المؤلفون: Lin Qiao-min, Fu Xiong, Huang Yanwen, Wang Ru-chuan, Zhang Lin, Xuan Jie

المصدر: Chinese Journal of Electronics. 30:92-101

مصطلحات موضوعية: business.industry, Computer science, Applied Mathematics, Big data, Volume (computing), Initialization, Particle swarm optimization, 020206 networking & telecommunications, 02 engineering and technology, Machine learning, computer.software_genre, Global optimal, Intelligent algorithms, Recurrent neural network, 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, Artificial intelligence, Electrical and Electronic Engineering, business, computer

الوصف: Due to the challenge of increasing data volume, the traditional trust model is unable to manage data with high efficiency and effectively extract useful information hidden in big data. To fully utilize big data and combine machine learning with trust evaluation, a trust evaluation model based on Long short-term memory (LSTM) is presented. The powerful learning ability, expressive ability and dynamic timing of LSTM can be applied to study data while avoiding the vanishing and exploding gradient phenomena of traditional Recurrent neural networks (RNNs) to ensure that the model can learn sequences of random length and provide accurate trust evaluation. Targeting the performance instability caused by the LSTM model's random initialization of weights and thresholds, Particle swarm optimization (PSO), one of the intelligent algorithms, is introduced to find global optimal initial weights and thresholds. Experiments proved that the trust model proposed in this paper has high accuracy and contributes a new idea for trust evaluation in big data environments.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fb370dc9297243794fd8ca8b4b2bd82fTest
https://doi.org/10.1049/cje.2020.12.005Test

المؤلفون: Chao-zhen-yi Han, Na Li, Rui Wang, Kai Li, Jing Wang, Qiao-min Ru, Yuan Wang, Xin Liu, Mengtao Ma

المصدر: International Journal of Peptide Research and Therapeutics. 28

مصطلحات موضوعية: business.industry, Bioengineering, Pharmacology, Nerve injury, Biochemistry, Analytical Chemistry, Peripheral, Drug Discovery, Hyperalgesia, Morphine, medicine, Molecular Medicine, medicine.symptom, Opioid peptide, business, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::d19ed78bb3d8e0402ee86cf8b3d08fcaTest
https://doi.org/10.1007/s10989-021-10319-4Test

المؤلفون: Yongpo Jiang, Dan Zheng, Lin-Zhu Qian, Xiaoqiong Chu, Yang Weiying, Sheng Zhang, Chun-Guo Wang, Ronghai Lin, Zhang Wenyuan, Tao-Hsin Tung, Qiao-Min Zhang

المصدر: Frontiers in Cardiovascular Medicine, Vol 8 (2021)

مصطلحات موضوعية: lactate, medicine.medical_specialty, business.industry, venous-to-arterial carbon dioxide difference, Organ dysfunction, organ dysfunction, Odds ratio, Intensive care unit, base excess, law.invention, Cardiac surgery, law, RC666-701, Internal medicine, Statistical significance, medicine, Cardiopulmonary bypass, Cardiology, Diseases of the circulatory (Cardiovascular) system, Base excess, medicine.symptom, Risk factor, cardiopulmonary bypass, Cardiology and Cardiovascular Medicine, business

