التفاصيل البيبلوغرافية
| العنوان: |
Red blood cell counts and indices in the elderly German population. |
| المؤلفون: |
Röhrig, Gabriele, Becker, Ingrid, Gutensohn, Kai, Nebe, Thomas |
| المصدر: |
Journal of Laboratory Medicine; Aug2018, Vol. 42 Issue 4, p131-139, 9p |
| مصطلحات موضوعية: |
ERYTHROCYTES, ANEMIA, BLOOD testing, BLOOD proteins, C-reactive protein, GLOBULINS, GLOMERULAR filtration rate, HEMATOCRIT, HEMATOLOGY, HEMOGLOBINS, LACTATE dehydrogenase, RETICULOCYTES, TRANSFERRIN, CROSS-sectional method, RETROSPECTIVE studies |
| مصطلحات جغرافية: |
GERMANY |
| الشركة/الكيان: |
WORLD Health Organization |
| مستخلص: |
Background: Data on peripheral blood cell values in older subjects are rare. While hemoglobin (Hb) values are supposed to change with rising age, little is known about reference values for other erythrocytic blood cell counts. This cross-sectional study was initiated to analyze hematologic laboratory parameters among subjects aged ≥60 years. Methods: This was a retrospective cross-sectional study of outpatient laboratory data between January 1st and December 31st, 2015 originating from a German countrywide laboratory group; inclusion criteria: age ≥60 years, normal C-reactive protein (CRP), transferrin saturation, reticulocytes, lactate dehydrogenase, haptoglobin and soluble transferrin receptor; exclusion criteria: glomerular filtration rate (GFR)<60 mL/min, lack of inclusion criteria; primary objective: assessment of the mean Hb value; secondary objective: assessment of mean values of red blood cell (RBC) counts. Results: Of 30,611 subjects ≥60 years, 4641 met the inclusion criteria and were thus considered hematologically healthy; the following age groups were formed: 60–69 years (2094), 70–79 years (2171), 80–89 years (360), >90 years (16); median values for male/female subjects were: Hb 15.2/14.0 g/dL, RBC 5.0/4.6/μL, mean cellular volume (MCV) 89/89/fl, mean corpuscular hemoglobin (MCH) 31/30 pg/RBC, mean corpuscular hemoglobin concentration (MCHC) 34/34 g/dL, hematocrit (hct) 44/41%. Statistical evaluation revealed a slight but significant decrease in values over age decades for all parameters except for MCH. However, all values remained within the recommended German Society of Hematology and Oncology (DGHO) reference ranges. Hb values remained above the recommended World Health Organization (WHO) cut-offs for definition of anemia. Conclusions: The results confirm the WHO reference values and are in accordance with the recommended DGHO reference values and previous results of other study cohorts outside Germany. There seems to be no need for establishing age-specific RBC or erythrocytic reference ranges for subjects >60 years. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Laboratory Medicine is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder