نتائج البحث - "Lyme Neuroborreliosis"

1

Acute facial nerve palsy in children in a Lyme disease–endemic area in the Netherlands

المؤلفون: R. A. Bruinsma, C. A. Smulders, T.P. Zomer, Joppe W. Hovius, E. A. Cats, B.C. van Hees, Yolande M Vermeeren, B. van Kooten, M Boele van Hensbroek

المساهمون: Global Health, General Paediatrics, Paediatric Infectious Diseases / Rheumatology / Immunology, AII - Infectious diseases, APH - Global Health, Center of Experimental and Molecular Medicine, Infectious diseases

المصدر: European journal of clinical microbiology & infectious diseases, 40(11), 2455-2458. Springer Verlag

الوصف: We assessed the prevalence of Lyme neuroborreliosis in children with acute facial nerve palsy in a Lyme-endemic region and patient characteristics associated with this. All children visiting one of three participating hospitals between January 2010 and December 2016 were included in the study. Of 104 children referred to the hospital with facial nerve palsy, 43% had Lyme neuroborreliosis and 57% idiopathic facial palsy. Characteristics significantly associated with Lyme neuroborreliosis were headache (55% versus 18%), meningeal irritation (21% versus 5%), presentation in summer months (69% versus 37%), and a previous tick bite (33% versus 7%).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d7c033497941b1b61e808edc7188882Test
http://www.scopus.com/inward/record.url?scp=85105864522&partnerID=8YFLogxKTest

2

Lyme neuroborreliosis with encephalitis; a systematic literature review and a Scandinavian cohort study

المؤلفون: Else Quist-Paulsen, Daniel Bremell, Randi Eikeland, Sigurdur Skarphedinsson, Anne-Marit Solheim, Fredrikke Christie Knudtzen, Isik Somuncu Johansen

المصدر: Knudtzen, F C, Eikeland, R, Bremell, D, Quist-Paulsen, E, Johansen, I S, Solheim, A M & Skarphédinsson, S 2022, ' Lyme neuroborreliosis with encephalitis; a systematic literature review and a Scandinavian cohort study ', Clinical Microbiology and Infection, vol. 28, no. 5, pp. 649-656 . https://doi.org/10.1016/j.cmi.2021.11.001Test
Clinical Microbiology and Infection (CMI)

الوصف: Background Lyme neuroborreliosis (LNB) presenting with encephalitis is rare and scarcely described. Objectives To describe the available literature on LNB encephalitis and to characterize this patient group through a Scandinavian retrospective cohort study. Data sources Medline, Embase, Scopus, Cochrane library. Study eligibility criteria There was no discrimination on study type, time of publication or language. Participants Review: All articles with definite LNB and confirmed/possible encephalitis. Cohort: LNB cohorts from Denmark, Sweden and Norway 1990–2019 were screened for patients with encephalitis. Methods Review: Adhering to PRISMA guidelines; two authors extracted reviews and assessed quality of studies. Cohort: Data on demography, symptoms, cerebrospinal fluid findings, differential diagnostic examinations, treatment, residual symptoms, 1-year mortality were registered. Results Review: 2330 articles screened on title/abstract, 281 full texts, yielding 42 articles (case reports/series or cohort studies), including 45 patients from 18 countries spanning 35 years. Altered mental status ranged from personality changes and confusion to unconsciousness. Common focal symptoms were hemiparesis, ataxia and dysarthria; seven patients had seizures. Median time from symptom onset to hospital was 2 weeks (IQR 2–90 days). Of 38 patients with available follow-up after median 12 months (IQR 5–13), 32 had fully or partially recovered, two had died. Cohort: Thirty-five patients (median age 67 years, IQR 48–76) were included. The encephalitis prevalence was 3.3% (95% CI 2.2–4.4%) among 1019 screened LNB patients. Frequent encephalitis symptoms were confusion, personality changes, aphasia, ataxia. EEGs and neuroimaging showed encephalitis in 93.8% and 20.6%, respectively. Median delay from symptom onset to hospital was 14 days (IQR 7–34), with further 7 days (IQR 3–34) delay until targeted therapy. At follow-up (median 298 days post-treatment; IQR 113–389), 65.6% had residual symptoms. None had died. Conclusions This study shows that encephalitis is an uncommon, but likely overlooked clinical manifestation of LNB. As the high frequency of residual symptoms may be related to prolonged treatment delay, prompt LNB testing of patients with encephalitis in Borrelia burgdorferi-endemic areas should be considered. publishedVersion