الوصف: Background: Cardiac surgery is associated with a substantial risk of major adverse events. Although carbon dioxide (CO2)-derived variables such as venous-to-arterial CO2 difference (ΔPCO2), and PCO2 gap to arterial–venous O2 content difference ratio (ΔPCO2/C(a−cv)O2) have been successfully used to predict the prognosis of non-cardiac surgery, their prognostic value after cardiopulmonary bypass (CPB) remains controversial. This hospital-based study explored the relationship between ΔPCO2, ΔPCO2/C(a−cv)O2 and organ dysfunction after CPB.Methods: We prospectively enrolled 114 intensive care unit patients after elective cardiac surgery with CPB. Patients were divided into the organ dysfunction group (OI) and non-organ dysfunction group (n-OI) depending on whether organ dysfunction occurred or not at 48 h after CPB. ΔPCO2 was defined as the difference between central venous and arterial CO2 partial pressure.Results: The OI group has 37 (32.5%) patients, 27 of which (23.7%) had one organ dysfunction and 10 (8.8%) had two or more organ dysfunctions. No statistical significance was found (P = 0.84) for ΔPCO2 in the n-OI group at intensive care unit (ICU) admission (9.0, 7.0–11.0 mmHg), and at 4 (9.0, 7.0–11.0 mmHg), 8 (9.0, 7.0–11.0 mmHg), and 12 h post admission (9.0, 7.0–11.0 mmHg). In the OI group, ΔPCO2 also showed the same trend [ICU admission (9.0, 8.0–12.8 mmHg) and 4 (10.0, 7.0–11.0 mmHg), 8 (10.0, 8.5–12.5 mmHg), and 12 h post admission (9.0, 7.3–11.0 mmHg), P = 0.37]. No statistical difference was found for ΔPCO2/C(a−cv)O2 in the n-OI group (P = 0.46) and OI group (P = 0.39). No difference was detected in ΔPCO2, ΔPCO2/C(a−cv)O2 between groups during the first 12 h after admission (P > 0.05). Subgroup analysis of the patients with two or more failing organs compared to the n-OI group showed that the predictive performance of lactate and Base excess (BE) improved, but not of ΔPCO2 and ΔPCO2/C(a−cv)O2. Regression analysis showed that the BE at 8 h after admission (odds ratio = 1.37, 95%CI: 1.08–1.74, P = 0.009) was a risk factor for organ dysfunction 48 h after CBP.Conclusion : ΔPCO2 and ΔPCO2/C(a−cv)O2 cannot be used as reliable indicators to predict the occurrence of organ dysfunction at 48 h after CBP due to the pathophysiological process that occurs after CBP.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c10a57f8853784c494236f5ec6c12232Test
https://doi.org/10.3389/fcvm.2021.759826Test

المؤلفون: Wei Chen, Yu Yan, Hong Jun Li, Wei Jiang, YunFei Lei, An Zhang, Qiao Min Li

المصدر: Industrial Robot: the international journal of robotics research and application. 47:90-101

مصطلحات موضوعية: Artificial neural network, Computer science, business.industry, Insulator (electricity), Industrial and Manufacturing Engineering, Computer Science Applications, Electric power system, Control and Systems Engineering, Robot, System integration, Motion planning, business, Robotic arm, Simulation, Configuration design

الوصف: Purpose This study aims to the three major problems of low cleaning efficiency, high labor intensity and difficult to evaluate the cleaning effect for manual insulators cleaning in ultra high voltage (UHV) converter station, the purpose of this paper is to propose a basic configuration of UHV vertical insulator cleaning robot with multi-freedom-degree mechanical arm system on mobile airborne platform and its innovation cleaning operation motion planning. Design/methodology/approach The main factors affecting the insulators cleaning effect in the operation process have been analyzed. Because of the complex coupling relationship between the influencing factors and the insulators cleaning effect, it is difficult to establish its analytical mathematical model. Combining the non-linear mapping and approximation characteristics of back propagation (BP) neural network, the insulator cleaning effect evaluation can be abstracted as a non-linear approximation process from actual cleaning effect to ideal cleaning effect. An evaluation method of robot insulator cleaning effect based on BP neural network has been proposed. Findings Through the BP neural network training, the robot cleaning control parameters can be obtained and used in the robot online operation control, so that the better cleaning effect can be also obtained. Finally, a physical prototype of UHV vertical insulator cleaning robot has been developed, and the effectiveness and engineering practicability of the proposed robot configuration, cleaning effect evaluation method are all verified by simulation experiments and field operation experiments. At the same time, this method has the remarkable characteristics of sound versatility, strong adaptability, easy expansion and popularization. Originality/value An UHV vertical insulator cleaning robot operation system platform with multi-arm system on airborne platform has been proposed. Through the coordinated movement of the manipulator each joint, the manipulator can be positioned to the insulator strings, and the insulator can be cleaned by two pairs high-pressure nozzles located at the double manipulator. The influence factors of robot insulator cleaning effect have been analyzed. The BP neural network model of insulator cleaning effect evaluation has been established. The evaluation method of robot insulator cleaning effect based on BP neural network has also been proposed, and the corresponding evaluation result can be obtained through the network training. Through the system integration design, the robot physical prototype has been developed. For the evaluation of other operation effects of power system, the validity and engineering practicability of the robot mechanism, motion planning and the method for evaluating the effect of robot insulator cleaning have been verified by simulation and field operation experiments.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::97cc8e91b3e67e3630a8ec1d3967e463Test
https://doi.org/10.1108/ir-08-2019-0167Test

المؤلفون: Linqing Wang, Mengtao Ma, Rui Wang, Qiao-min Ru, Jing Wang, Shuang Wei, Yuan Wang, Xin Liu, Chao-zhen-yi Han, Kai Li

المصدر: ACS chemical neuroscience. 12(16)

