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Improved cardiac and venous pressures during hospital stay in patients with acute heart failure: an echocardiography and biomarkers study

التفاصيل البيبلوغرافية
العنوان: Improved cardiac and venous pressures during hospital stay in patients with acute heart failure: an echocardiography and biomarkers study
المؤلفون: Alain Cohen-Solal, Jean-Marie Launay, Carolyn S.P. Lam, Rui Plácido, Alexandre Mebazaa, Faiez Zannad, Nicolas Girerd, Kamilė Čerlinskaitė, Patrick Rossignol, Marc Badoz, Raphaël Cinotti, Marie-France Seronde, Gad Cotter, Wilfried Mullens, Jeffrey M. Testani, Lucas Van Aelst, Eiichi Akiyama, Etienne Gayat, Mattia Arrigo, Tahar Chouihed
المساهمون: Arrigo, Mattia/0000-0003-4028-2869, Placido, Rui/0000-0003-4164-5481, Cardiovascular Centre (CVC), BOZEC, Erwan, Combattre l'insuffisance cardiaque - - FIGHT-HF2015 - ANR-15-RHUS-0004 - RHUS - VALID, The MEtabolic Road to DIAstolic Heart Failure - MEDIA - - EC:FP7:HEALTH2011-01-01 - 2016-06-30 - 261409 - VALID, Division of Cardiology, Yokohama City University Medical Center, Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Centre hospitalier universitaire de Nantes (CHU Nantes), Clinic of Cardiac and Vascular Diseases, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Service de cardiologie (APHP-Hôpital Lariboisière), Hôpital Lariboisière-APHP, Department of Cardiology, University Heart Center, University Hospital Zurich, Département d’Anesthésie-Réanimation-SMUR [Hôpital Lariboisière], Hôpitaux Universitaire Saint-Louis, Lariboisière, Fernand-Widal, Cardiology Department, Santa Maria University Hospital (CHLN), Lisbon Academic Medical Centre, and Centro Cardiovascular da Universidade de Lisboa, Faculdade de Medicina, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), UFR de Médicine, Sorbonne Paris Cité, Paris Diderot University, Paris, Service d’Accueil des urgences [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre d'investigation clinique plurithématique Pierre Drouin [Nancy] (CIC-P), Centre d'investigation clinique [Nancy] (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Cardiovascular and Renal Clinical Trialists [Vandoeuvre-les-Nancy] (INI-CRCT), Institut Lorrain du Coeur et des Vaisseaux Louis Mathieu [Nancy], French-Clinical Research Infrastructure Network - F-CRIN [Paris] (Cardiovascular & Renal Clinical Trialists - CRCT ), Department of Cardiology, University Hospital Jean Minjoz, Department of Medical Biochemistry and Molecular Biology, Hôpital Lariboisière, Center for Biological Resources BB-033-00064, Hôpital Lariboisière, Université Sorbonne Paris Cité (USPC), Department of Cardiology, Hôpitaux Universitaires Saint Louis-Lariboisière, Assistance Publique des Hopitaux de Paris, National Heart Centre Singapore (NHCS), Duke-National University of Singapore Graduate Medical School, University Medical Center Groningen [Groningen] (UMCG), Yale School of Medicine [New Haven, Connecticut] (YSM), Department of Cardiology, Ziekenhuis Oost-Limburg, Genk, Hasselt University (UHasselt), Momentum Research Inc., Durham, Department of Anesthesiology and Critical Care, Hôpitaux Universitaires Saint Louis-Lariboisiere, Assistance Publique des Hopitaux de Paris, This study was supported by a grant from the European Union funded by the Seventh Framework Programme for Health in 2010 (FP7-HEALTH-2010-MEDIA, Luxembourg) (F.Z., P.R., A. M) and research fellowship from Japan Heart Foundation (E. A.). P.R., N.G., T.C., and F.Z. are supported by a public grant overseen by the French National Research Agency (ANR) as part of the second 'Investissements d’Avenir' programmes Fighting Heart Failure (reference: ANR-15-RHU-0004), GEENAGE Impact Lorraine Université d’Excellence and by the Contrat de Plan Etat Région Lorraine IT2MP and FEDER Lorraine., IMPACT GEENAGE, ANR-15-RHUS-0004,FIGHT-HF,Combattre l'insuffisance cardiaque(2015), European Project: 261409,EC:FP7:HEALTH,FP7-HEALTH-2010-single-stage,MEDIA(2011), Repositório da Universidade de Lisboa, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP)-Université Sorbonne Paris Nord, Department of Cardiovascular Sciences, Centre for Molecular and Vascular Biology, KU Leuven, UFR de Médecine - Sorbonne Paris Cité (Université Paris Diderot - Paris 7 - UPD7), Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU), Yale University School of Medicine
المصدر: ESC Heart Failure, Vol 7, Iss 3, Pp 996-1006 (2020)
ESC Heart Failure, 7(3), 996-1006. WILEY PERIODICALS, INC
ESC Heart Failure
ESC Heart Failure, 2020, 7 (3), pp.996-1006. ⟨10.1002/ehf2.12645⟩
Repositório Científico de Acesso Aberto de Portugal
Repositório Científico de Acesso Aberto de Portugal (RCAAP)
instacron:RCAAP
ESC Heart Failure, Wiley, 2020, 7 (3), pp.996-1006. ⟨10.1002/ehf2.12645⟩
ESC Heart Failure, San Francusco : Wiley, 2020, vol. 7, no. 3, p. 996-1006
بيانات النشر: WILEY PERIODICALS, INC, 2020.
سنة النشر: 2020
مصطلحات موضوعية: Cardiac output, lcsh:Diseases of the circulatory (Cardiovascular) system, Cardiac & Cardiovascular Systems, Cardiac index, 030204 cardiovascular system & hematology, Heart fail- ure with reduced ejection fraction, Ventricular Function, Left, RECOMMENDATIONS, CONGESTION, 0302 clinical medicine, MARKERS, Original Research Articles, Original Research Article, 030212 general & internal medicine, OUTCOMES, Ejection fraction, Diastolic heart failure, ASSOCIATION, Prognosis, Heart failure with reduced ejection fraction, EUROPEAN-SOCIETY, 3. Good health, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Heart failure with preserved ejection fraction, medicine.vein, Echocardiography, Cardiology, Congestion, Cardiology and Cardiovascular Medicine, Life Sciences & Biomedicine, medicine.medical_specialty, RENAL-FUNCTION, Renal function, PULMONARY-EDEMA, Inferior vena cava, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, SOLUBLE CD146, medicine, Humans, PLASMA-VOLUME, acute heart failure, biomarker, congestion, echocardiography, heart failure with preserved ejection fraction, heart failure with reduced ejection fraction, Heart Failure, Science & Technology, business.industry, Acute heart failure, Stroke Volume, Biomarker, Length of Stay, medicine.disease, lcsh:RC666-701, Heart failure, Cardiovascular System & Cardiology, business, Venous Pressure, Biomarkers
الوصف: © 2020 The Authors. ESC Heart Failure published by John Wiley & Sons Ltd on behalf of the European Society of Cardiology. This is an open access article under the terms of the Creative Commons Attribution-Non Commercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Aims: Changes in echocardiographic parameters and biomarkers of cardiac and venous pressures or estimated plasma volume during hospitalization associated with decongestive treatments in acute heart failure (AHF) patients with either preserved left ventricular ejection fraction (LVEF) (HFPEF) or reduced LVEF (HFREF) are poorly assessed. Methods and results: From the metabolic road to diastolic heart failure: diastolic heart failure (MEDIA‐DHF) study, 111 patients were included in this substudy: 77 AHF (43 HFPEF and 34 HFREF) and 34 non‐cardiac dyspnea patients. Echocardiographic measurements and blood samples were obtained within 