نتائج البحث - "Jan W. Eriksson"

1

Metformin as an anti-inflammatory agent: a short review

المؤلفون: Jan W. Eriksson, Robin Kristófi

المصدر: Journal of Endocrinology. 251:R11-R22

الوصف: Metformin is a biguanide drug widely used as the initial treatment of type 2 diabetes. Despite its widespread use, its precise mechanisms of action remain incompletely characterised. Its effect in lowering blood glucose is largely related to the suppression of gluconeogenesis in the liver, which is probably accomplished by partial inhibition of the mitochondrial respiratory chain complex 1 with a subsequent increase in intracellular AMP levels and activation of AMP kinase. Several local and systemic anti-inflammatory effects of metformin have been described. Many of these effects seem to be mediated by AMP kinase activation and downstream effects inhibiting mTOR and NF-κB pro-inflammatory signalling cascades. However, there are also studies describing actions independent of AMP kinase action. In this review, we summarise the currently known mechanisms of metformin on inflammatory pathways and the clinical evidence underpinning the use of metformin as a potential anti-inflammatory drug.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b47f77aba0efa329b2e4456cf0d145b4Test
https://doi.org/10.1530/joe-21-0194Test

2

Tissue-specific glucose partitioning and fat content in prediabetes and type 2 diabetes: whole-body PET/MRI during hyperinsulinemia

المؤلفون: Maria J. Pereira, Martin Lundqvist, Mark Lubberink, Robin Visvanathar, Stanko Skrtic, Robin Strand, Jan W. Eriksson, Petros Katsogiannos, Håkan Ahlström, Simon Ekström, Joel Kullberg

المصدر: European Journal of Endocrinology. 184:879-889

مصطلحات موضوعية: Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Glucose uptake, 030209 endocrinology & metabolism, Type 2 diabetes, Carbohydrate metabolism, Multimodal Imaging, Prediabetic State, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Insulin resistance, Hyperinsulinism, Internal medicine, Diabetes mellitus, Hyperinsulinemia, Humans, Medicine, Prediabetes, Muscle, Skeletal, Aged, business.industry, General Medicine, Middle Aged, Glucose clamp technique, medicine.disease, Magnetic Resonance Imaging, Glucose, Adipose Tissue, Diabetes Mellitus, Type 2, Positron-Emission Tomography, 030220 oncology & carcinogenesis, Glucose Clamp Technique, Female, Insulin Resistance, business

الوصف: Objective To obtain direct quantifications of glucose turnover, volumes and fat content of several tissues in the development of type 2 diabetes (T2D) using a novel integrated approach for whole-body imaging. Design and methods Hyperinsulinemic–euglycemic clamps and simultaneous whole-body integrated [18F]FDG-PET/MRI with automated analyses were performed in control (n = 12), prediabetes (n = 16) and T2D (n = 13) subjects matched for age, sex and BMI. Results Whole-body glucose uptake (Rd) was reduced by approximately 25% in T2D vs control subjects, and partitioning to brain was increased from 3.8% of total Rd in controls to 7.1% in T2D. In liver, subcutaneous AT, thigh muscle, total tissue glucose metabolic rates (MRglu) and their % of total Rd were reduced in T2D compared to control subjects. The prediabetes group had intermediate findings. Total MRglu in heart, visceral AT, gluteus and calf muscle was similar across groups. Whole-body insulin sensitivity assessed as glucose infusion rate correlated with liver MRglu but inversely with brain MRglu. Liver fat content correlated with MRglu in brain but inversely with MRglu in other tissues. Calf muscle fat was inversely associated with MRglu only in the same muscle group. Conclusions This integrated imaging approach provides detailed quantification of tissue-specific glucose metabolism. During T2D development, insulin-stimulated glucose disposal is impaired and increasingly shifted away from muscle, liver and fat toward the brain. Altered glucose handling in the brain and liver fat accumulation may aggravate insulin resistance in several organs.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bde5cf34d3ff204657a9980524d43761Test
https://doi.org/10.1530/eje-20-1359Test

3

Quality of life after gastric bypass surgery in patients with type 2 diabetes: patients’ experiences during 2 years of follow-up

المؤلفون: Janeth Leksell, Andreas Rosenblad, Jan W. Eriksson, Petros Katsogiannos, Magnus Sundbom, Eva Randell

