المؤلفون: Caroline Ovaert, Sylvie Tuffery-Giraud, Sarah Leonard-Louis, Anthony Béhin, Sophie Guillaumont, Maximilien Sochala, Emmanuelle Campana-Salort, Frédérique Audic, Michèle Mayer, Damien Bonnet, Raul Juntas Morales, Mireille Cossée, Isabelle Desguerre, Christophe Meune, Pascal Laforêt, Rabah Ben Yaou, Brigitte Chabrol, Djillali Annane, David Orlikowski, François Godart, Malika Saadi, Helge Amthor, Tanya Stojkovic, Ulrike Walther-Louvier, Frédéric Lofaso, Pascal Amedro, Raphaël Porcher, Céline Tard, Claire Delcourte, Vincent Tiffreau, Karim Wahbi, Christine Barnerias, Guillaume Bassez, Bertrand Fontaine, Arnaud Isapof, Gregoire De La Villeon, Guy Vaksmann, François Rivier, Denis Duboc, Henri Marc Bécane, Philippe Ravaud, Hélène Prigent, Emmanuelle Jaillette, Abdallah Fayssoil, Bruno Eymard

المساهمون: Université de Lille, Univ. Artois, Univ. Littoral Côte d’Opale, Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 [URePSSS], Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Physiologie & médecine expérimentale du Cœur et des Muscles [U 1046] (PhyMedExp), Université de Montpellier (UM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologies appliquées (END-ICAP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Département de génétique médicale [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE)-Institut National de la Santé et de la Recherche Médicale (INSERM), Clinique de pneumologie [CHRU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), CHU Trousseau [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Unité de Recherche Pluridisciplinaire Sport, Santé, Société (URePSSS) - ULR 7369 - ULR 4488 (URePSSS), Université d'Artois (UA)-Université du Littoral Côte d'Opale (ULCO)-Université de Lille, Neurologie, maladies neuro-musculaires [Hôpital de la Timone - APHM], Aix Marseille Université (AMU)-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), CHU Pitié-Salpêtrière [AP-HP], Hôpital Cochin [AP-HP], Centre de recherche en Myologie – U974 SU-INSERM, Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), Filière Neuromusculaire (FILNEMUS), Infection et inflammation (2I), Université de Montpellier (UM), Centre Hospitalier de Versailles André Mignot (CHV), Institut des Neurosciences de Montpellier (INM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Marqueurs cardiovasculaires en situation de stress (MASCOT (UMR_S_942 / U942)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Centre d’Investigation Clinique 1429 [Garches] (CIC 1429), Hôpital Raymond Poincaré [AP-HP]-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de cardiologie Pédiatrique [Marseille], Hôpital de la Timone [CHU - APHM] (TIMONE), Hôpital Raymond Poincaré [AP-HP], Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)

المصدر: European Heart Journal
European Heart Journal, Oxford University Press (OUP): Policy B, 2021, ⟨10.1093/eurheartj/ehab054⟩
European Heart Journal, 2021, ⟨10.1093/eurheartj/ehab054⟩

مصطلحات موضوعية: Duchenne muscular dystrophy, medicine.medical_specialty, [SDV]Life Sciences [q-bio], Cardiomyopathy, Angiotensin-Converting Enzyme Inhibitors, Heart failure, Angiotensin-converting enzyme inhibitors, 030204 cardiovascular system & hematology, Lower risk, Ventricular Function, Left, Angiotensin Receptor Antagonists, 03 medical and health sciences, 0302 clinical medicine, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, Internal medicine, medicine, Humans, Registries, cardiovascular diseases, 030212 general & internal medicine, Medical prescription, Child, ComputingMilieux_MISCELLANEOUS, Heart Failure, biology, business.industry, Proportional hazards model, Hazard ratio, Angiotensin-converting enzyme, medicine.disease, Confidence interval, 3. Good health, Muscular Dystrophy, Duchenne, Treatment Outcome, Child, Preschool, biology.protein, Cardiology and Cardiovascular Medicine, business, cardiomyopathy

