التفاصيل البيبلوغرافية
| العنوان: |
CASY-1, an ortholog of calsyntenins/alcadeins, is essential for learning in Caenorhabditis elegans. |
| المؤلفون: |
Ikeda, Daisuke D.1,2, Duan, Yukan3, Matsuki, Masahiro1,2,4 iino@biochem.s.u-tokyo.ac.jp, Kunitomo, Hirofumi1, Hutter, Harald5, Hedgecock, Edward M.3, Iino, Yuichi1,2 iino@biochem.s.u-tokyo.ac.jp |
| المصدر: |
Proceedings of the National Academy of Sciences of the United States of America. 4/1/2008, Vol. 105 Issue 13, p5260-5265. 6p. 1 Chart, 1 Graph. |
| مصطلحات موضوعية: |
*CADHERINS, *CAENORHABDITIS elegans genetics, *CELL adhesion molecules, *PROTEIN-protein interactions, *CHEMOTAXIS |
| مستخلص: |
Calsyntenins/alcadeins are type I transmembrane proteins with two extracellular cadherin domains highly expressed in mammalian brain. They form a tripartite complex with X11/X11L and APP (amyloid precursor protein) and are proteolytically processed in a similar fashion to APP. Although a genetic association of calsyntenin-2 with human memory performance has recently been reported, physiological roles and molecular functions of the protein in the nervous system are poorly understood. Here, we show that CASY-1, the Caenorhabditis elegans ortholog of calsyntenins/alcadeins, is essential for multiple types of learning. Through a genetic screen, we found that casy-1 mutants show defects in salt chemotaxis learning. casy-1 mutants also show defects in temperature learning, olfactory adaptation, and integration of two sensory signals. casy-1 is widely expressed in the nervous system. Expression of casy-1 in a single sensory neuron and at the post-developmental stage is sufficient for its function in salt chemotaxis learning. The fluorescent protein-tagged ectodomain of CASY-1 is released from neurons. Moreover, functional domain analyses revealed that both cytoplasmic and transmembrane domains of this protein are dispensable, whereas the ectodomain, which contains the LG/LNS-like domain, is critically required for learning. These results suggest that learning is modulated by the released ectodomain of CASY-1. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
Full Text Finder