نتائج البحث - "Neuropilin 1"

1

Neuropilin 1: A Novel Entry Factor for SARS-CoV-2 Infection and a Potential Therapeutic Target

المؤلفون: Chekol Abebe, Endeshaw, Mengie Ayele, Teklie, Tilahun Muche, Zelalem, Asmamaw Dejenie, Tadesse

المصدر: Biologics : Targets & Therapy

الوصف: The novel coronavirus disease 2019 (COVID-19) pandemic is severely challenging the healthcare systems and economies of the world, which urgently demand vaccine and therapy development to combat severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Hence, advancing our understanding of the comprehensive entry mechanisms of SARS-CoV-2, especially the host factors that facilitate viral infection, is crucial for the discovery of effective vaccines and antiviral drugs. SARS-CoV-2 has previously been documented to reach cells by binding with ACE2 and CD147 receptors in host cells that interact with the spike (S) protein of SARS-CoV-2. A novel entry factor, called neuropilin 1(NRP1), has recently been discovered as a co-receptor facilitating the entry of SARS-CoV-2. NRP1 is a single-pass transmembrane glycoprotein widely distributed throughout the tissues of the body and acts as a multifunctional co-receptor to bind with different ligand proteins and play diverse physiological roles as well as pathological and therapeutic roles in different clinical conditions/diseases, including COVID-19. The current review, therefore, briefly provides the overview of SARS-CoV-2 entry mechanisms, the structure of NRP1, and their roles in health and various diseases, as well as extensively discusses the current understanding of the potential implication of NRP1 in SARS-CoV-2 entry and COVID-19 treatment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::664f0372bf9d6f036b00c351a875f460Test
https://doi.org/10.2147/btt.s307352Test

2

The semaphorin 4A–neuropilin 1 axis alleviates kidney ischemia reperfusion injury by promoting the stability and function of regulatory T cells

المؤلفون: Xiubin Li, Yuanyu Zhao, Bo Yu, Xing Wei, Qing Yuan, Chenfeng Wang, Xu Liang, Xu Zhang, Haitao Liu, Xiang Li, Zhekun An, Ming Cai, Xin Ma, Junnan Xu

المصدر: Kidney International. 100:1268-1281

مصطلحات موضوعية: Cell type, Renal ischemia, business.industry, Ischemia, FOXP3, hemic and immune systems, chemical and pharmacologic phenomena, medicine.disease, Proinflammatory cytokine, Semaphorin, Nephrology, Neuropilin 1, medicine, Cancer research, business, Reperfusion injury

الوصف: Previous studies have suggested the role of CD4+Foxp3+ regulatory T cells (Tregs) in protection against kidney ischemia reperfusion injury via their immunosuppressive properties. Unfortunately, the associated mechanisms of Tregs in kidney ischemia reperfusion injury have not been fully elucidated. Semaphorin 4A (Sema4A) is essential for maintaining the immunosuppressive capacity of Tregs in tumors. However, whether Sema4A can alleviate kidney ischemia reperfusion injury through Tregs has not yet been demonstrated. Here, we investigated the effect and mechanism of Sema4A on the development of kidney ischemia reperfusion injury. Administration of recombinant human Sema4A-Fc chimera protein prior to ischemia reperfusion injury promoted the expansion and function of Tregs and decreased the accumulation of neutrophils and proinflammatory macrophages thereby attenuating functional and histological injury of the injured kidneys. Depletion of Tregs abrogated the protective effect of Sema4A on kidney ischemia reperfusion injury, suggesting Tregs as the main target cell type for Sema4A in the development of this injury. Mechanistically, Sema4A bound to neuropilin 1 (Nrp1), a cell surface receptor for Sema4A and other ligands and a key regulator of Tregs, which then promoted recruitment of phosphatase and tensin homologue and suppressed the Akt–mTOR pathway in Foxp3Cre mice but not in Nrp1f/f Foxp3Cre mice. Consistently, Treg-specific deletion of Nrp1 blocked the effect of Sema4A on the expansion and function of Treg cells. Thus, our results demonstrate that the Sema4A–Nrp1 axis alleviates the development of ischemia reperfusion injury by promoting the stability and function of Tregs in mouse kidneys.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::63df19f13a57927258ce8552fd8f2471Test
https://doi.org/10.1016/j.kint.2021.08.023Test