الوصف: Aims To estimate the effect of prophylactic angiotensin-converting enzyme inhibitors (ACEi) on survival in Duchenne muscular dystrophy (DMD). Methods and results We analysed the data from the French multicentre DMD Heart Registry (ClinicalTrials.gov: NCT03443115). We estimated the association between the prophylactic prescription of ACEi and event-free survival in 668 patients aged 8 to 13 years, with normal left ventricular function, using (i) a Cox model with intervention as a time-dependent covariate, (ii) a propensity-based analysis comparing ACEi treatment vs. no treatment, and (iii) a set of sensitivity analyses. The study outcomes were overall survival and hospitalizations for heart failure (HF) or acute respiratory failure. Among the 668 patients included in the DMD Heart Registry, 576 (mean age 6.1 ± 2.8 years) were eligible for this study, of whom 390 were treated with ACEi prophylactically. Death occurred in 53 patients (13.5%) who were and 60 patients (32.3%) who were not treated prophylactically with ACEi, respectively. In a Cox model with intervention as a time-dependent variable, the hazard ratio (HR) associated with ACEi treatment was 0.49 [95% confidence interval (CI) 0.34–0.72] and 0.47 (95% CI 0.31–0.17) for overall mortality after adjustment for baseline variables. In the propensity-based analysis, 278 patients were included in the treatment group and 834 in the control group, with 18.5% and 30.4% 12-year estimated probability of death, respectively. ACEi were associated with a lower risk of death (HR 0.39; 95% CI 0.17–0.92) and hospitalization for HF (HR 0.16; 95% CI 0.04–0.62). All other sensitivity analyses yielded similar results. Conclusion Prophylactic ACEi treatment in DMD was associated with a significantly higher overall survival and lower rates of hospitalization for HF.

وصف الملف: application/octet-stream

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f84a4eeaae527cf105631ef315b278f7Test
https://doi.org/10.1093/eurheartj/ehab054Test

المؤلفون: Aurélien Mulliez, Vivien Reynaud, Marie-Christine Durand, Hélène Prigent, Frédéric Lofaso

المصدر: Muscle & Nerve. 63:327-335

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, medicine.medical_specialty, Physiology, Neural Conduction, Phrenic nerve conduction, Diagnostic accuracy, 030105 genetics & heredity, Diaphragmatic paralysis, Sensitivity and Specificity, Pulmonary function testing, 03 medical and health sciences, Cellular and Molecular Neuroscience, Esophagus, 0302 clinical medicine, Predictive Value of Tests, Physiology (medical), Internal medicine, mental disorders, Pressure, Transducers, Pressure, medicine, Respiratory muscle, Humans, Aged, Retrospective Studies, business.industry, Electrodiagnosis, Stomach, Transdiaphragmatic pressure, Middle Aged, Respiratory Paralysis, Predictive value, Respiratory Muscles, Respiratory Function Tests, Highly sensitive, Phrenic Nerve, Cardiology, Female, Neurology (clinical), business, 030217 neurology & neurosurgery

الوصف: BACKGROUND Unilateral diaphragmatic paralysis (UDP) has major clinical and etiological implications and, therefore, is important to diagnose. Lung function tests and invasive transdiaphragmatic pressure (Pdi) measurements are widely used to this end but, contrary to phrenic nerve conduction study (NCS), they require volitional maneuvers and/or may be poorly tolerated by patients. The purpose of this study was to compare the diagnostic accuracy of Pdi and phrenic NCS for UDP. METHODS We retrospectively reviewed 28 patients with suspected UDP. The diagnosis established during a multidisciplinary meeting was the reference standard. RESULTS Phrenic NCS correlated well with Pdi (r = 0.82, P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e12c907a7cc46300b897a91d49927b4Test
https://doi.org/10.1002/mus.27144Test

المؤلفون: Bruno Louis, Karl Leroux, Ghilas Boussaïd, Hélène Prigent, Frédéric Lofaso

المساهمون: Equipe de Recherche Paramédicale sur le Handicap NeuroMoteur (ERPHAN), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay, Handicap neuromusculaire : Physiopathologie, Biothérapie et Pharmacologies appliquées (END-ICAP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Molecular virology and immunology – Physiopathology and therapeutic of chronic viral hepatitis (Team 18) (Inserm U955), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Biomécanique & Appareil Respiratoire (BAR), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Centre National de la Recherche Scientifique (CNRS)

