Evaluation of Iron Deposition in the Adrenal Glands of β Thalassemia Major Patients Using 3-Tesla MRI
| العنوان: | Evaluation of Iron Deposition in the Adrenal Glands of β Thalassemia Major Patients Using 3-Tesla MRI |
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| المؤلفون: | Tevfik Guzelbey, Aysegul Sarsilmaz, Ebru Karasu, Bengi Gürses, Erman Öztürk, Olcay Ozveren |
| المساهمون: | Gürses, Bengi, Öztürk, Erman, Güzelbey, Tevfik, Özveren, Olcay, Sarsılmaz, Ayşegül, Karasu, Ebru, School of Medicine, Department of Radiology, Department of Hematology, Guzelbey, T., Gurses, B., Ozturk, E., Ozveren, O., Sarsilmaz, A., Karasu, E., Yeditepe Üniversitesi |
| المصدر: | Iranian Journal of Radiology |
| بيانات النشر: | Briefland, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Relaxation, Relaxometry, medicine.medical_specialty, Pathology, Blood transfusion, medicine.medical_treatment, Thalassemia, Medicine, Radiology, Hematology, Adrenal glands, Gastroenterology, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, Magnetic resonance imaging, 0302 clinical medicine, Internal medicine, Adrenal Glands, medicine, Abdominal Imaging, Radiology, Nuclear Medicine and imaging, Chelation therapy, medicine.diagnostic_test, biology, Adrenal gland, business.industry, medicine.disease, Magnetic Resonance Imaging, Kowsar, Ferritin, medicine.anatomical_structure, biology.protein, Nuclear medicine and medical imaging, business, 030215 immunology |
| الوصف: | Background: Beta-thalassemia major (beta-TM) patients need blood transfusions, which result in iron deposition. To regulate chelation therapy, iron load has to be measured. With MRI, the amount of signal loss and T2* decay time shortening are used for iron quantification. Objectives: The aim was to measure adrenal iron load with T2* relaxometry using MRI, and to compare it with liver and cardiac iron and serum ferritin, and to find out whether adrenal iron could be predicted from those parameters. Patients and Methods: Between October 2014 and March 2015, MRI was performed in 21 patients with beta-TM, recieving blood transfusions and chelation therapy. The control group (n = 11) included healthy volunteers with no known history of adrenal, hematologic, chronic disease, and blood transfusion. Results: Among patients, there was no significant correlation between plasma ferritin and adrenal T2*. Significant difference was detected among T2* values of adrenals between the patient and control groups. There was no significant correlation between adrenal gland and liver T2* in beta-TM patients, moderate correlation was detected between adrenal T2* and cardiac T2*. Conclusion: Adrenal iron in beta-TM can be reliably measured in 3 Tesla MRI. The results highlight the absence of correlation between adrenal iron deposition both with serum ferritin and hepatic iron. NA |
| وصف الملف: | |
| تدمد: | 2008-2711 1735-1065 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5dac842d799c156e8890aa8531df8faTest https://doi.org/10.5812/iranjradiol.36375Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b5dac842d799c156e8890aa8531df8fa |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20082711 17351065 |
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