مصطلحات موضوعية: Physiology, medicine.drug_class, Cognitive Neuroscience, Analgesic, Receptors, Opioid, mu, Pharmacology, Biochemistry, chemistry.chemical_compound, Mice, Opioid receptor, hemic and lymphatic diseases, Medicine, Animals, Opioid peptide, neoplasms, Pain, Postoperative, Microglia, Morphine, business.industry, Cell Biology, General Medicine, Drug Tolerance, Analgesics, Opioid, Nociception, medicine.anatomical_structure, chemistry, Receptors, Purinergic P2X7, Signal transduction, business, Endomorphin, medicine.drug, Signal Transduction

الوصف: The clinical treatment of chronic postoperative pain (CPSP) remains challenging. The side effects of chronic morphine treatment limit its clinical application. MEL-0614, a novel endomorphin analogue that is highly selective and agonistic for μ opioid receptor (MOR), produces a more powerful analgesic effect than that of morphine. In this study, we explored the difference in antinociceptive tolerance and related mechanisms between MEL-0614 and morphine in CPSP induced in a skin/muscle incision and retraction (SMIR) mice model. We found that acute administration of MEL-0614 (1, 3, 5, and 10 nmol, i.t.) produced a dose-dependent analgesic effect that was superior to that of morphine in the SMIR mice model. Long-term MEL-0614 treatment (10 nmol, i.t.) did not induce tolerance compared with morphine. Notably, tolerance induced by morphine could be greatly prevented and/or inhibited via cross-administration or coadministration between MEL-0614 and morphine. In addition, MEL-0614 accelerated the recovery of postoperative pain, whereas morphine aggravated postoperative pain and prolonged its recovery time regardless of preoperative or postoperative treatment. In addition, MEL-0614 did not activate microglia and the P2X7R signaling pathway and showed reduced expression iba1 and P2X7R compared with that observed after morphine administration. Release of inflammatory factors was induced by continued administration of morphine during SMIR surgery, but MEL-0614 did not promote the activation of inflammatory factors. Our results showed that MEL-0614 has superior analgesic effects in CPSP and leads to tolerance to a lesser degree than morphine. Further, MEL-0614 may be used as a promising treatment option for the long-term treatment in CPSP.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59237d1de1236a331b7051630538ae09Test
https://pubmed.ncbi.nlm.nih.gov/34351126Test

المؤلفون: Jinqing Li, Cheng Sun, Yulan Weng, Dan-Ni Zeng, Mingyu Liu, Qiao-Min Hua, Jin-Hua Huang, Minshan Chen, Zhenhong Guo, Shufeng Luo, Li Xu, Jian Zhou, Shi-Mei Zhuang, Jing Liao, Chong Wu, Jie Lin, Chao Liu, Limin Zheng, Chao-Qun Liu, Jing Xu

المصدر: J Clin Invest

مصطلحات موضوعية: 0301 basic medicine, Oncology, Adult, Male, medicine.medical_specialty, Myeloid, Carcinoma, Hepatocellular, Adolescent, T cell, Disease-Free Survival, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Biomarkers, Tumor, Humans, Myeloid Cells, Aged, Aged, 80 and over, Proportional hazards model, business.industry, Gene Expression Profiling, Liver Neoplasms, General Medicine, Nomogram, Middle Aged, Sorafenib, medicine.disease, Gene Expression Regulation, Neoplastic, Survival Rate, 030104 developmental biology, medicine.anatomical_structure, Tumor progression, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Female, Clinical Medicine, Liver cancer, business, CD8

الوصف: BACKGROUND: Despite an increasing appreciation of the roles that myeloid cells play in tumor progression and therapy, challenges remain in interpreting the tumor-associated myeloid response balance and its translational value. We aimed to construct a simple and reliable myeloid signature for hepatocellular carcinoma (HCC). METHODS: Using in situ immunohistochemistry, we assessed the distribution of major myeloid subtypes in both peri- and intratumoral regions of HCC. A 2-feature-based, myeloid-specific prognostic signature, named the myeloid response score (MRS), was constructed using an L1-penalized Cox regression model based on data from a training subset (n = 244), a test subset (n = 244), and an independent internal (n = 341) and 2 external (n = 94; n = 254) cohorts. RESULTS: The MRS and the MRS-based nomograms displayed remarkable discriminatory power, accuracy, and clinical usefulness for predicting recurrence and patient survival, superior to current staging algorithms. Moreover, an increase in MRS was associated with a shift in the myeloid response balance from antitumor to protumor activities, accompanied by enhanced CD8(+) T cell exhaustion patterns. Additionally, we provide evidence that the MRS was associated with the efficacy of sorafenib treatment for recurrent HCC. CONCLUSION: We identified and validated a simple myeloid signature for HCC that showed remarkable prognostic potential and may serve as a basis for the stratification of HCC immune subtypes. FUNDING: This work was supported by the National Science and Technology Major Project of China, the National Natural Science Foundation of China, the Science and Information Technology of Guangzhou, the Fundamental Research Funds for the Central Universities, the Guangdong Basic and Applied Basic Research Foundation, and the China Postdoctoral Science Foundation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::021f2aa3938c13b07a69ecf742842984Test
https://pubmed.ncbi.nlm.nih.gov/32497024Test