المصدر: Respiratory Care
Respiratory Care, Daedalus Enterprises Inc, 2020, 65 (9), pp.1258-1267. ⟨10.4187/respcare.07213⟩

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, medicine.medical_specialty, Central sleep apnea, Respiratory rate, [SDV]Life Sciences [q-bio], Hyperpnea, Critical Care and Intensive Care Medicine, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, bench study, Tidal Volume, medicine, Humans, Cheyne-Stokes Respiration, Tidal volume, servomechanism, Continuous Positive Airway Pressure, lung model, adaptive servo ventilation, business.industry, pressure support, non-invasive ventilation, Hypoventilation, General Medicine, medicine.disease, Sleep Apnea, Central, 030228 respiratory system, Breathing, Cardiology, Transient (oscillation), medicine.symptom, business, Hypopnea

الوصف: BACKGROUND: Adaptive servoventilation (ASV) is a recently developed ventilation mode designed to stabilize ventilation in patients with central sleep apnea and Cheyne-Stokes respiration. Alternatively, modes aiming to maintain average ventilation over several breaths, such as average volume-assured pressure support (AVAPS) and intelligent volume-assured pressure support (iVAPS), could be efficient during ventilation instability by reducing central events. These modes are available on a variety of devices. This bench evaluation studied the response of these different modes and devices to simulated transient hypoventilation events. METHODS: Three home ventilation devices operating in ASV modes (AirCurve 10 CS Pacewave, ResMed; DreamStation autoSV, Philips; Prisma CR, Lowenstein) and 2 ventilators with the AVAPS mode (DreamStation BiPAP, Philips; Lumis 150 iVAPS, ResMed) were evaluated during transient central hypopnea/hypoventilation simulations characterized by a constant breathing frequency of 15 breaths/min and a progressive decrease of tidal volume (VT) from 500 mL to 50 mL, in 18, 12, 9, and 6 breaths, respectively, followed by a progressive return to the baseline at the same rate. RESULTS: The AirCurve 10 CS Pacewave reacted to a VT decrease between 80% and 50% of baseline VT. DreamStation BiPAP and Prisma CR reacted when VT decreased to between 60% and 30% of baseline VT, whereas the AVAPS response to hypopnea occurred during the crescendo phase of hypopnea/hypoventilation VT. The iVAPS response was between that of the AirCurve 10 CS Pacewave and the other ASV devices. Among the ASV devices, the minimum VT was higher with AirCurve 10 CS Pacewave, followed by the Prisma CR and the DreamStation BiPAP. Minimum VT was not influenced by AVAPS and was improved by iVAPS without outperforming the AirCurve 10 CS Pacewave. Maximum VT was increased by iVAPS, whereas ASV devices did not induce a significant VT overshoot. CONCLUSIONS: ASV devices improved central hypopnea/hypoventilation events without inducing hyperpnea events and therefore were better adapted than AVAPS and iVAPS devices, with notable differences in their responses to hypoventilation events.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d1259b8e893b7c1304ed65eb49b4220Test
https://doi.org/10.4187/respcare.07213Test

المؤلفون: Hélène Prigent, Frédéric Lofaso, Nicolas Terzi

المصدر: ERJ Open Research
article-version (VoR) Version of Record
ERJ Open Research, Vol 7, Iss 4 (2021)

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, COPD, medicine.medical_specialty, Exacerbation, business.industry, Conflict of interest, Aspiration pneumonia, medicine.disease, respiratory tract diseases, Open research, Swallowing, Copd exacerbation, Correspondence, Medicine, In patient, business, Intensive care medicine

الوصف: We read with interest the study performed by Gonzalez Lindh et al. [1]. In this cross-sectional study, they reported that COPD patients, hospitalised with an acute exacerbation episode, exhibited significant self-reported and clinically screened swallowing dysfunction. These data are interesting, as they confirm previous physiopathological studies, which could also be of interest to the readers of ERJ Open Research. They aimed to understand the underlying mechanisms that may predispose COPD patients to pneumonia aspiration and exacerbation of COPD [2, 3], and to propose possible solutions to improve vulnerability to aspiration [4]. However, evidence is already available in the literature on these topics.
This correspondence deals with physiopathological studies that aimed to understand the underlying mechanisms of breathing–swallowing interaction https://bit.ly/3BKAwx3Test

