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المؤلفون: Gunhild Sommer, Marie Matthes, Rebecca Waetzig, Johannes Leister, Selim Corbacioglu, Gina Penkivech, Tilman Heise
المصدر: International Journal of Medical Sciences
مصطلحات موضوعية: Indoles, Combination therapy, mTOR inhibitor, Cell Survival, medicine.medical_treatment, ATP competitive mTOR inhibitors, Dasatinib, P70-S6 Kinase 1, Irinotecan, combination therapy, 03 medical and health sciences, Inhibitory Concentration 50, neuroblastoma, 0302 clinical medicine, Neuroblastoma, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, medicine, Temozolomide, Humans, Rapamycin, Naphthyridines, Protein kinase B, PI3K/AKT/mTOR pathway, Sirolimus, Chemotherapy, Dose-Response Relationship, Drug, business.industry, TOR Serine-Threonine Kinases, Thiourea, Torin-2, Drug Synergism, General Medicine, Cell cycle, medicine.disease, Pyrimidines, Purines, Administration, Metronomic, Cancer research, 030211 gastroenterology & hepatology, Drug Screening Assays, Antitumor, business, medicine.drug, Signal Transduction, Research Paper
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e96a3896cfaaa672126835c7932ea849Test
http://europepmc.org/articles/PMC7738968Test -
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المؤلفون: Linda Partridge, Paula Juricic Dzankic
المصدر: Lancet Healthy Longev
The Lancet. Healthy Longevity, Vol 2, Iss 5, Pp e232-e233 (2021)
The Lancet. Healthy Longevityمصطلحات موضوعية: Aging, Health (social science), MEDLINE, Viral infection, Antiviral Agents, Pulmonary Disease, Chronic Obstructive, Text mining, Immunity, Medicine, Humans, Everolimus, Biology, Pandemics, Respiratory Tract Infections, Aged, rapamycin, business.industry, TOR Serine-Threonine Kinases, Comment, RC952-954.6, COVID-19, MTOR Inhibitors, Discovery and development of mTOR inhibitors, Clinical trial, Psychiatry and Mental health, Treatment Outcome, Diabetes Mellitus, Type 2, Geriatrics, Immunology, Geriatrics and Gerontology, Family Practice, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35cc195be514d194fa3e628e648f19aTest
https://hdl.handle.net/21.11116/0000-000B-2D53-6Test -
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المؤلفون: Mikhail V. Blagosklonny
المصدر: Aging (Albany NY)
مصطلحات موضوعية: Aging, Psychotherapist, fasting, rapalogs, media_common.quotation_subject, Longevity, Life extension, medicine, Humans, media_common, Sirolimus, Health span, Everolimus, Blindness, rapamycin, business.industry, anti-aging, Cell Biology, Immortality, health span, Discovery and development of mTOR inhibitors, medicine.disease, Premature death, Research Perspective, metformin, business, Immunosuppressive Agents, lifespan, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8a1c4f2c60ae22e5deceb599d16f755cTest
https://doi.org/10.18632/aging.102355Test -
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المساهمون: ANS - Cellular & Molecular Mechanisms, APH - Mental Health, APH - Aging & Later Life, Pathology, Graduate School
المصدر: Expert review of neurotherapeutics, 18(3), 185-201. Taylor and Francis Ltd.