المؤلفون: Zhiyu Xiao, Jing Liao, Wei-Ping Wen, Limin Zheng, Chuanchao He, Jin-Zhu Li, Yifan Chu, Dan-Ni Zeng, Qiao-Min Hua, Kai Mao, Yan Wu, Ling-Yan Zhu

المصدر: Hepatology international. 14(1)

مصطلحات موضوعية: Sorafenib, Adult, Male, Carcinoma, Hepatocellular, Adolescent, medicine.medical_treatment, T cell, Antineoplastic Agents, Adenosinergic, 03 medical and health sciences, Mice, Young Adult, 0302 clinical medicine, Immune system, Cell Line, Tumor, Tumor Microenvironment, Medicine, Animals, Humans, Aged, Aged, 80 and over, Tumor microenvironment, Hepatology, business.industry, Liver Neoplasms, Immunotherapy, Middle Aged, Survival Analysis, digestive system diseases, Mice, Inbred C57BL, Disease Models, Animal, medicine.anatomical_structure, Tumor progression, 030220 oncology & carcinogenesis, Cancer research, 030211 gastroenterology & hepatology, Female, business, CD8, medicine.drug

الوصف: Sorafenib is the most widely used first-line treatment for patients with advanced hepatocellular carcinoma (HCC), but such treatment provides only limited survival benefits that might be related to the immune status of distinct tumor microenvironments. A fundamental understanding of the distribution and phenotypes of T lymphocytes in tumors will undoubtedly lead to the development of novel immunotherapeutic strategies that could possibly enhance the efficacy of sorafenib treatments. Flow cytometry, immunohistochemistry and immunofluorescence analyses were performed to detect the infiltration and distribution of various leukocyte populations, and the expression of different immune checkpoint molecules in fresh HCC tumor tissues. Correlations among indicating genes were calculated in 365 patients with HCC from The Cancer Genome Atlas (TCGA) data set, and the cumulative overall survival time was calculated using the Kaplan–Meier method. Moreover, role of adenosinergic pathway on sorafenib anti-tumor efficacy was investigated using both subcutaneous and orthotopic transplantation tumor model in immune competent C57BL/6 mice. We revealed that levels of CD3+ and CD8+ T cells were significantly downregulated in HCC tumor tissue, so were the infiltration of CD169+ cells (a Mφ subpopulation with T cell activation capacities) and their contact with CD8+ cells in tumor milieus. Moreover, levels of PD-1 and CD39 expression were significantly upregulated in human HCC-infiltrating CD4+ and CD8+ T cells, and CD39+CD8+ T cells exhibited a CD69+PD-1+perforinlowIFNγlow “exhausted” phenotype. Levels of both CD39+ T cells infiltration and adenosine receptor ADORA2B expression in tumor tissues were negatively correlated with overall survival of patients with HCC. Accordingly, mice treated with sorafenib in combination with adenosine A2B receptor blockage reagents exhibited significantly reduced tumor progression compared with control groups. These results suggest that adenosinergic pathway might represent an applicable target for sorafenib-combined-therapies in human HCC.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ad1615a672da2e66b491d9a843ba804Test
https://pubmed.ncbi.nlm.nih.gov/31802389Test

المؤلفون: Zheng Fang, Qiao-min Nie, Zhi Tang, Jun-heng Wang

المصدر: Procedia Engineering. 211:726-735

مصطلحات موضوعية: Scale (ratio), business.industry, 0211 other engineering and technologies, Mist, Natural ventilation, 02 engineering and technology, General Medicine, Working pressure, Water pressure, Computational fluid dynamics, 010502 geochemistry & geophysics, 01 natural sciences, Fire smoke, law.invention, law, Ventilation (architecture), Environmental science, business, 021101 geological & geomatics engineering, 0105 earth and related environmental sciences, Marine engineering