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76857b87af7ff8ebd4ab56cef7833588Test
https://pubmed.ncbi.nlm.nih.gov/34708117Test

المؤلفون: Sylvie Chevret, Paris Meng, Pascal Crenn, Cendrine Chaffaut, Bernard Clair, Adam Ogna, Djillali Annane, Hélène Prigent, David Orlikowski, Pascal Laforêt, Abdallah Fayssoil, Frédéric Lofaso

المصدر: Pediatric pulmonologyREFERENCES. 56(7)

مصطلحات موضوعية: Pulmonary and Respiratory Medicine, Adult, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Duchenne muscular dystrophy, Nutritional Status, Sepsis, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Swallowing, 030225 pediatrics, Internal medicine, medicine, Respiratory muscle, Humans, Respiratory function, Respiratory system, Mechanical ventilation, Univariate analysis, business.industry, Swallowing Disorders, medicine.disease, Prognosis, Respiratory Muscles, Deglutition, Muscular Dystrophy, Duchenne, 030228 respiratory system, Pediatrics, Perinatology and Child Health, Median body, business, Deglutition Disorders

الوصف: Malnutrition and swallowing disorders are common in Duchenne muscular dystrophy (DMD) patients. We assessed, in adult DMD with home mechanical ventilation (HMV) and cough assist device, its prevalence and the relationships with respiratory muscle strength and long-term respiratory prognosis. We reviewed the patients (n = 117, age 18-39 years [median 24]), followed in a reference center, from 2006 to 2015, to obtain clinical baseline, nutritional status, vital capacity (VC), maximal inspiratory pressure (MIP), and maximal expiratory pressure (MEP). The median body mass index (BMI) was low (15.6 kg/m²). Included patients had severe restrictive respiratory function with a median VC of 10.5% [7-17] of the predicted value. All patients were on HMV. Prevalence of malnutrition, swallowing disorders, and gastrostomy were respectively 62%, 34%, and 11%. BMI and serum albumin level were significantly associated with MIP, MEP, and VC. The 1-year/5-years cumulative incidences of respiratory events (pulmonary sepsis and acute respiratory distress) were, respectively, 20.7%/44.5%. Using univariate analysis, predictive factors for respiratory events were swallowing disorders (p = .001), transthyretinemia (p = .034), MIP (p = .039), and MEP (p = .03) but not BMI or albuminemia. Using multivariate analysis, only swallowing disorders remained significantly associated with respiratory events (OR = 4.2, IC 95% 1.31-12.2, p = .01). In conclusion, this study highlights the interrelationships between nutritional intake, swallowing function, airway clearance, and respiratory function in adult DMD. A multidisciplinary approach focusing on these previous factors is essential to optimize DMD patient health.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8475a904e8b59112dc2bbfbc3621000cTest
https://pubmed.ncbi.nlm.nih.gov/33939888Test

المؤلفون: Pascal Crenn, Tanya Stojkovic, Dominique Mompoint, Hélène Prigent, David Orlikowski, Helge Amthor, Cendrine Chaffaut, Laure Lamothe, Susana Quijano Roy, Guillaume Bassez, Sylvie Chevret, Djillali Annane, Bernard Clair, Pascal Laforêt, Frédéric Lofaso, Robert Carlier, Paris Meng, Adam Ogna, Anthony Behin, Abdallah Fayssoil, Bruno Eymard

المصدر: Journal of Neuromuscular Diseases. 6:55-64

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Vital capacity, medicine.medical_specialty, Adolescent, Duchenne muscular dystrophy, Diaphragm, Diaphragmatic breathing, Muscle disorder, Pulmonary function testing, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Respiratory muscle, Humans, Medicine, Child, Retrospective Studies, Ultrasonography, business.industry, Respiration, Organ Size, Middle Aged, musculoskeletal system, medicine.disease, Respiration, Artificial, Diaphragm (structural system), Muscular Dystrophy, Duchenne, Cross-Sectional Studies, 030104 developmental biology, Neurology, Cardiology, Median body, Neurology (clinical), business, 030217 neurology & neurosurgery