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9c0c8362e62c16487813b16155dd31cTest
https://findresearcher.sdu.dk:8443/ws/files/202222974/1_s2.0_S1198743X21006285_main.pdfTest

3

Approach to Facial Weakness

المؤلفون: Barney J. Stern, Yujie Wang, Camilo Diaz Cruz

المصدر: Seminars in Neurology. 41:673-685

مصطلحات موضوعية: Mastoiditis, medicine.medical_specialty, Palsy, business.industry, Facial Paralysis, Herpes Zoster Oticus, Facial weakness, medicine.disease, Botulinum toxin, Facial nerve, Dermatology, Neurology, Lyme Neuroborreliosis, Synkinesis, Adrenal Cortex Hormones, Bell Palsy, medicine, Humans, Neurology (clinical), medicine.symptom, business, medicine.drug

الوصف: Facial palsy is a common neurologic concern and is the most common cranial neuropathy. The facial nerve contains motor, parasympathetic, and special sensory functions. The most common form of facial palsy is idiopathic (Bell's palsy). A classic presentation requires no further diagnostic measures, and generally improves with a course of corticosteroid and antiviral therapy. If the presentation is atypical, or concerning features are present, additional studies such as brain imaging and cerebrospinal fluid analysis may be indicated. Many conditions may present with facial weakness, either in isolation or with other neurologic signs (e.g., multiple cranial neuropathies). The most important ones to recognize include infections (Ramsay-Hunt syndrome associated with herpes zoster oticus, Lyme neuroborreliosis, and complications of otitis media and mastoiditis), inflammatory (demyelination, sarcoidosis, Miller–Fisher variant of Guillain–Barré syndrome), and neoplastic. No matter the cause, individuals may be at risk for corneal injury, and, if so, should have appropriate eye protection. Synkinesis may be a bothersome residual phenomenon in some individuals, but it has a variety of treatment options including neuromuscular re-education and rehabilitation, botulinum toxin chemodenervation, and surgical intervention.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8a423b853bd4891d55560dfb2ebaefTest
https://doi.org/10.1055/s-0041-1726358Test

4

Lyme neuroborreliosis in Swedish children—PCR as a complementary diagnostic method for detection of Borrelia burgdorferi sensu lato in cerebrospinal fluid

المؤلفون: Barbro H. Skogman, Stephanie Atallah, Katarina Ornstein, Per-Eric Lindgren, Peter Wilhelmsson, Ann-Cathrine Petersson

المصدر: European Journal of Clinical Microbiology & Infectious Diseases

مصطلحات موضوعية: Male, Microbiology (medical), Infectious Medicine, medicine.medical_specialty, Adolescent, Lyme neuroborreliosis, Infektionsmedicin, Polymerase Chain Reaction, Sensitivity and Specificity, law.invention, Medical microbiology, Cerebrospinal fluid, Borrelia burgdorferi Group, law, RNA, Ribosomal, 16S, Borrelia, Diagnosis, medicine, Humans, Borrelia burgdorferi, Child, Children, Polymerase chain reaction, Retrospective Studies, Sweden, biology, business.industry, Infant, PCR, Diagnostic test, General Medicine, bacterial infections and mycoses, biology.organism_classification, Virology, LYME, RNA, Bacterial, Infectious Diseases, Lyme Neuroborreliosis, Child, Preschool, biology.protein, Original Article, Female, Antibody, business

