762c069ce93Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....c36d76c7c023f6efab0b5762c069ce93
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15356108
DOI:10.1016/j.ccr.2014.06.025