الوصف: BACKGROUND Duchenne muscular dystrophy (DMD) is an X-linked recessive genetic muscle disorder. Respiratory muscle function is classically affected in this disease. Ultrasound recently emerged as a non-invasive tool to assess diaphragm function. However, there are only a few studies using diaphragm ultrasound (US) in DMD. PURPOSE We aimed to assess diaphragm ultrasound patterns in DMD, their relationship with age and their association with home mechanical ventilation (HMV). METHODS We included DMD patients followed at Raymond Poincare Hospital who benefited from diaphragm ultrasound and pulmonary function tests. RESULTS There were 110 DMD patients and 17 male sex-matched healthy subjects included. In all, 94% of patients were permanent wheelchair users. Median body mass index (BMI) was 18 kg/m2. DMD patients disclosed a reduced forced vital capacity (VC) (12% of predicted value), and 78% of patients were on HMV. In patients, right and left diaphragmatic motions on deep inspiration were reduced and end expiratory diaphragm thickness was borderline normal. In patients, right and left diaphragmatic thickening fractions (TF) were reduced 12.7% and 15.5%, respectively. Age and end expiratory thickness were significantly inversely associated (p = 0.005 for the right diaphragm, p = 0.018 for the left diaphragm). Diaphragm TF was significantly inversely associated with age (p = 0.001 for the right side, p

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54576aaa09a075dc125c0779852f4c1bTest
https://doi.org/10.3233/jnd-180326Test

المؤلفون: Lorena Del Amo Castrillo, Aurélien Boré, Isabelle Vaugier, Line Falaize, Hélène Prigent, Frédéric Lofaso, Matthieu Lacombe, David Orlikowski

المصدر: Respiratory Care. 64:255-261

مصطلحات موضوعية: Adult, Male, Pulmonary and Respiratory Medicine, Respiratory Therapy, Neuromuscular disease, medicine.medical_treatment, Home Care Services, Hospital-Based, Peak Expiratory Flow Rate, Critical Care and Intensive Care Medicine, Continuous mandatory ventilation, Cohort Studies, Inspiratory Capacity, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Tidal Volume, Respiratory muscle, Humans, Medicine, Tidal volume, Aged, Retrospective Studies, Mechanical ventilation, Ventilators, Mechanical, business.industry, Neuromuscular Diseases, General Medicine, Middle Aged, Prognosis, medicine.disease, Respiration, Artificial, Treatment Outcome, Cough, 030228 respiratory system, Respiratory failure, Intermittent positive pressure breathing, Anesthesia, Female, France, Respiratory Insufficiency, business

الوصف: BACKGROUND: Breath-stacking, which consists of taking 2 or more consecutive ventilator insufflations without exhaling, is a noninvasive and inexpensive cough-assistance technique for patients with neuromuscular disease. Volumetric cough mode (VCM) is a recently introduced ventilator mode consisting of a programmable intermittent deep breath equal to a set percentage of the baseline tidal volume. Here, our objective was to compare VCM to breath-stacking during volume-control continuous mandatory ventilation in subjects on long-term noninvasive mechanical ventilation at home. METHODS: We included 20 subjects with neuromuscular disease causing severe respiratory muscle dysfunction with a cough peak flow (CPF) RESULTS: CPF increased with both techniques but was higher with VCM than with breath-stacking in 16 subjects. In 17 subjects, CPF was highest with the technique that produced the greatest inspiratory capacity. CONCLUSION: Our results indicate that both breath-stacking and VCM are useful cough-augmentation techniques. Displaying insufflated volumes on the ventilator screen is a simple and accessible method for selecting the most efficient cough-augmentation technique delivered by a home ventilator.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2b7cba80dfbe23f245439d7fafc05103Test
https://doi.org/10.4187/respcare.06259Test

المؤلفون: Vincent Delord, Julie Paquereau, Christine Lawrence, Frédéric Lofaso, Hélène Prigent, Simon Bessis, Antoine Léotard, Jonathan I. Levy, Djillali Annane, Djamel Bensmail