الوصف: Computational Fluid Dynamics (CFD) is a useful tool in tunnel fire safety, providing reliable data as a supplement and extension of experiments. In this work, simulations of reduced-scale tunnel fire experiments, concerning in a concrete tunnel model with a scale of 1/3, are presented. It mainly focuses on evaluating the quality of the CFD results. The results show that the simulations consist with the experiments with natural ventilation and longitudinal ventilation. Extension tests are also presented, considering the length and the working pressure of the water mist zone under longitudinal ventilation. It concludes that the downstream temperatures decrease with the length of water mist zone, and no pronouncedly change is obtained as water pressure increases under longitudinal ventilation.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c8bf88c2cce64b8c6bfe6764f62c0bc6Test
https://doi.org/10.1016/j.proeng.2017.12.069Test

المؤلفون: Hai-Xiang Ni, Xiao Lu, Qiao-Min Wu

المصدر: Asian Pacific Journal of Tropical Medicine. 9:893-897

مصطلحات موضوعية: medicine.medical_specialty, Adipokine, Adipose tissue, 030209 endocrinology & metabolism, 030204 cardiovascular system & hematology, 03 medical and health sciences, Diabetes mellitus, 0302 clinical medicine, Internal medicine, medicine, Sitagliptin, Phosphatidylcholine 3-kinase, Chemerin, Adipocytokines, Medicine(all), biology, Adiponectin, business.industry, Leptin, nutritional and metabolic diseases, General Medicine, medicine.disease, Streptozotocin, Endocrinology, biology.protein, business, medicine.drug

الوصف: Objective To study the effect of sitagliptin on adipocytokines expression in diabetic rats and its molecular mechanism. Methods Male SD rats were chosen and randomly divided into NC group, T2DM group, SP group and SP + LY group. NC group received conventional breeding, T2DM group, SP group and SP + LY group received intraperitoneal injection of streptozotocin after 12 weeks of high-fat diet to establish diabetes animal model, SP group received sitagliptin intervention and SP + LY group received sitagliptin combined with PI3K inhibitor LY294002 intervention. Six weeks after the intervention, serum was collected to determine the levels of biochemical indexes and adipocytokines, and visceral adipose tissue was collected to determine expression levels of adipocytokines. Results Serum TC, TG, LDL-C, FBG, FINS, Leptin and Chemerin levels as well as HOMA-IR of T2DM group were higher than those of NC group, and HDL-C, Adiponectin and Omentin-1 levels were significantly lower than those of NC group; serum TC, TG, LDL-C, FBG, FINS, Leptin and Chemerin levels as well as HOMA-IR of SP group were lower than those of T2DM group, and HDL-C, Adiponectin and Omentin-1 levels were significantly higher than those of T2DM group; Leptin and Chemerin levels in serum and visceral adipose tissue of SP + LY group were higher than those of SP group while Adiponectin and Omentin-1 levels were significantly lower than those of SP group. Conclusion Sitagliptin can regulate the expression of adipocytokines in adipose tissue of diabetic rats through PI3K-AKT pathway.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e4ea61b7df69108c9ca881002e8b390Test
https://doi.org/10.1016/j.apjtm.2016.07.014Test

المؤلفون: Huang Jianhui, Huang Pingping, Zhu Yong, Qiao Min, Yuqing Guo

المصدر: ACL (1)

مصطلحات موضوعية: Computer science, Ground, business.industry, Association (object-oriented programming), Object level, 02 engineering and technology, 010501 environmental sciences, computer.software_genre, 01 natural sciences, 0202 electrical engineering, electronic engineering, information engineering, Benchmark (computing), Question answering, 020201 artificial intelligence & image processing, Artificial intelligence, business, computer, Natural language processing, 0105 earth and related environmental sciences

الوصف: Attention mechanisms are widely used in Visual Question Answering (VQA) to search for visual clues related to the question. Most approaches train attention models from a coarse-grained association between sentences and images, which tends to fail on small objects or uncommon concepts. To address this problem, this paper proposes a multi-grained attention method. It learns explicit word-object correspondence by two types of word-level attention complementary to the sentence-image association. Evaluated on the VQA benchmark, the multi-grained attention model achieves competitive performance with state-of-the-art models. And the visualized attention maps demonstrate that addition of object-level groundings leads to a better understanding of the images and locates the attended objects more precisely.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fc3dcfa284c174c42bab7ef62aeb2daeTest
https://doi.org/10.18653/v1/p19-1349Test