التفاصيل البيبلوغرافية
| العنوان: |
The serotonin system in the hippocampus CA3 involves in effects of CSDS on social recognition in adult female mandarin voles (Microtus mandarinus). |
| المؤلفون: |
Wang, Limin1 (AUTHOR), He, Zhixiong1 (AUTHOR), Zhu, Zhenxiang1 (AUTHOR), Yuan, Wei1 (AUTHOR), Cai, Wenqi1 (AUTHOR), Li, Laifu1 (AUTHOR), Zhang, Jing1 (AUTHOR), Hou, Wenjuan1 (AUTHOR), Yang, Yang1 (AUTHOR), Zhang, Xueni1 (AUTHOR), Guo, Qianqian1 (AUTHOR), Wang, Xia1 (AUTHOR), Lian, Zhenmin1 (AUTHOR), Tai, Fadao1 (AUTHOR) taifadao@snnu.edu.cn |
| المصدر: |
Progress in Neuro-Psychopharmacology & Biological Psychiatry. Dec2019, Vol. 95, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*MICROTUS, *VOLES, *SEROTONIN receptors, *MENTAL illness |
| مستخلص: |
Chronic social defeat stress (CSDS) exacerbated the development of stress-related psychiatric disorders, and the social recognition dysfunction is the core feature of many psychiatric disorders. However, the effects of CSDS on female social recognition and the underlying neural mechanisms remain unclear. Using highly aggressive adult female mandarin voles (Microtus mandarinus) as animal model, the aim of this work is to investigate the effects of CSDS on social recognition in adult female rodents and the neurobiological mechanisms underlying these effects. Our results indicate the CSDS disrupted the normal social recognition in adult female voles. Meanwhile, defeated voles exhibited increased neural activity in the DG, CA1 and CA3 of the hippocampus. Furthermore, CSDS reduced levels of serotonin (5-HT) and serotonin 1A receptors (5-HT 1A R) in the CA3. We also discovered that microinjection of 8-OH-DPAT into the CA3 effectively reversed the social recognition deficits induced by CSDS, and an infusion of WAY-100635 into the CA3 of control female voles impaired social recognition. Moreover, targeted activation of the 5-HT neuron projection from the DRN to CA3 by long-term administration of CNO significantly prevented the CSDS induced social recognition deficits. Taken together, our study demonstrated that CSDS induced social recognition deficits in adult female voles, and these effects were mediated by the action of 5-HT on the 5-HT 1A R in the hippocampus CA3. The projection from the DRN to CA3 may be involved in social recognition deficits induced by CSDS. • Chronic social defeat stress (CSDS) impaired social recognition in adult female voles. • CSDS reduced levels of 5-HT and 5-HT 1A R in the hippocampus CA3. • The deficit in social recognition can be reversed by 5-HT 1A R agonist. • Social recognition was impaired by 5-HT 1A R antagonist. • Targeted activation of 5-HT neuron projection from DRN to CA3 prevented the CSDS-induced deficit in social recognition. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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