المصدر: Diabetology & Metabolic Syndrome, Vol 12, Iss 1, Pp 1-8 (2020)
Diabetology & Metabolic Syndrome

مصطلحات موضوعية: Quality of life, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, 030209 endocrinology & metabolism, Type 2 diabetes, Endocrinology and Diabetes, medicine.disease_cause, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, RYGB, Weight loss, law, Diabetes mellitus, Health Sciences, Internal Medicine, medicine, 030212 general & internal medicine, lcsh:RC620-627, Gastric bypass surgery, business.industry, Research, Kirurgi, Hälsovetenskaper, medicine.disease, Obesity, lcsh:Nutritional diseases. Deficiency diseases, Endokrinologi och diabetes, Physical therapy, Surgery, medicine.symptom, business, Body mass index

الوصف: Background To examine the effects of gastric bypass surgery on health-related quality of life (HRQoL) in obese patients with type 2 diabetes, and to investigate their experiences of life adjustments using quantitative and qualitative methods. Methods Thirteen patients with type 2 diabetes and obesity, (body mass index, BMI > 30 kg/m2), participating in a randomized clinical trial, completed this sub-study. HRQoL was evaluated before, and at 6 months and 2 years after gastric bypass surgery, using the RAND- 36-item health survey. At 2 years, interviews for in-depth analysis of HRQoL changes were performed. Results Significant improvement was observed from baseline to 6 months for 2 of the eight health concepts, general health, and emotional well-being. At 2 years, improvements were also seen in physical functioning, energy/fatigue, as well as sustained improvements in general health and emotional well-being. Multiple regression analyses showed mostly non-significant associations between the magnitude of decrease in weight, BMI, and HbA1c during follow-up and improvement in HRQoL. The analyses from qualitative interviews supported a common latent theme “Finding a balance between the experience of the new body weight and self-confidence”. Conclusions The improved HRQoL after gastric bypass surgery in obese patients with type 2 diabetes was not explained specifically by the magnitude of weight loss, but rather by the participants achieving a state of union between body and consciousness. Trial registration ClinicalTrials.gov Identifier NCT02729246. Date of registration 6 April 2016 – Retrospectively registered https://clinicaltrials.gov/ct2/show/NCT02729246?term=bariglykos&draw=2&rank=1Test

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79eef0960e571676755e47f5d2be0e42Test
http://link.springer.com/article/10.1186/s13098-020-00597-1Test

4

Integration of whole-body [18F]FDG PET/MRI with non-targeted metabolomics can provide new insights on tissue-specific insulin resistance in type 2 diabetes

المؤلفون: Ulf Risérus, Chanchal Kumar, Maria J. Pereira, Claes Wadelius, Klev Diamanti, Gang Pan, Håkan Ahlström, Joel Kullberg, Jan W. Eriksson, Marco Cavalli, Stanko Skrtic, Robin Visvanathar, Jan Komorowski

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020)

الوصف: Alteration of various metabolites has been linked to type 2 diabetes (T2D) and insulin resistance. However, identifying significant associations between metabolites and tissue-specific phenotypes requires a multi-omics approach. In a cohort of 42 subjects with different levels of glucose tolerance (normal, prediabetes and T2D) matched for age and body mass index, we calculated associations between parameters of whole-body positron emission tomography (PET)/magnetic resonance imaging (MRI) during hyperinsulinemic euglycemic clamp and non-targeted metabolomics profiling for subcutaneous adipose tissue (SAT) and plasma. Plasma metabolomics profiling revealed that hepatic fat content was positively associated with tyrosine, and negatively associated with lysoPC(P-16:0). Visceral adipose tissue (VAT) and SAT insulin sensitivity (Ki), were positively associated with several lysophospholipids, while the opposite applied to branched-chain amino acids. The adipose tissue metabolomics revealed a positive association between non-esterified fatty acids and, VAT and liver Ki. Bile acids and carnitines in adipose tissue were inversely associated with VAT Ki. Furthermore, we detected several metabolites that were significantly higher in T2D than normal/prediabetes. In this study we present novel associations between several metabolites from SAT and plasma with the fat fraction, volume and insulin sensitivity of various tissues throughout the body, demonstrating the benefit of an integrative multi-omics approach.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73adb9b2299fd38e129a8b410ece2e0dTest
http://link.springer.com/article/10.1038/s41598-020-64524-0Test

5

Comparison of four non-alcoholic fatty liver disease detection scores in a Caucasian population