المصدر: Annals of Physical and Rehabilitation Medicine

مصطلحات موضوعية: Male, medicine.medical_specialty, 2019-20 coronavirus outbreak, Critical Care, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Pneumonia, Viral, Anxiety, Hospitals, University, Patient Isolation, Stress Disorders, Post-Traumatic, Betacoronavirus, Patients' Rooms, medicine, Humans, Hospital Design and Construction, Orthopedics and Sports Medicine, Pandemics, Aged, Patient Care Team, Muscle Weakness, Ventilators, Mechanical, Ventilator weaning, SARS-CoV-2, business.industry, Rehabilitation, COVID-19, Delirium, Length of Stay, Middle Aged, Respiration, Artificial, Paresis, Patient room, Emergency medicine, Female, France, medicine.symptom, Coronavirus Infections, business, Hospital Units, Ventilator Weaning, Early rehabilitation, Hypoalbuminemia

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5befe5f5b18b0dd8ab2b12f7aeaca56Test

المؤلفون: Hélène Prigent, Frédéric Lofaso, Pascal Laforêt, Ghilas Boussaïd, Jean-Claude Raphaël, Djillali Annane, David Orlikowski

المصدر: Thorax. 73:1075-1078

مصطلحات موضوعية: Adult, Male, Pulmonary and Respiratory Medicine, medicine.medical_specialty, medicine.medical_treatment, Myotonic dystrophy, Home ventilation, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Humans, Myotonic Dystrophy, Medicine, Non-invasive ventilation, In patient, Prospective Studies, Prospective cohort study, Mechanical ventilation, Proportional hazards model, business.industry, Prognosis, medicine.disease, Respiration, Artificial, Respiratory Function Tests, Survival Rate, 030228 respiratory system, Breathing, Patient Compliance, Female, France, Respiratory Insufficiency, business, 030217 neurology & neurosurgery, Follow-Up Studies

الوصف: Few studies have assessed the impact of home ventilation in patients with myotonic dystrophy type 1 (DM1) and no specific recommendations are available. We assessed the survival associated with category of home ventilation adherence of patients with DM1 followed up at a home ventilation unit using a Cox proportional hazards model. 218 patients were included; those who refused or delayed their acceptance of non-invasive ventilation were at higher risk for severe events (invasive ventilation or death) (P=0.03). Risk of death was associated with orthopnoea (HR 2.37; 95% CI 1.17 to 4.80; P75%: HR 3.26; 95% CI 1.32 to 8.04; P

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db3dda253991ba12111bff08ddec0e8fTest
https://doi.org/10.1136/thoraxjnl-2017-210610Test

المؤلفون: Tanya Stojkovic, Helge Amthor, David Orlikowski, Hélène Prigent, Djillali Annane, Frédéric Lofaso, Stéphane Vinit, Bernard Clair, Anthony Behin, Arnaud Mansart, Dominique Mompoint, Abdallah Fayssoil, Bruno Eymard, Robert Carlier, Pascal Laforêt, Adam Ogna

المصدر: Journal of Neuromuscular Diseases

مصطلحات موضوعية: medicine.medical_specialty, Diaphragm, Respiratory pattern, Review, neuromuscular disorders, 03 medical and health sciences, 0302 clinical medicine, Respiratory muscle, Medicine, Humans, Respiratory system, Ultrasonography, business.industry, ultrasound, Ultrasound, Neuromuscular Diseases, musculoskeletal system, Pathophysiology, Diaphragm (structural system), 030228 respiratory system, Neurology, Ultrasound imaging, Neurology (clinical), Radiology, business, 030217 neurology & neurosurgery

الوصف: Respiratory muscles are classically involved in neuromuscular disorders, leading to a restrictive respiratory pattern. The diaphragm is the main respiratory muscle involved during inspiration. Ultrasound imaging is a noninvasive, radiation-free, accurate and safe technique allowing assessment of diaphragm anatomy and function. The authors review the pathophysiology of diaphragm in neuromuscular disorders, the methodology and indications of diaphragm ultrasound imaging as well as possible pitfalls in the interpretation of results.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13c8b6d88488a2d0a3d8a4aaf8e04296Test
http://europepmc.org/articles/PMC5836400Test