المؤلفون: Ronald M. Lechan, Theodore L. Munsat, Lester S. Adelman, John J. Kelly, Ivor M. D. Jackson, Peter van den Bergh

المصدر: Muscle & Nerve. 10:397-405

مصطلحات موضوعية: Male, endocrine system, medicine.medical_specialty, Physiology, 5,7-Dihydroxytryptamine, Motor Activity, Cellular and Molecular Neuroscience, Gastrocnemius muscle, Physiology (medical), Internal medicine, medicine, Animals, Neurotoxin, Dihydroxytryptamines, Thyrotropin-Releasing Hormone, Lumbar cord, Motor Neurons, Denervation, business.industry, Muscles, Rats, Inbred Strains, Anatomy, Spinal cord, Rats, Endocrinology, medicine.anatomical_structure, Spinal Cord, Excitatory postsynaptic potential, Neurology (clinical), business, hormones, hormone substitutes, and hormone antagonists, TRH DEFICIENCY, Hormone

الوصف: Thyrotropin-releasing hormone (TRH), present in high concentrations in the mammalian spinal cord, exerts excitatory effects on the alpha-motorneuron (AMN) via axodendritic contacts. We used the neurotoxin 5,7-dihydroxytryptamine (5,7-DHT) to deplete TRH from the ventral horn of the spinal cord of adults rats to determine whether the tripeptide may be trophic to the AMN. The rats were studied blindly and sequentially for 11 weeks. Motor performance remained normal by clinical and electrophysiologic assessments. AMN counts were not reduced in the lumbar cord, and gastrocnemius muscle showed no evidence of denervation in treated rats. We conclude that in the adult rat chronic ventral horn TRH deficiency does not lead to AMN degeneration and is not associated with a significant alteration of AMN function.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1289d912927a587ca989b1d7ee82aa20Test
https://doi.org/10.1002/mus.880100504Test

المؤلفون: Peter Van den Bergh, Eric L. Logigian, John J. Kelly

المصدر: Musclenerve. 12(1)

مصطلحات موضوعية: Neural Conduction, Motor Neurons, Pathology, medicine.medical_specialty, Adolescent, Physiology, business.industry, Motor nerve, Polyradiculoneuropathy, Neuromuscular Diseases, Sural nerve biopsy, medicine.disease, Nerve conduction velocity, Electrophysiology, Cellular and Molecular Neuroscience, Physiology (medical), medicine, Humans, Female, Neurology (clinical), Demyelinating polyneuropathy, business, Motor neuropathy

الوصف: We describe a patient with a chronic, symmetric, monophasic, acquired, pure motor, demyelinating polyneuropathy. Electrodiagnostic studies showed the presence of multifocal conduction blocks in motor nerves at sites not prone to compression. A sural nerve biopsy was normal. The patient responded to immunosuppressive therapy and plasma exchange. We postulate that this disorder is an unusual variant of chronic inflammatory polyradiculoneuropathy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34512807635f7a49cb64fc30e6d1d13aTest
https://pubmed.ncbi.nlm.nih.gov/2747734Test

المؤلفون: John Willis, Peter Van den Bergh

المصدر: Journal of child neurology. 3(3)

مصطلحات موضوعية: Male, medicine.medical_specialty, Polyradiculoneuropathy, Sensation, Gastroenterology, Synaptic Transmission, 03 medical and health sciences, 0302 clinical medicine, 030225 pediatrics, Internal medicine, medicine, Reaction Time, Humans, Peripheral Nerves, Cerebral dysfunction, Child, Motor Neurons, business.industry, Brain, Surgery, Acute Inflammatory Demyelinating Polyneuropathy, Child, Preschool, Pediatrics, Perinatology and Child Health, Relapsing inflammatory polyneuropathy, Demyelinating neuropathy, Evoked Potentials, Auditory, Neurology (clinical), business, 030217 neurology & neurosurgery, Brain Stem

الوصف: We present two children with seizures and other signs of cerebral involvement at the outset of acute inflammatory demyelinating polyneuropathy, consistent with a diagnosis of encephalomyeloradiculoneuropathy. One child had a recurrence associated with mild central dysfunction and improved during therapy with corticosteroids. Both children recovered completely. Both acute and relapsing inflammatory demyelinating neuropathy may be accompanied by cerebral dysfunction, expanding the clinical spectrum of encephalomyeloradiculoneuropathy. ( Child Neurol 1988;3:200-204).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55e9ab924cc49ec3a2bd6f4dfbdf45f4Test
https://pubmed.ncbi.nlm.nih.gov/2850316Test