دورية أكاديمية
Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients
| العنوان: | Procalcitonin and C-reactive protein to rule out early bacterial coinfection in COVID-19 critically ill patients |
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| المؤلفون: | Galli, Flavia, Bindo, Francesco, Motos, Anna, Fernández Barat, Laia, Barbeta, Enric, Gabarrús, Albert, Ceccato, Adrián, Bermejo Martín, Jesús Francisco, Ferrer, Ricard, Riera, Jordi, Peñuelas, Oscar, Lorente, José Ángel, De Gonzalo Calvo, David, Menéndez, Rosario, González, Jessica, Misuraca, Sofia, Palomeque, Andrea, Amaya Villar, Rosario, Añón Elizalde, José Manuel, Balan Mariño, Ana, Barberà, Carme, Barberán, José, Blandino Ortiz, Aaron, Bustamante Munguira, Elena, Caballero, Jesús, Cantón Bulnes, María Luisa, Carbajales Pérez, Cristina, Carbonell, Nieves, Catalán González, Mercedes, De Frutos, Raul, Franco, Nieves, Galbán, Cristóbal, López Lago, Ana, Gumucio Sanguino, Víctor D., De La Torre, María Del Carmen, Díaz, Emilio, Estella, Ángel, Gallego Curto, Elena, García Garmendia, José Luis, Gómez Pérez, José Manuel, Huerta, Arturo, Jorge García, Ruth Noemí, Loza Vázquez, Ana, Marin Corral, Judith, Martín Delgado, María Cruz, Martínez De La Gándara, Amalia, Martínez Varela, Ignacio, López Messa, Juan, Albaiceta, Guillermo M., Nieto, María Teresa, Novo, Mariana Andrea, Peñasco, Yhivian, Pérez García, Felipe, Pozo Laderas, Juan Carlos, Ricart, Pilar, Sagredo, Victor, Sánchez Miralles, Angel, Sancho Chinesta, Susana, Roche Campo, Ferran, Socias, Lorenzo, Solé Violan, Jordi, Suarez Sipmann, Fernando, Tamayo Lomas, Luis, Trenado, José, Úbeda, Alejandro, Valdivia, Luis Jorge, Vidal, Pablo, Boado, Maria Victoria, Rodriguez, Alejandro, Antonelli, Massimo, Blasi, Francesco, Barbé, Ferrán, Torres, Antoni |
| المساهمون: | Universidad de Alcalá. Departamento de Biomedicina y Biotecnología. Unidad docente de Microbiología y Parasitología |
| سنة النشر: | 2023 |
| المجموعة: | e_Buah - Biblioteca Digital de la Universidad de Alcalá |
| مصطلحات موضوعية: | Bacterial coinfection, C-reactive protein, COVID-19, Critically ill, Intensive care, Procalcitonin, Biología y Biomedicina/Biología, Biology |
| الوصف: | 12 p. ; Purpose: Although the prevalence of community-acquired respiratory bacterial coinfection upon hospital admission in patients with coronavirus disease 2019 (COVID-19) has been reported to be < 5%, almost three-quarters of patients received antibiotics. We aim to investigate whether procalcitonin (PCT) or C-reactive protein (CRP) upon admission could be helpful biomarkers to identify bacterial coinfection among patients with COVID-19 pneumonia. Methods: We carried out a multicentre, observational cohort study including consecutive COVID-19 patients admitted to 55 Spanish intensive care units (ICUs). The primary outcome was to explore whether PCT or CRP serum levels upon hospital admission could predict bacterial coinfection among patients with COVID-19 pneumonia. The secondary outcome was the evaluation of their association with mortality. We also conducted subgroups analyses in higher risk profile populations. Results: Between 5 February 2020 and 21 December 2021, 4076 patients were included, 133 (3%) of whom presented bacterial coinfection. PCT and CRP had low area under curve (AUC) scores at the receiver operating characteristic (ROC) curve analysis [0.57 (95% confidence interval (CI) 0.51-0.61) and 0.6 (95% CI, 0.55-0.64), respectively], but high negative predictive values (NPV) [97.5% (95% CI 96.5-98.5) and 98.2% (95% CI 97.5-98.9) for PCT and CRP, respectively]. CRP alone was associated with bacterial coinfection (OR 2, 95% CI 1.25-3.19; p = 0.004). The overall 15, 30 and 90 days mortality had a higher trend in the bacterial coinfection group, but without significant difference. PCT ? 0.12 ng/mL was associated with higher 90 days mortality. Conclusion: Our study suggests that measurements of PCT and CRP, alone and at a single time point, are not useful for ruling in or out bacterial coinfection in viral pneumonia by COVID-19. ; Instituto de Salud Carlos III ; FEDER ; Fondo Social Europeo ; CIBERES ; UNESPA |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 0342-4642 |
| العلاقة: | info:eu-repo/grantAgreement/ISCIII//COV20%00110/ES//; info:eu-repo/grantAgreement/ISCIII/Miguel Servet/CP20%00041/ES//; info:eu-repo/grantAgreement/ISCIII/Sara Borrell/ CD21%00087/ES//; Intensive Care Medicine, 2023, v. 49, n. 8, p. 934-945; http://hdl.handle.net/10017/60932Test; AR/0000047113; Intensive Care Medicine; 49; 945; 934 |
| DOI: | 10.1007/s00134-023-07161-1 |
| الإتاحة: | https://doi.org/10.1007/s00134-023-07161-1Test http://hdl.handle.net/10017/60932Test |
| حقوق: | © 2023 The Author(s) ; Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) ; http://creativecommons.org/licenses/by-nc-nd/4.0Test/ ; info:eu-repo/semantics/embargoedAccess |
| رقم الانضمام: | edsbas.855023FA |
| قاعدة البيانات: | BASE |
| تدمد: | 03424642 |
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| DOI: | 10.1007/s00134-023-07161-1 |