3

Emerging Role of Neuropilin-1 and Angiotensin-Converting Enzyme-2 in Renal Carcinoma-Associated COVID-19 Pathogenesis

المؤلفون: Golzar Hossain, Jamal Uddin, Sharmin Akter

المصدر: Infectious Disease Reports, Vol 13, Iss 81, Pp 902-909 (2021)
Infectious Disease Reports

الوصف: Neuropilin-1 (NRP1) is a recently identified glycoprotein that is an important host factor for SARS-CoV-2 infection. On the other hand, angiotensin-converting enzyme-2 (ACE2) acts as a receptor for SARS-CoV-2. Additionally, both NRP1 and ACE2 express in the kidney and are associated with various renal diseases, including renal carcinoma. Therefore, the expression profiles of NRP1 and ACE2 in kidney renal clear cell carcinoma (KIRC) and kidney renal papillary cell carcinoma (KIRP) patients from the various cancer databases were investigated along with their impact on patients’ survivability. In addition, coexpression analysis of genes involved in COVID-19, KIRC, and KIRP concerning NRP1 and ACE2 was performed. The results demonstrated that both t NRP1 and ACE2 expressions are upregulated in KIRC and KIRP compared to healthy conditions and are significantly correlated with the survivability rate of KIRC patients. A total of 128 COVID-19-associated genes are coexpressed, which are positively associated with NRP1 and ACE2 both in KIRC and KIRP. Therefore, it might be suggested that, along with the ACE2, high expression of the newly identified host factor NRP1 in renal carcinomas may play a vital role in the increased risk of SARS-CoV-2 infection and survivability of COVID-19 patients suffering from kidney cancers. The findings of this investigation will be helpful for further molecular studies and prevention and/or treatment strategies for COVID-19 patients associated with renal carcinomas.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a141d42879b2a77717e23eb2ac92786fTest
https://www.mdpi.com/2036-7449/13/4/81Test

4

The Antiviral Roles of Hydrogen Sulfide by Blocking the Interaction between SARS-CoV-2 and Its Potential Cell Surface Receptors

المؤلفون: Sheng Jin, Jing Dai, Yuming Wu, Xu Teng

المصدر: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)

مصطلحات موضوعية: Aging, Receptors, Cell Surface, Transferrin receptor, Review Article, Protective Agents, Antiviral Agents, Biochemistry, Cell surface receptor, Neuropilin 1, Animals, Humans, Medicine, Hydrogen Sulfide, Receptor, QH573-671, SARS-CoV-2, business.industry, Cell Biology, General Medicine, Entry into host, Pathophysiology, Organ Specificity, Immunology, Cytology, business

الوصف: The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is posing a great threat to the global economy and public health security. Together with the acknowledged angiotensin-converting enzyme 2, glucose-regulated protein 78, transferrin receptor, AXL, kidney injury molecule-1, and neuropilin 1 are also identified as potential receptors to mediate SARS-CoV-2 infection. Therefore, how to inhibit or delay the binding of SARS-CoV-2 with the abovementioned receptors is a key step for the prevention and treatment of COVID-19. As the third gasotransmitter, hydrogen sulfide (H2S) plays an important role in many physiological and pathophysiological processes. Recently, survivors were reported to have significantly higher H2S levels in COVID-19 patients, and mortality was significantly greater among patients with decreased H2S levels. Considering that the beneficial role of H2S against COVID-19 and COVID-19-induced comorbidities and multiorgan damage has been well-examined and reported in some excellent reviews, this review will discuss the recent findings on the potential receptors of SARS-CoV-2 and how H2S modulates the above receptors, in turn blocking SARS-CoV-2 entry into host cells.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36a0388ca7e1e28c904d503910116ce5Test
https://doi.org/10.1155/2021/7866992Test

5

Semaphorins: From Angiogenesis to Inflammation in Rheumatoid Arthritis

المؤلفون: Eloise Vandebeuque, Virginie Gonzalez, Grégory Marin, Yannick Allanore, Claire Daien, Sonia Pezet, Jérôme Avouac, Gaël Mouterde, Cindy Orvain