المؤلفون: Lars Johansson, Anders Larsson, Joel Kullberg, Jan W. Eriksson, Jan Oscarsson, Lars Lind, Håkan Ahlström, Ulf Risérus

المصدر: World Journal of Hepatology

الوصف: Background Non-alcoholic fatty liver disease (NAFLD) is a common disorder, with an estimated prevalence ranging from 20% to 35% in the general population. Several scores based on easily measurable biochemical and clinical parameters, including the fatty liver index (FLI), hepatic steatosis index (HSI), lipid accumulation product (LAP), and NAFLD liver fat score (LFS), have been developed for the detection of NAFLD. However, comparative information regarding the efficacy of these scores for predicting NAFLD in population-based samples comprising normal and high-risk individuals is lacking. Aim To evaluate four NAFLD detection scores in two samples with different NAFLD risks. Methods NAFLD screening was performed in a population-based sample of 50-year-old individuals in Uppsala, Sweden [n = 310; Prospective investigation of obesity, energy and metabolism (POEM) study] and a high-risk population comprising patients with a body mass index > 25 kg/m2 and either high plasma triglycerides (≥ 1.7 mmol/L) or type 2 diabetes (n = 310; EFFECT studies). NAFLD was defined as liver fat > 5.5% using magnetic resonance imaging-proton density fat fraction. FLI, HSI, LAP, and NAFLD LFS were assessed. A logistic regression model was used to evaluate the effectiveness of the different scores. Results The prevalence of NAFLD was 23% in POEM. FLI showed the highest receiver operating characteristic area under the curve (ROC AUC; 0.82) and was significantly better than the LAP score (P = 0.005 vs LAP, P = 0.08 vs LFS, P = 0.12 vs HSI) for detection of NAFLD. The other three indices performed equally in POEM (0.77-0.78). The prevalence of NAFLD was 74% in EFFECT; LFS performed best (ROC AUC 0.80) in this sample. The ROC AUC for LFS (0.80) was significantly higher than that for FLI (P = 0.0019) and LAP (P = 0.0022), but not HSI (P = 0.11). We performed a sensitivity analysis with stratification for the two high-risk subgroups (patients with diabetes or hypertriglyceridemia) from the EFFECT studies. LAP performed best in patients with hypertriglyceridemia. No major differences were observed between the other scores. Conclusion The four investigated NAFLD scores performed differently in the populationbased vs high-risk setting. FLI was preferable in the population-based setting, while LFS performed best in the high-risk setting.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6c586d71ec2622f2a2848190e0102a0Test
https://doi.org/10.4254/wjh.v12.i4.149Test

6

Validation of automated whole-body analysis of metabolic and morphological parameters from an integrated FDG-PET/MRI acquisition

المؤلفون: Håkan Ahlström, Simon Ekström, Robin Visvanathar, Maria J. Pereira, Stanko Skrtic, Filip Malmberg, Joel Kullberg, Jan W. Eriksson, Emil Johansson, Priscilla Guglielmo, B. C. L. Carlsson, Robin Strand

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020)
Scientific Reports

مصطلحات موضوعية: Male, Future studies, Biochemical Phenomena, Fat content, Image registration, lcsh:Medicine, 030209 endocrinology & metabolism, Group comparison, Multimodal Imaging, Article, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Fluorodeoxyglucose F18, Image Interpretation, Computer-Assisted, Image Processing, Computer-Assisted, Humans, Medicine, Whole Body Imaging, Segmentation, lcsh:Science, Aged, Multidisciplinary, Molecular medicine, business.industry, Diabetes, lcsh:R, Brain, Reproducibility of Results, Image segmentation, Middle Aged, Magnetic Resonance Imaging, Liver, Positron-Emission Tomography, Female, lcsh:Q, Radiologi och bildbehandling, Tomography, X-Ray Computed, Whole body, business, Nuclear medicine, Algorithms, Tissue volume, Radiology, Nuclear Medicine and Medical Imaging

