Harnessing the Endogenous Plasticity of Pancreatic Islets: A Feasible Regenerative Medicine Therapy for Diabetes?
| العنوان: | Harnessing the Endogenous Plasticity of Pancreatic Islets: A Feasible Regenerative Medicine Therapy for Diabetes? |
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| المؤلفون: | Benoit R. Gauthier, Petra I. Lorenzo, Nadia Cobo-Vuilleumier, Livia López-Noriega, Eugenia Martín-Vázquez |
| المساهمون: | Junta de Andalucía, Ministerio de Economía y Competitividad (España), Instituto de Salud Carlos III, European Commission, Juvenile Diabetes Research Foundation, Fundación Vencer el Cancer, Asociación Lucha y Sonríe por la Vida (España), Fundación DiabetesCERO, Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España) |
| المصدر: | International Journal of Molecular Sciences International Journal of Molecular Sciences, Vol 22, Iss 4239, p 4239 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, LRH-1/NR52A, transdifferentiation, medicine.medical_treatment, Review, Bioinformatics, Regenerative Medicine, 0302 clinical medicine, Insulin-Secreting Cells, Glucose homeostasis, Insulin, Biology (General), Spectroscopy, geography.geographical_feature_category, diabetes, Transdifferentiation, β-cell heterogeneity, General Medicine, Islet, Computer Science Applications, Chemistry, medicine.anatomical_structure, QH301-705.5, 030209 endocrinology & metabolism, Catalysis, Inorganic Chemistry, 03 medical and health sciences, Islets of Langerhans, Diabetes mellitus, medicine, Animals, Humans, Physical and Theoretical Chemistry, Molecular Biology, QD1-999, geography, PAX4, business.industry, Pancreatic islets, Regeneration (biology), Organic Chemistry, medicine.disease, redifferentiation, 030104 developmental biology, Diabetes Mellitus, Type 1, regeneration, Cell Transdifferentiation, HMG20A, business, single-cell transcriptomics |
| الوصف: | Diabetes is a chronic metabolic disease caused by an absolute or relative deficiency in functional pancreatic β‐cells that leads to defective control of blood glucose. Current treatments for diabetes, despite their great beneficial effects on clinical symptoms, are not curative treatments, leading to a chronic dependence on insulin throughout life that does not prevent the secondary complications associated with diabetes. The overwhelming increase in DM incidence has led to a search for novel antidiabetic therapies aiming at the regeneration of the lost functional β‐cells to allow the re‐establishment of the endogenous glucose homeostasis. Here we review several aspects that must be considered for the development of novel and successful regenerative therapies for diabetes: first, the need to maintain the heterogeneity of islet β‐cells with several subpopulations of β‐cells characterized by different transcriptomic profiles correlating with differences in functionality and in resistance/behavior under stress conditions; second, the existence of an intrinsic islet plasticity that allows stimulus‐mediated transcriptome alterations that trigger the transdifferentiation of islet non‐β‐cells into β‐cells; and finally, the possibility of using agents that promote a fully functional/mature β‐cell phenotype to reduce and reverse the process of dedifferentiation of β‐cells during diabetes. Authors were/are funded by grants from Consejería de Salud, Fundación Pública Andaluza Progreso y Salud, Junta de Andalucía (PI-0727-2010, December 2010 to B.R.G., PI-0085-2013, December 2013 to P.I.L., and PI-0001-2020, December 2020 to B.R.G. and P.I.L.); Consejería de Economía, Innovación y Ciencia, Junta de Andalucía (P10-CTS-6359 to B.R.G.); Ministerio de Economía y Competitividad, Instituto de Salud Carlos III, cofunded by Fondos FEDER (PI10/00871, January 2011 and PI13/00593, January 2014 to B.R.G.); Ministerio de Economía y Competitividad, Plan Nacional (BFU2017-83588-P, January 2018 to B.R.G. and PRE2018-084907, January 2018 to E.M.-V.); Juvenile Diabetes Research Foundation JDRF (17-2013-372, August 2013 and 2-SRA-2019-837-S-B, August 2019 to B.R.G:); and Fundacion Vencer el Cancer (to B.R.G.). Special thanks to ALUSVI (Asociación Lucha y Sonríe por la Vida, Pilas), a local Andalusian association, and the Fundacion DiabetesCero for their unconditional financial support. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::965e230b6623cb1b4291d5f1551249feTest http://europepmc.org/articles/PMC8073058Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....965e230b6623cb1b4291d5f1551249fe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14220067 |
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