المصدر: Arthritis & Rheumatology. 73:1579-1588

الوصف: OBJECTIVE To study the potential role of semaphorins in the pathogenesis of rheumatoid arthritis (RA). METHODS Microarray experiments were performed on Affymetrix GeneChip Human Exon 1.0 ST arrays in RA endothelial cells (ECs) and control ECs derived from circulating progenitors. Expression of class 3 and class 4 semaphorins and their receptors in the serum of RA patients and healthy controls was assessed by immunohistochemical analysis in synovial tissue and by enzyme-linked immunosorbent assay. RESULTS Microarray analysis revealed differential expression of class 3 and class 4 semaphorins and their receptors in RA ECs. Semaphorin 4A (SEMA4A), plexin D1, and neuropilin 1 messenger RNA (mRNA) levels were markedly increased in RA ECs by 1.75-, 2.21-, and 1.68-fold, respectively. Stimulation with tumor necrosis factor (TNF) led to a 2-fold increase in SEMA4A mRNA levels in RA ECs, and deficient SEMA4A expression modified RA EC angiogenic properties. Class 3 and class 4 semaphorins as well as their receptors were overexpressed in RA synovial tissue. A respective 1.30-fold increase and 1.54-fold increase in SEMA4A and SEMA3E, as well as a 24% decrease in SEMA3A, was observed in the serum of RA patients. Serum levels of SEMA4A, SEMA4D, and SEMA3A correlated with levels of inflammation and proangiogenic markers. In 2 independent cohorts of patients with low disease activity or with RA in remission, the presence of SEMA4A identified patients with residual disease activity. CONCLUSION Gene expression profiling of ECs identified class 3 and class 4 semaphorins as potential biomarkers and therapeutic candidates in RA, with confirmed overexpression in ECs, synovial vessels, and serum, and correlation with validated markers of inflammation and angiogenesis. Thus, semaphorins might be novel and appealing EC-derived inflammatory and proangiogenic targets in RA.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7da3373e7f50966dd48371cd647c825Test
https://doi.org/10.1002/art.41701Test

6

In silico analysis identifies neuropilin-1 as a potential therapeutic target for SARS-Cov-2 infected lung cancer patients

المؤلفون: Chuwen Lin, Xuan Jiang, Zheyu Hu, Song Hu, Jiajia Qin

المصدر: Aging (Albany NY)

مصطلحات موضوعية: Aging, Lung, SARS-CoV-2, immune infiltration, business.industry, T cell, Cell, COVID-19, Cell Biology, respiratory system, urologic and male genital diseases, medicine.disease, TMPRSS2, medicine.anatomical_structure, Neuropilin 1, medicine, Cancer research, NRP1, Adenocarcinoma, Lung cancer, business, CD8, Research Paper, miRNA

الوصف: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19), and is highly contagious and pathogenic. TMPRSS2 and Neuropilin-1, the key components that facilitate SARS-CoV-2 infection, are potential targets for treatment of COVID-19. Here we performed a comprehensive analysis on NRP1 and TMPRSS2 in lung to provide information for treating comorbidity of COVID-19 with lung cancer. NRP1 is widely expressed across all the human tissues while TMPRSS2 is expressed in a restricted pattern. High level of NRP1 associates with worse prognosis in multiple cancers, while high level of TMPRSS2 is associated with better survival of Lung Adenocarcinoma (LUAD). Moreover, NRP1 positively correlates with the oncogenic Cancer Associated Fibroblast (CAF), macrophage and endothelial cells infiltration, negatively correlates with infiltration of CD8+ T cell, the tumor killer cell in Lung Squamous cell carcinoma (LUSC). TMPRSS2 shows negative correlation with the oncogenic events in LUAD. RNA-seq data show that NRP1 level is slightly decreased in peripheral blood of ICU admitted COVID-19 patients, unaltered in lung, while TMPRSS2 level is significantly decreased in lung of COVID-19 patients. Our analysis suggests NRP1 as a potential therapeutic target, while sets an alert on targeting TMPRSS2 for treating comorbidity of COVID-19 and lung cancers.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::014869a513a55cb4b5a0cb30ad45f0c1Test
https://doi.org/10.18632/aging.203159Test

7

Expression of CD304/neuropilin‐1 in adult b‐cell lymphoblastic leukemia/lymphoma and its utility for the measurable residual disease assessment