4 h of presentation at the emergency department and before hospital discharge. In AHF patients, echocardiographic indices of cardiac and venous pressures, including inferior vena cava diameter [from 22 (16–24) mm to 13 (11–18) mm, P = 0.009], its respiratory variability [from 32 (8–44) % to 43 (29–70) %, P = 0.04], medial E/e' [from 21.1 (15.8–29.6) to 16.6 (11.7–24.3), P = 0.004], and E wave deceleration time [from 129 (105–156) ms to 166 (128–203) ms, P = 0.003], improved during hospitalization, similarly in HFPEF and HFREF patients. By contrast, no changes were seen in non‐cardiac dyspnea patients. In AHF patients, all plasma biomarkers of cardiac and venous pressures, namely B‐type natriuretic peptide [from 935 (514–2037) pg/mL to 308 (183–609) pg/mL, P < 0.001], mid‐regional pro‐atrial natriuretic peptide [from 449 (274–653) pmol/L to 366 (242–549) pmol/L, P < 0.001], and soluble CD‐146 levels [from 528 (406–654) ng/mL to 450 (374–529) ng/mL, P = 0.003], significantly decreased during hospitalization, similarly in HFPEF and HFREF patients. Echocardiographic parameters of cardiac chamber dimensions [left ventricular end‐diastolic volume: from 120 (76–140) mL to 118 (95–176) mL, P = 0.23] and cardiac index [from 2.1 (1.6–2.6) mL/min/m2 to 1.9 (1.4–2.4) mL/min/m2, P = 0.55] were unchanged in AHF patients, except tricuspid annular plane systolic excursion (TAPSE) that improved during hospitalization [from 16 (15–19) mm to 19 (17–21) mm, P = 0.04]. Estimated plasma volume increased in both AHF [from 4.8 (4.2–5.6) to 5.1 (4.4–5.8), P = 0.03] and non‐cardiac dyspnea patients (P = 0.01). Serum creatinine [from 1.18 (0.90–1.53) to 1.19 (0.86–1.70) mg/dL, P = 0.89] and creatinine‐based estimated glomerular filtration rate [from 59 (40–75) mL/min/1.73m2 to 56 (38–73) mL/min/1.73m2, P = 0.09] were similar, while plasma cystatin C [from 1.50 (1.20–2.27) mg/L to 1.78 (1.33–2.59) mg/L, P < 0.001] and neutrophil gelatinase associated lipocalin (NGAL) [from 127 (95–260) ng/mL to 167 (104–263) ng/mL, P = 0.004] increased during hospitalization in AHF. Conclusions: Echocardiographic parameters and plasma biomarkers of cardiac and venous pressures improved during AHF hospitalization in both acute HFPEF and HFREF patients, while cardiac chamber dimensions, cardiac output, and estimated plasma volume showed minimal changes.
This study was supported by a grant from the European Union funded by the Seventh Framework Programme for Health in 2010 (FP7-HEALTH-2010-MEDIA; Luxembourg) (F.Z., P.R., A. M) and research fellowship from Japan Heart Foundation (E. A.). P.R., N.G., T.C., and F.Z. are supported by a public grant overseen by the French National Research Agency (ANR) as part of the second “Investissements d’Avenir” programmes Fighting Heart Failure (reference: ANR-15-RHU-0004), GEENAGE Impact Lorraine Université d’Excellence and by the Contrat de Plan Etat Lorraine IT2MP and FEDER Lorraine. LNLVA is supported by a training grant from the European Society of Cardiology (2015) and a travelling award from the International Society for Heart and Lung Transplantation (August 2015 and 2016). LNLVA gratefully acknowledges the financial support from the Fund for Cardiac Surgery through the Jacqueline Bernheim prize 2015.
وصف الملف: Print-Electronic; application/pdf
اللغة: English
تدمد: 2055-5822
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::812a0d63c6e6b166485cf0e9d08808e2Test
https://lirias.kuleuven.be/handle/20.500.12942/703063Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....812a0d63c6e6b166485cf0e9d08808e2
قاعدة البيانات: OpenAIRE
الوصف
تدمد:20555822