التفاصيل البيبلوغرافية
| العنوان: |
Six and 12 Weeks of Caloric Restriction Increases β Cell Function and Lowers Fasting and Postprandial Glucose Concentrations in People with Type 2 Diabetes. |
| المؤلفون: |
Sathananthan, Matheni, Shah, Meera, Edens, Kim L., Grothe, Karen B., Piccinini, Francesca, Farrugia, Luca P., Micheletto, Francesco, Dalla Man, Chiara, Cobelli, Claudio, Rizza, Robert A., Camilleri, Michael, Vella, Adrian |
| المصدر: |
Journal of Nutrition; 9/1/2015, Vol. 145 Issue 9, p2046-2051, 6p |
| مصطلحات موضوعية: |
INSULIN research, GLUCOSE, BODY mass index, CALORIC content of foods, TYPE 2 diabetes -- Nutritional aspects |
| مستخلص: |
Background: Caloric restriction alone has been shown to improve insulin action and fasting glucose metabolism; however, the mechanism by which this occurs remains uncertain. Objective: We sought to quantify the effect of caloric restriction on b cell function and glucose metabolism in people with type 2 diabetes. Methods: Nine subjects (2 men, 7 women) with type 2 diabetes [BMI (in kg/m²): 40.6 ± 1.4; age: 58 ± 3 y; glycated hemoglobin: 6.9% ± 0.2%] were studied using a triple-tracer mixed meal after withdrawal of oral diabetes therapy. The oral minimal model was used to measure b cell function. Caloric restriction limited subjects to a pureed diet (<900 kcal/d) for the 12 wk of study. The studies were repeated after 6 and 12 wk of caloric restriction. Results: Fasting glucose concentrations decreased significantly from baseline after 6 wk of caloric restriction with no further reduction after a further 6 wk of caloric restriction (9.8 ± 1.3, 5.9 ± 0.2, and 6.2 ± 0.3 µmol/L at baseline and after 6 and 12 wk of caloric restriction, respectively; P = 0.01) because of decreased fasting endogenous glucose production (EGP: 20.4 ± 1.1, 16.2 ± 0.8, and 17.4 ± 1.1 µmol ⋅ kg-1 ⋅ min-1 at baseline and after 6 and 12 wk of caloric restriction, respectively; P = 0.03). These changes were accompanied by an improvement in b cell function measured by the disposition index (189 ± 51, 436 ± 68, and 449 ± 67 10-14 dL ⋅ kg-1 ⋅ min-2 ⋅ pmol-1 at baseline and after 6 and 12 wk of caloric restriction, respectively; P = 0.01). Conclusions: Six weeks of caloric restriction lowers fasting glucose and EGP with accompanying improvements in b cell function in people with type 2 diabetes. An additional 6 wk of caloric restriction maintained the improvement in glucose metabolism. This trial was registered at clinicaltrials.gov as NCT01094054. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
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