المؤلفون: Sumeet Gujral, Hasmukh Jain, Dhanlaxmi Shetty, Sachin Punatar, Manju Senger, Nilesh Deshpande, Nikhil Patkar, Anumeha Chaturvedi, Sitaram Ghogale, Papagudi Ganesan Subramanian, Karishma Girase, Anant Gokarn, Bhausaheb Bagal, Avinash Bonda, Navin Khattry, Vishesh Dudakia, Gaurav Chatterjee, Prashant Tembhare

المصدر: International Journal of Laboratory Hematology. 43:990-999

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Neoplasm, Residual, Adolescent, Coefficient of variation, Clinical Biochemistry, B-Cell Lymphoblastic Leukemia, 030204 cardiovascular system & hematology, Immunofluorescence, Gastroenterology, Flow cytometry, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Bone Marrow, Precursor B-Cell Lymphoblastic Leukemia-Lymphoma, hemic and lymphatic diseases, Internal medicine, Neuropilin 1, Biomarkers, Tumor, medicine, Humans, Aged, medicine.diagnostic_test, business.industry, Biochemistry (medical), Hematology, General Medicine, Middle Aged, medicine.disease, Neuropilin-1, Lymphoma, body regions, medicine.anatomical_structure, Female, Disease assessment, Bone marrow, business, 030215 immunology

الوصف: INTRODUCTION Many new markers are being evaluated to increase the sensitivity and applicability of multicolor flow cytometry (MFC)-based measurable residual disease (MRD) monitoring. However, most of the studies are limited to childhood B-cell lymphoblastic leukemia/lymphoma (B-ALL), and reports in adult B-ALL are extremely scarce and limited to small cohorts. We studied the expression of CD304/neuropilin-1 in a large cohort of adult B-ALL patients and evaluated its practical utility in MFC-based MRD analysis. METHODS CD304 was studied in blasts from adult B-ALL patients and normal precursor B cells (NPBC) from non-B-ALL bone marrow samples using MFC. CD304 expression intensity and pattern were studied with normalized-mean fluorescent intensity (nMFI) and coefficient of variation of immunofluorescence (CVIF), respectively. MFC-based MRD was performed at end of induction (EOI; day-35), end of consolidation (EOC; day 78-80), and subsequent follow-up (SFU) time points. RESULTS CD304 was positive in 120/214(56.07%) and was significantly associated with BCR-ABL1 fusion (P = .001). EOI-MRD and EOC-MRD were positive in 129/214(60.3%) and 50/81(61.72%), respectively. CD304 was positive in a significant percentage of EOI (48%, 62/129) and EOC (52%, 26/50) MRD-positive B-ALL samples. Its expression was retained, lost, and gained in 73.7%, 26.3%, and 11.3% of EOI-MRD and 85.7%, 14.3%, and none of EOC-MRD samples, respectively. Low-level MRD (

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91d3e2d960c36ca4f02cfd80547890f6Test
https://doi.org/10.1111/ijlh.13456Test

8

Amelioration of neuropilin-1 and RAGE/matrix metalloproteinase-2 pathway-induced renal injury in diabetic rats by rosuvastatin

المؤلفون: Saif A. Khan, M. Salman Khan, Saheem Ahmad, Sultan Alouffi, Rabia Nabi, Sultan Alvi Sahir, Mahvish Khan, Adnan Ahmad

المصدر: Archives of Biological Sciences, Vol 73, Iss 2, Pp 265-278 (2021)

الوصف: Advanced glycation end-products (AGEs) induce the production of reactive oxygen species (ROS) and extra cellular matrix (ECM) degradation via suppression of neuropilin-1 (NRP-1) and interaction with AGE-receptors (RAGE). This study aimed to reveal whether modulation of NRP-1 by rosuvastatin (RT) prevents AGE-induced renal injury via targeting RAGE/matrix metalloproteinase-2 (MMP-2) signaling in diabetic rats. Treatment with RT ameliorated the altered level of markers of glycemic control, renal injury, cholesterol, triglyceride (TG) and hepatic HMG-CoA reductase activity; the level of circulatory carboxymethyl-lysine (CML) and the accumulation of fluorogenic-AGEs in renal tissue was reduced; the expression of renal NRP-1, a checkpoint target, was stimulated; the transcription of RAGE, NF?B-2, TGF-?1 and MMP-2 was suppressed; the circulatory carbonyl content (CC) and paraoxonase-1 (PON-1) activity was ameliorated, and renal histopathological features were attenuated as evidenced by improved glomerular appearance, Bowman?s space and abundant podocytes in kidneys. In conclusion, RT exhibited the potential to counteract diabetes and AGE-induced renal pathologies via stimulation of NRP-1, suppression of RAGE, and of genes responsible for ECM disintegration (MMP-2) and the inflammatory response (NF?B-2).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86b4ce37085f3ff58b71edead7c7f35bTest
https://doi.org/10.2298/abs210316021nTest

