المؤلفون: Mahyar Osanlouy, Anita Bandrowski, Bernard de Bono, David Brooks, Antonino M. Cassarà, Richard Christie, Nazanin Ebrahimi, Tom Gillespie, Jeffrey S. Grethe, Leonardo A. Guercio, Maci Heal, Mabelle Lin, Niels Kuster, Maryann E. Martone, Esra Neufeld, David P. Nickerson, Elias G. Soltani, Susan Tappan, Joost B. Wagenaar, Katie Zhuang, Peter J. Hunter

المصدر: Frontiers in Physiology, Vol 12 (2021)
Frontiers in Physiology, 12
Frontiers in Physiology

مصطلحات موضوعية: 0301 basic medicine, Computer science, Physiology, Interface (computing), Medical Physiology, computational life sciences, Bioengineering, Resource center, 03 medical and health sciences, Upload, 0302 clinical medicine, Resource (project management), Physiology (medical), Methods, QP1-981, Psychology, Segmentation, FAIR, data curation, Information retrieval, Data curation, business.industry, autonomic nervous system, Semantic search, Neurosciences, Experimental data, SPARC, neural mapping, knowledge management, Data portal, 030104 developmental biology, data annotation, business, 030217 neurology & neurosurgery

الوصف: The Data and Resource Center (DRC) of the NIH-funded SPARC program is developing databases, connectivity maps, and simulation tools for the mammalian autonomic nervous system. The experimental data and mathematical models supplied to the DRC by the SPARC consortium are curated, annotated and semantically linked via a single knowledgebase. A data portal has been developed that allows discovery of data and models both via semantic search and via an interface that includes Google Map-like 2D flatmaps for displaying connectivity, and 3D anatomical organ scaffolds that provide a common coordinate framework for cross-species comparisons. We discuss examples that illustrate the data pipeline, which includes data upload, curation, segmentation (for image data), registration against the flatmaps and scaffolds, and finally display via the web portal, including the link to freely available online computational facilities that will enable neuromodulation hypotheses to be investigated by the autonomic neuroscience community and device manufacturers.
Frontiers in Physiology, 12
ISSN:1664-042X

وصف الملف: application/pdf; application/application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b94654cd5b69736de7e07d2030a3d67Test
https://escholarship.org/uc/item/5dh65320Test

المؤلفون: Heath D. Schmidt, Leonardo A. Guercio, Sarah E. Swinford-Jackson, Mathieu E. Wimmer, R. Christopher Pierce, Fair M. Vassoler

المصدر: Brain Res

مصطلحات موضوعية: 0301 basic medicine, Male, Deep brain stimulation, media_common.quotation_subject, medicine.medical_treatment, Deep Brain Stimulation, Infralimbic cortex, Drug-Seeking Behavior, Hippocampus, Nucleus accumbens, behavioral disciplines and activities, Article, Rats, Sprague-Dawley, 03 medical and health sciences, Glutamatergic, Cocaine-Related Disorders, 0302 clinical medicine, Cocaine, Dopamine Uptake Inhibitors, medicine, Animals, Prefrontal cortex, Molecular Biology, media_common, business.industry, General Neuroscience, Addiction, Brain, Rats, 030104 developmental biology, medicine.anatomical_structure, surgical procedures, operative, nervous system, Neurology (clinical), business, Neuroscience, 030217 neurology & neurosurgery, Developmental Biology, Basolateral amygdala

الوصف: Deep brain stimulation (DBS) is a promising therapeutic modality for the treatment of drug craving and addiction. To date, the nucleus accumbens has received the most attention as a potential target region for examining the impact of DBS on cocaine seeking in preclinical models. The present study investigated the effects of DBS in brain regions that send major glutamatergic projections to the nucleus accumbens including the basolateral amygdala (BLA) and ventral hippocampus (vHipp) as well as subregions of the medial prefrontal cortex (mPFC) including the anterior cingulate, infralimbic and prelimbic cortices. The current results showed that DBS in the infralimbic cortex, but not the prelimbic or anterior cingulate cortices, selectively attenuated cocaine-primed reinstatement of drug seeking in rats. The present data also demonstrated that DBS of the BLA and vHipp attenuated the reinstatement of both cocaine and sucrose seeking. These results indicate that the infralimbic cortex may be a suitable target for DBS to prevent relapse of cocaine taking.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0044a167217f27c344d83cdf9e4f0693Test
https://pubmed.ncbi.nlm.nih.gov/32652146Test

المؤلفون: R. Christopher Pierce, Leonardo A. Guercio

المصدر: Innovations in Cognitive Neuroscience ISBN: 9783319427416

مصطلحات موضوعية: Deep brain stimulation, business.industry, Addiction, media_common.quotation_subject, medicine.medical_treatment, Dopaminergic, Glutamatergic, Neurochemical, Dopamine, Detoxification, Medicine, business, Neuroscience, media_common, medicine.drug, Cocaine seeking

الوصف: Cocaine addiction in humans is characterized by persistent relapse vulnerability following detoxification. Relapse to drug taking can be precipitated by several factors: stress, re-exposure to drug-associated environmental cues, and re-exposure to the drug itself. Preclinical studies have focused on cocaine reinstatement, an animal model of relapse, to achieve a greater understanding of the underlying anatomical, neurobiological, and neurochemical bases of cocaine craving and relapse. Here, we review how changes in dopaminergic and glutamatergic transmission in mesocorticolimbic nuclei contribute to the reinstatement of cocaine seeking. This information can be used to elucidate which nuclei may prove effective therapeutic targets for deep brain stimulation (DBS) as a treatment for cocaine craving and relapse.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1692ab425118af2640f2b12f9d7bc45dTest
https://doi.org/10.1007/978-3-319-42743-0_17Test