الوصف: Automated quantification of tissue morphology and tracer uptake in PET/MR images could streamline the analysis compared to traditional manual methods. To validate a single atlas image segmentation approach for automated assessment of tissue volume, fat content (FF) and glucose uptake (GU) from whole-body [18F]FDG-PET/MR images. Twelve subjects underwent whole-body [18F]FDG-PET/MRI during hyperinsulinemic-euglycemic clamp. Automated analysis of tissue volumes, FF and GU were achieved using image registration to a single atlas image with reference segmentations of 18 volume of interests (VOIs). Manual segmentations by an experienced radiologist were used as reference. Quantification accuracy was assessed with Dice scores, group comparisons and correlations. VOI Dice scores ranged from 0.93 to 0.32. Muscles, brain, VAT and liver showed the highest scores. Pancreas, large and small intestines demonstrated lower segmentation accuracy and poor correlations. Estimated tissue volumes differed significantly in 8 cases. Tissue FFs were often slightly but significantly overestimated. Satisfactory agreements were observed in most tissue GUs. Automated tissue identification and characterization using a single atlas segmentation performs well compared to manual segmentation in most tissues and will be valuable in future studies. In certain tissues, alternative quantification methods or improvements to the current approach is needed.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f4f1087632187b4f3da2c0a0aa8a307Test
http://link.springer.com/article/10.1038/s41598-020-62353-9Test

7

Macrophage-derived secretome is sufficient to confer olanzapine-mediated insulin resistance in human adipocytes

المؤلفون: Priya Dipta, Maria J. Pereira, Francesca Forno, Miriam Shmuel, Martin Wabitsch, Morten Thaysen-Andersen, Boaz Tirosh, Xesús Abalo, Jan W. Eriksson, Assel Sarsenbayeva

المصدر: Comprehensive Psychoneuroendocrinology, Vol 7, Iss, Pp 100073-(2021)

الوصف: Objective Olanzapine and Aripiprazole are widely used second-generation antipsychotic drugs. Olanzapine, more than Aripiprazole, leads to considerable metabolic side effects including obesity and diabetes. While the underlying mechanisms are not fully understood, these side effects are likely associated with mild inflammation in the metabolic organs. An in vitro model that accurately recapitulates the metabolic impact of olanzapine and aripiprazole should be useful to elucidate the underlying mechanisms. Methods We established co-cultures of matured adipocytes derived from the human SGBS cell line and the THP-1 human monocytic cell-derived or primary macrophages to explore the effects of both drugs on the response to insulin. Results Olanzapine, but not aripiprazole induced insulin resistance in SGBS adipocytes only when co-cultured with THP-1 or primary macrophages, polarized either into M0, M1 or M2. Noteworthy, M2 macrophages induced olanzapine-dependent insulin resistance in the absence of induction of pro-inflammatory cytokines. Insulin resistance by olanzapine was stronger than induced by high concentration of pro-inflammatory cytokines even in combinations, suggesting the contribution of factors other than the classical inflammatory cytokines to promote insulin resistance in adipocytes by olanzapine. Conclusion Macrophage/adipocyte co-cultures recapitulate the features of olanzapine-induced insulin resistance and implicate the existence of yet unknown factors in mediating this effect.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b227af01f8da496562dc35169709ca73Test
http://www.sciencedirect.com/science/article/pii/S2666497621000473Test

8

Das kardiorenale Syndrom ist die häufigste erste kardiovaskuläre Manifestation beim Typ-2-Diabetes und mit erhöhter Mortalität assoziiert: eine große multinationale Beobachtungsstudie

المؤلفون: Jan W. Eriksson, Anna Norhammar, M Thuresson, Y Toshitaka, Marc Pignot, Johan Bodegard, K Issei, E Garal-Pantaler, Takashi Kadowaki, Kåre I. Birkeland, D Anderson

المصدر: Präzisionsmedizin – Eine Reise in die Zukunft der Diabetologie www.diabeteskongress.de.

مصطلحات موضوعية: business.industry, Medicine, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::51d78476cab2bb468336254500671b65Test
https://doi.org/10.1055/s-0041-1727454Test

9

Effects of Gastric Bypass Surgery on the Brain; Simultaneous Assessment of Glucose Uptake, Blood Flow, Neural Activity and Cognitive Function during Normo- and Hypoglycemia

المؤلفون: Sofia Kvernby, Kristina E. Almby, Niclas Abrahamsson, Malin Gingnell, Maria J. Pereira, F. Anders Karlsson, Giovanni Fanni, Sven Haller, Markus Fahlström, Johan Wikström, Jan W. Eriksson, Martin Lundqvist, Urban Wiklund, Magnus Sundbom, Mark Lubberink