9

Neuropilin-1 predicts poor prognosis and promotes tumor metastasis through epithelial-mesenchymal transition in gastric cancer

المؤلفون: Xiaona Chang, Guobin Wang, Nan He, Qianqian Ren, Xiaoming Lu, Haixing Yu, Qianna Jin, Xin Jin

المصدر: Journal of Cancer. 12:3648-3659

مصطلحات موضوعية: 0301 basic medicine, Akt/PKB signaling pathway, business.industry, Cancer, medicine.disease, In vitro, Metastasis, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Neuropilin 1, Cancer research, medicine, Epithelial–mesenchymal transition, business, Gene, PI3K/AKT/mTOR pathway

الوصف: We aimed to determine whether Neuropilin-1 (NRP1) promotes gastric cancer (GC) metastasis by inducing epithelial-mesenchymal transition (EMT), and to clarify its regulatory mechanism. Using the data of GC patients in The Cancer Genome Atlas (TCGA) and Gene Tissue Expression (GTEx) databases, combined with the data of GC patients in our medical center, the effect of NRP1 on the prognosis of GC patients were analyzed. Then, we investigated the role of NRP1 in GC metastasis and its potential mechanism. The level of NRP1 was up-regulated in GC tissues and associated with poor prognosis of GC patients. The expression of NRP1 was closely related to maximum tumor diameter, invasion depth, lymphnode metastasis, distant metastasis, and advanced TNM stage, and was an independent prognostic factor for overall survival (OS) in GC patients. Besides, the results of in vitro indicated that NRP1 could induce EMT to promote the migration and invasion of GC cells by activating PI3K/Akt signaling pathway, and the HGF/c-Met axis was involved in this process. This study determined that NRP1 was a gene that promotes gastric cancer. NRP1 induced EMT to enhance the migration and invasion ability of GC cells by activating PI3K/Akt signaling pathway. NRP1 was an independent prognostic marker for OS in GC patients and expected to be a therapeutic target for GC patients.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066ace8536128fc01a5f573480289ad6Test
https://doi.org/10.7150/jca.52851Test

10

Targeting neuropilin-1 interactions is a promising anti-tumor strategy

المؤلفون: Shao-Dan Liu, Li-Ping Zhong, Jian He, Yong-Xiang Zhao, Li-Shao Guo

المصدر: Chinese Medical Journal
Chinese Medical Journal, Vol 134, Iss 5, Pp 508-517 (2021)

الوصف: Neuropilins (NRP1 and NRP2) are multifunctional receptor proteins that are involved in nerve, blood vessel, and tumor development. NRP1 was first found to be expressed in neurons, but subsequent studies have demonstrated its surface expression in cells from the endothelium and lymph nodes. NRP1 has been demonstrated to be involved in the occurrence and development of a variety of cancers. NRP1 interacts with various cytokines, such as vascular endothelial growth factor family and its receptor and transforming growth factor β1 and its receptor, to affect tumor angiogenesis, tumor proliferation, and migration. In addition, NRP1+ regulatory T cells (Tregs) play an inhibitory role in tumor immunity. High numbers of NRP1+ Tregs were associated with cancer prognosis. Targeting NRP1 has shown promise, and antagonists against NRP1 have had therapeutic efficacy in preliminary clinical studies. NRP1 treatment modalities using nanomaterials, targeted drugs, oncolytic viruses, and radio-chemotherapy have gradually been developed. Hence, we reviewed the use of NRP1 in the context of tumorigenesis, progression, and treatment.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bea30c1d8ac01bd99f422835af3a89dTest
https://doi.org/10.1097/cm9.0000000000001200Test

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