الوصف: The aim of this study was to evaluate polymerase chain reaction (PCR) as a diagnostic method for the detection of Borrelia burgdorferi s.l. in CSF of Swedish children with LNB. This study was performed retrospectively on CSF and serum samples collected from children evaluated for LNB (n = 233) and controls with other specific neurological disorders (n = 59) in a Swedish Lyme endemic area. For anti-Borrelia antibody index, the IDEIA Lyme Neuroborreliosis kit (Oxoid) was used. Two in-house real-time PCR assays targeting the 16S rRNA gene were evaluated (TaqMan® and LUX™). Among patients classified as LNB cases (n = 102), five children (5%) were Borrelia PCR-positive in CSF with the TaqMan® assay. In the Non-LNB group (n = 131), one patient was Borrelia PCR positive with the TaqMan® assay. Among controls (n = 59), all CSF samples were PCR negative. When amplifying and sequencing ospA, we found B. garinii (n = 2), B. afzelii (n = 2), B. bavariensis (n = 1), and one untypable (n = 1). With the LUX™ technology, all CSF samples were PCR negative. The TaqMan® assay could detect only few cases (n = 6) of B. burgdorferi s.l. in CSF among children with LNB and the sensitivity was very low (5%). However, using larger CSF volumes and centrifugation of samples, the PCR technique could still be useful as a complementary diagnostic method when evaluating LNB. Furthermore, detection of spirochete DNA in clinical matrices, including CSF, is the method of choice for studying epidemiological aspects of LNB, a tick-borne emerging disease.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33a7e330ed02c98fe26f3fd31e41b62bTest
https://doi.org/10.1007/s10096-020-04129-7Test

5

Surveillance and epidemiology of Lyme borreliosis in the Czech Republic in 2018 and 2019

المؤلفون: Kateřina Kybicová, Marek Malý, Jan Kynčl, Hana Orlíková

المصدر: Biologia. 77:1651-1660

الوصف: Lyme borreliosis (LB), the most prevalent vector-borne disease in Europe, is caused by Borrelia burgdorferi sensu lato complex species and transmitted by the tick Ixodes ricinus. The Czech Republic is an endemic country for LB. The disease affects the skin, neurological, musculoskeletal, cardiac or ocular tissue, and the most frequent clinical manifestations are erythema migrans and Lyme neuroborreliosis. In 2018, the EU case definition of Lyme neuroborreliosis was published, and neuroborreliosis has become reportable to the European Surveillance System. In this paper, we describe the LB surveillance system and reporting of human cases in the Czech Republic. Epidemiological characteristics of Lyme borreliosis are presented for 2018 and 2019. Gaps in and limitations of the existing national LB surveillance system were identified with regard to the reporting of neuroborreliosis in accordance with the EU case definition. In the Czech Republic, LB surveillance is nationwide, comprehensive, and mandatory. Case based data on all clinical manifestations of incident LB are reported to the electronic Information System of Infectious Diseases (ISIN). In 2018 and 2019, 4724 and 4102 LB cases, i.e., 44.5 and 38.4 cases per 100,000 population, were reported to ISIN, respectively. Overall, 46.3 % of cases were male and 53.7 % were female. The highest morbidity was observed in adults 50–75 and children 5–9 years old. The most affected regions were Vysocina and Olomoucký. Nine districts recorded more than 100 cases per 100,000 population. Erythema migrans appeared in 3173 (67.2 %) and 2756 (67.2 %) patients in 2018 and 2019, respectively. In 2018, 596 (12.6 %) Lyme neuroborreliosis cases were diagnosed only on the basis of clinical manifestations while in 2019, a total of 567 (13.8 %) cases of neuroborreliosis fully meeting the EU case definition were reported. The Czech Republic is an endemic country for LB with some hotspots, similar to some central, northern and north-eastern European countries. To implement the EU neuroborreliosis surveillance in the Czech Republic, ISIN technical update, addition of required variables to it, preparation of legislation update, and training of health professionals were needed.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b7f9213ea3413baeb330b59eafdadfc1Test
https://doi.org/10.1007/s11756-021-00868-wTest

6

Atypical bacterial infections of the central nervous system transmitted by ticks: An unknown threat

المؤلفون: J. Azcona Saenz, C.A. Salas Venero, E. Marco de Lucas, D. Herrán de la Gala, A.M. Arnáiz García

المصدر: Radiología (English Edition). 63:425-435

الوصف: Infections of the central nervous system caused by atypical bacteria are becoming more common. Borrelia burgdorferi and Rickettsia conorii are microorganisms transmitted by ticks; infection with these bacteria result in a wide spectrum of manifestations on imaging. In areas where these tick-borne microorganisms are endemic, including Spain, these infections must be included in the differential diagnosis of patients with a variety of systemic and neurologic symptoms. The clinical presentation of these infections is nonspecific, and CT is normally the initial imaging technique, although MRI is more sensitive to early changes. On MRI, these infections can manifest as small lesions in the deep supratentorial white matter that are hyperintense on T2-weighted/FLAIR sequences. It is fundamental to know the imaging characteristics of the different atypical bacterial infections and their differential diagnoses. Good history taking combined with complementary tests (blood tests and CSF analysis) and the neuroimaging findings can help reach the right diagnosis and enable appropriate treatment, thereby preventing possible neurological sequelae.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f017f1c0a6741ec3f50e71327efbef4Test
https://doi.org/10.1016/j.rxeng.2021.07.002Test