الوصف: While Roux-en-Y gastric bypass (RYGB) surgery in obese individuals typically improves glycemic control and prevents diabetes, it also frequently causes asymptomatic hypoglycemia. Previous work showed attenuated counterregulatory responses following RYGB. The underlying mechanisms as well as the clinical consequences are unclear. In this study, 11 subjects without diabetes with severe obesity were investigated pre- and post-RYGB during hyperinsulinemic normo-hypoglycemic clamps. Assessments were made of hormones, cognitive function, cerebral blood flow by arterial spin labeling, brain glucose metabolism by 18F-fluorodeoxyglucose (FDG) positron emission tomography, and activation of brain networks by functional MRI. Post- versus presurgery, we found a general increase of cerebral blood flow but a decrease of total brain FDG uptake during normoglycemia. During hypoglycemia, there was a marked increase in total brain FDG uptake, and this was similar for post- and presurgery, whereas hypothalamic FDG uptake was reduced during hypoglycemia. During hypoglycemia, attenuated responses of counterregulatory hormones and improvements in cognitive function were seen postsurgery. In early hypoglycemia, there was increased activation post- versus presurgery of neural networks in brain regions implicated in glucose regulation, such as the thalamus and hypothalamus. The results suggest adaptive responses of the brain that contribute to lowering of glycemia following RYGB, and the underlying mechanisms should be further elucidated.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a7c0ebcf1ed74dcd7c2554a0552c36bTest
https://doi.org/10.2337/figshare.14114159.v1Test

10

Cardiovascular and Renal Disease Burden in Type 1 Compared With Type 2 Diabetes: A Two-Country Nationwide Observational Study

المؤلفون: Marcus Thuresson, David Nathanson, Robin Kristófi, Thomas Nyström, Kåre I. Birkeland, Johan Bodegard, Anna Norhammar, Jan W. Eriksson

المصدر: Diabetes Care

مصطلحات موضوعية: Adult, endocrine system, Cardiovascular and Metabolic Risk, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, Myocardial Infarction, 030209 endocrinology & metabolism, Type 2 diabetes, 03 medical and health sciences, 0302 clinical medicine, Cost of Illness, Internal medicine, Diabetes mellitus, Internal Medicine, Humans, Medicine, 030212 general & internal medicine, Myocardial infarction, Stroke, Disease burden, Aged, Heart Failure, Advanced and Specialized Nursing, Type 1 diabetes, business.industry, Proportional hazards model, nutritional and metabolic diseases, Middle Aged, medicine.disease, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, business, Kidney disease

الوصف: OBJECTIVE Type 1 diabetes (T1D) and type 2 diabetes (T2D) increase risks of cardiovascular (CV) and renal disease (CVRD) compared with diabetes-free populations. Direct comparisons between T1D and T2D are scarce. We examined this by pooling full-population cohorts in Sweden and Norway. RESEARCH DESIGN AND METHODS A total of 59,331 patients with T1D and 484,241 patients with T2D, aged 18–84 years, were followed over a mean period of 2.6 years from 31 December 2013. Patients were identified in nationwide prescribed drug and hospital registries in Norway and Sweden. Prevalence and event rates of myocardial infarction (MI), heart failure (HF), stroke, chronic kidney disease (CKD), all-cause death, and CV death were assessed following age stratification in 5-year intervals. Cox regression analyses were used to estimate risk. RESULTS The prevalence of CV disease was similar in T1D and T2D across age strata, whereas CKD was more common in T1D. Age-adjusted event rates comparing T1D versus T2D showed that HF risk was increased between ages 65 and 79 years, MI between 55 and 79 years, and stroke between 40 and 54 years (1.3–1.4-fold, 1.3–1.8-fold, and 1.4–1.7-fold, respectively). CKD risk was 1.4–3.0-fold higher in T1D at all ages. The all-cause death risk was 1.2–1.5-fold higher in T1D at age >50 years, with a similar trend for CV death. CONCLUSIONS Adult patients with T1D compared with those with T2D had an overall greater risk of cardiorenal disease (HF and CKD) across ages, MI and all-cause death at middle-older ages, and stroke at younger ages. The total age-adjusted CVRD burden and risks were greater among patients with T1D compared with those with T2D, highlighting their need for improved prevention strategies.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b046de6bdf9453ae1c1ed8b4f3642dcTest
https://doi.org/10.2337/figshare.13721689.v1Test

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