مصطلحات موضوعية: 0301 basic medicine, mTOR inhibitors, tuberous sclerosis complex, Epileptogenesis, 03 medical and health sciences, Tuberous sclerosis, Epilepsy, 0302 clinical medicine, Tuberous Sclerosis, Animals, Humans, Medicine, Pharmacology (medical), PI3K/AKT/mTOR pathway, Everolimus, rapamycin, business.industry, TOR Serine-Threonine Kinases, General Neuroscience, epileptogenesis, everolimus, mTORopathies, malformations, Anticonvulsants, Signal Transduction, Discovery and development of mTOR inhibitors, medicine.disease, Settore MED/39, 030104 developmental biology, Neurology (clinical), business, human activities, Neuroscience, 030217 neurology & neurosurgery, medicine.drug
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f85607f68c0fcbb9d482d93c0e8fce76Test
https://doi.org/10.1080/14737175.2018.1428562Test -
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المؤلفون: Guoli Shi, Abhilash I. Chiramel, Tiansheng Li, Kin Kui Lai, Adam D. Kenney, Ashley Zani, Adrian C. Eddy, Saliha Majdoul, Lizhi Zhang, Tirhas Dempsey, Paul A. Beare, Swagata Kar, Jonathan W. Yewdell, Sonja M. Best, Jacob S. Yount, Alex A. Compton
المصدر: bioRxiv
article-version (status) pre
article-version (number) 1مصطلحات موضوعية: Intrinsic immunity, mTOR inhibitor, Cell, membrane fusion, coronavirus, medicine.disease_cause, rapalog, Virus, Article, IFITM, Ridaforolimus, chemistry.chemical_compound, Immune system, Immunopathology, medicine, Influenza A virus, Humans, SARS, Sirolimus, business.industry, rapamycin, SARS-CoV-2, fungi, COVID-19, Membrane Proteins, RNA-Binding Proteins, General Medicine, interferon, MTOR Inhibitors, Virus Internalization, Acquired immune system, Influenza, Immunity, Innate, medicine.anatomical_structure, chemistry, Cancer research, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::681ff4acf303d40082d1e4292bf4dabaTest
https://pubmed.ncbi.nlm.nih.gov/36264642Test -
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المؤلفون: Michela Campolo, Alessio Ardizzone, Marika Lanza, Marika Cordaro, Sarah Adriana Scuderi, Emanuela Esposito, Giovanna Casili, Salvatore Cuzzocrea, Alessia Filippone, Irene Paterniti
المصدر: Journal of Cellular and Molecular Medicine
مصطلحات موضوعية: Male, apoptosis, astrogliosis, behavioural performance, KU0063794, mTOR, mTORC1, mTORC2, neuroinflammation, neuronal death, rapamycin, traumatic brain injury, Necrosis, Traumatic brain injury, Morpholines, Pharmacology, Lesion, Mice, Brain Injuries, Traumatic, Medicine, Animals, Enzyme Inhibitors, Neuroinflammation, PI3K/AKT/mTOR pathway, Cell Proliferation, Neurons, Sirolimus, Cell Death, business.industry, TOR Serine-Threonine Kinases, Cell Biology, Original Articles, MTOR Inhibitors, medicine.disease, nervous system diseases, Astrogliosis, Disease Models, Animal, Pyrimidines, nervous system, Neuroinflammatory Diseases, Molecular Medicine, Original Article, medicine.symptom, business, Immunosuppressive Agents, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1e7c71b99995cf2489cffa15aef7feTest
http://hdl.handle.net/11570/3208354Test -
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المؤلفون: Sanae Nagata, Hiroyuki Yoshitomi, Yonghui Jin, Junya Toguchida, Hirotsugu Maekawa, Shuichi Matsuda, Shunsuke Kawai, Megumi Nishio
المصدر: Orphanet Journal of Rare Diseases
Orphanet Journal of Rare Diseases, Vol 15, Iss 1, Pp 1-11 (2020)مصطلحات موضوعية: 0301 basic medicine, Heterotopic ossification, Mutant, lcsh:Medicine, ACVR1, medicine.disease_cause, Mice, 03 medical and health sciences, 0302 clinical medicine, medicine, Animals, Humans, Pharmacology (medical), Rapamycin, Genetics (clinical), PI3K/AKT/mTOR pathway, Sirolimus, Mutation, business.industry, Ossification, Heterotopic, Research, lcsh:R, General Medicine, Discovery and development of mTOR inhibitors, medicine.disease, 030104 developmental biology, Myositis Ossificans, Fibrodysplasia ossificans progressiva, Cancer research, business, Activin Receptors, Type I, 030217 neurology & neurosurgery, Prophylactic treatment