7

Case 292: Lyme Neuroborreliosis

المؤلفون: Konstantinos A A Douglas, Katherine L. Reinshagen, Bart K Chwalisz, Vivian Paraskevi Douglas

المصدر: Radiology. 300:484-488

الوصف: History A 24-year-old right-handed woman presented to a neuro-ophthalmology clinic in Massachusetts in the summer with acute binocular diplopia when looking down and to the left, which started about 1 month earlier. Her medical history was notable for Raynaud syndrome, recurrent streptococcal pharyngitis, and an allergy to amoxicillin. Three days prior to developing diplopia, she presented to an outside emergency department due to fever, chills, and back pain. She received ciprofloxacin for presumed urinary tract infection based on urinalysis, which demonstrated few bacteria and was negative for leukocyte esterase, nitrites, and white blood cells. She then presented again to an outside emergency department for diplopia evaluation. Initial MRI and MR angiography of the brain at that time did not demonstrate any relevant findings, and the patient was referred to our department for neuro-ophthalmic evaluation, where she was seen 4 weeks later. Neuro-ophthalmic examination revealed 20/20 visual acuity in both eyes, and a right hypertropia in left gaze, downgaze and right head tilt, with right eye excyclotorsion. There were no ocular signs of myasthenia gravis or thyroid eye disease, nor did the patient report ocular or systemic symptoms. She denied recent travel. High-spatial-resolution MRI of the brain and orbit were performed.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f08a47c6571c3c2aa485a618c8161fbTest
https://doi.org/10.1148/radiol.2021201715Test

8

CXCL13 in laboratory diagnosis of Lyme neuroborreliosis-the performance of the recomBead and ReaScan CXCL13 assays in human cerebrospinal fluid samples

المؤلفون: Gärda Andersson, Paula Gyllemark, Oskar Ekelund, Sofie Haglund, Martin Sundqvist, Malin Lager, Anna J. Henningsson

المصدر: European Journal of Clinical Microbiology & Infectious Diseases

الوصف: The chemokine CXCL13 is used as complement to serology in the diagnostics of Lyme neuroborreliosis (LNB). We evaluated and compared the semi-quantitative, cassette-based ReaScan CXCL13 assay with the quantitative recomBead CXCL13 assay using a collection of 209 cerebrospinal fluid samples. The categorical agreement between results interpreted as negative, grey zone, and positive by the two methods was 87%. The diagnostic sensitivity was higher using the recomBead assay, whereas specificity was higher using ReaScan. Few manual steps, and a short turn-around time with no batching of samples makes the ReaScan CXCL13 assay an attractive complement to serology in the diagnostics of LNB. Funding Agencies|European Union through the European Regional Development FundEuropean Commission; Interreg North Sea Region Programme [J-No: 38-2-7-19]

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::51944148eeea9ee5f1f452ffd4585892Test
http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-180499Test

9

Clinical manifestations and long‐term outcome of early Lyme neuroborreliosis according to the European Federation of Neurological Societies diagnostic criteria (definite versus possible) in central Europe. A retrospective cohort study

المؤلفون: Tjaša Cerar Kišek, Stefan Collinet-Adler, Fajko F. Bajrović, Eva Ružić-Sabljić, Anja Lah, Daša Stupica, Rok Blagus, Eva Levstek

المصدر: European Journal of Neurology. 28:3155-3166

مصطلحات موضوعية: Adult, Doxycycline, Pediatrics, medicine.medical_specialty, business.industry, Retrospective cohort study, Disease, Bannwarth syndrome, medicine.disease, Anti-Bacterial Agents, Europe, Neurology, Lyme Neuroborreliosis, Ceftriaxone, Etiology, Humans, Medicine, Neurology (clinical), business, Meningitis, Retrospective Studies, medicine.drug

الوصف: BACKGROUND AND PURPOSE The characteristics and long-term outcome of Lyme neuroborreliosis (LNB) according to diagnostic certainty (definite vs. possible) are incompletely understood. METHODS In this retrospective cohort study of adults with definite or possible LNB, clinical and microbiological characteristics and long-term outcome over 12 months were evaluated at a single medical center. Severity of acute disease and long-term outcome were assessed using a composite clinical score encompassing clinical findings and symptoms and by the probability of incomplete recovery. RESULTS Amongst 311 adult patients enrolled from 2008 to 2017, 139 (44.7%) had definite LNB and 172 (55.3%) had possible LNB. The most frequent LNB manifestation was cranial neuropathy with or without meningitis (53.4%). Patients with definite LNB more often had Bannwarth syndrome (53.2% vs. 18.6%), more severe disease (6 points vs. 4 points), longer pre-treatment duration (median 21 days vs. 13.5 days), higher cerebrospinal fluid pleocytosis (median 139 × 106 /L vs. 11 × 106 /L) and higher rate of Borrelia seropositivity (84.2% vs. 68.6%) than those with possible LNB. Ceftriaxone was prescribed more often than oral doxycycline in definite LNB than in possible LNB (96.4% vs. 65.7%). Unfavorable outcomes decreased during follow-up, being higher in patients with more severe disease at enrollment and in those with possible LNB, but were not associated with antibiotic therapy. CONCLUSIONS Early LNB, most often presenting as cranial neuropathy, was definitively diagnosed in less than half of cases. A better diagnostic approach is needed to confirm borrelial etiology. Ceftriaxone was not superior to doxycycline in the treatment of early LNB, regardless of diagnostic certainty. In this retrospective cohort study of 311 adults with Lyme neuroborreliosis (LNB), allocated according to diagnostic certainty, early LNB was definitively diagnosed in less than half of cases and the most frequent LNB manifestation was cranial neuropathy with or without meningitis. Patients with definite LNB more often had Bannwarth syndrome, more severe disease, longer pre-treatment duration, higher cerebrospinal fluid pleocytosis and higher rate of Borrelia seropositivity than those with possible LNB. A better diagnostic approach is needed to confirm borrelial etiology. Ceftriaxone was not superior to doxycycline in the treatment of early LNB, regardless of diagnostic certainty.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbdae573b930da5a870d8d07df9eb075Test
https://doi.org/10.1111/ene.14962Test

10

Lyme-Borreliose und Neuroborreliose – Was ist neu?

المؤلفون: Volker Fingerle, Rick Dersch

المصدر: DMW - Deutsche Medizinische Wochenschrift. 146:728-732

مصطلحات موضوعية: Gynecology, medicine.medical_specialty, Lyme disease, Lyme Neuroborreliosis, Lyme borreliosis, business.industry, medicine, General Medicine, medicine.disease, business

الوصف: Was ist neu? Diagnostik Zellbasierte Verfahren (z. B. LTT, ELISPOT) sollten nicht für die Diagnosestellung einer Borreliose verwendet werden. Therapie Eine aktuelle randomisiert-kontrollierte Studie hat bestätigt, dass Doxycyclin- und Betalaktam-Antibiotika gleichwertig eingesetzt werden können. Es gibt keine statistisch signifikanten Unterschiede hinsichtlich neurologischer Symptome nach Therapie und Nebenwirkungen. Dementsprechend wird in der S3-Leitlinie Neuroborreliose kein Präparat bevorzugt empfohlen. Prognose Mehreren Studien mit Patienten mit antibiotisch behandelter Neuroborreliose zeigen im Langzeitverlauf keine erhöhte Rate an Fatigue im Vergleich zu gesunden Kontrollpersonen. Ebenso findet sich für Lebensqualität, Depression und Kognition kein Unterschied zwischen Patienten mit Neuroborreliose nach Antibiotikatherapie und gesunden Kontrollpersonen im Langzeitverlauf. Prophylaxe Eine prophylaktische Antibiotikagabe nach Zeckenstich wird derzeit in Deutschland nicht empfohlen.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f8165f566ba7e74f331befb3c1e70a53Test
https://doi.org/10.1055/a-1265-4397Test

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