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c43165bc6e45632dd5fef3eaf9c3b34eTest
https://doi.org/10.1186/s13023-020-01406-8Test -
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المؤلفون: Shunai Liu, Renfeng Li, Yunfeng Zheng
المصدر: Journal of Medical Virology
مصطلحات موضوعية: mTOR inhibitors, medicine.medical_treatment, coronavirus, Reviews, Review, Cross Reactions, medicine.disease_cause, Antibodies, Viral, Virus, Immunomodulation, 03 medical and health sciences, 0302 clinical medicine, cross‐reactive antibody, Immunity, Virology, medicine, Humans, Antibody-dependent enhancement, 030212 general & internal medicine, PI3K/AKT/mTOR pathway, Coronavirus, B-Lymphocytes, business.industry, rapamycin, Mortality rate, TOR Serine-Threonine Kinases, medicine.disease, immunity, Antibody-Dependent Enhancement, COVID-19 Drug Treatment, Clinical trial, Cytokine release syndrome, Cytokine, Infectious Diseases, Immunology, antibody‐dependent enhancement, cytokine storm, 030211 gastroenterology & hepatology, Cytokine storm, business, Cytokine Release Syndrome, ADE
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fde280a6982549836b9aa71b42c2c21dTest
http://europepmc.org/articles/PMC7272823Test -
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المؤلفون: Franco Cortese, Darla Karpinsky-Semper, Alex Zhavoronkov, Leslie C. Jellen, Alexander Aliper, Artem V. Artemov, Andrew G. Swick, Alexey Moskalev
المصدر: Aging (Albany NY)
مصطلحات موضوعية: 0301 basic medicine, Aging, Computational biology, compound screening, Machine Learning, 03 medical and health sciences, chemistry.chemical_compound, Structure-Activity Relationship, 0302 clinical medicine, Databases, Genetic, Drug Discovery, Screening method, Medicine, Humans, Gene Regulatory Networks, Molecular Targeted Therapy, Protein Interaction Maps, Protein Kinase Inhibitors, natural, Sirolimus, Molecular Structure, business.industry, rapamycin, TOR Serine-Threonine Kinases, Molecular Mimicry, deep learning, Computational Biology, Cell Biology, Experimental validation, Geroprotector, Discovery and development of mTOR inhibitors, Metformin, High-Throughput Screening Assays, 030104 developmental biology, Chronic disease, chemistry, 030220 oncology & carcinogenesis, Dietary Supplements, geroprotector, nutraceutical, Neural Networks, Computer, business, Isoliquiritigenin, medicine.drug, Research Paper, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4085f985e3077bd427a25233052bfc2bTest
http://europepmc.org/articles/PMC5723685Test -
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المؤلفون: Hannah E. Walters, Lynne S. Cox
المصدر: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 19, Iss 8, p 2325 (2018)مصطلحات موضوعية: 0301 basic medicine, Aging, senescence, rapalogs, mTORC1, Disease, Review, Bioinformatics, mTORC2, lcsh:Chemistry, Risk Factors, Neoplasms, Medicine, lcsh:QH301-705.5, Spectroscopy, Cellular Senescence, immunosenescence, 0303 health sciences, biology, TOR Serine-Threonine Kinases, neurodegeneration, Neurodegenerative Diseases, General Medicine, Immunosenescence, Computer Science Applications, 3. Good health, Cardiovascular Diseases, mTOR, 0305 other medical science, rapalogues, Senescence, mTOR inhibitors, Catalysis, Inorganic Chemistry, medicine_pharmacology_other, 03 medical and health sciences, 030502 gerontology, Humans, cancer, Physical and Theoretical Chemistry, Molecular Biology, Mechanistic target of rapamycin, PI3K/AKT/mTOR pathway, 030304 developmental biology, Mechanism (biology), business.industry, rapamycin, Organic Chemistry, biomarkers, 030104 developmental biology, lcsh:Biology (General), lcsh:QD1-999, Ageing, ageing, senolytics, biology.protein, business
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26207dfed5bf4ebaf566d1815e6c7856Test