المؤلفون: Shraddha Sawant, Kailash Chandra Samal, Jyoti Prakash Sahoo, Ankita Mishra, Ankit Moharana, Siddhartha Shankar Sharma, Pranay Pradhan, Jannila Praveena, Asit Ranjan Sahoo, Laxmipreeya Behera, Lipi Ghosh, Subhasmita Sahu, Ambika Prasad Mishra

المصدر: American Journal of Plant Sciences. 12:455-475

مصطلحات موضوعية: Modern medicine, biology, Traditional medicine, business.industry, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), General Medicine, biology.organism_classification, Antimicrobial, chemistry.chemical_compound, Human health, chemistry, Bisdemethoxycurcumin, Curcumin, Medicine, Zingiberaceae, Curcuma, business

الوصف: From the evolution of the mankind, Turmeric has been used in conventional medication. India is in lead for producing, marketing and exporting the Turmeric and its value added products. Curcuma longa (Turmeric) is an Indian rhizomatous medicinal herb from the Zingiberaceae family that is common and widely available across the globe. The components of Turmeric are curcumin, demethoxycurcumin and bisdemethoxycurcumin and these are collectively known as curcuminoids. Curcumin, the active ingredient of Turmeric is generally investigated by the scientific community for its wide range of antioxidant activity, anti-Inflammatory properties and anti-cancer activity, anti-metabolic syndrome activities, neuroprotective activity, antimicrobial effects, anti-arthritis effects, anti-viral effects, anti-asthma and anti-diabetic effects, anti-obesity, cardio and liver toxicity protection activity, anti-depression and anxiety activities. Turmeric has been widely used as a typical household treatment for cough, sore throat, respiratory ailments and could be an effective immunity booster against SARS-CoV-2 therapy during the ongoing pandemic situation. Safety evaluation studies indicate that both turmeric and curcumin are well tolerated at a very high dose without any toxic effects. Thus, turmeric and its constituents have the potential for the development of modern medicine for the treatment of various diseases. So in this review, we describe the various metabolic roles of curcumin and activities for the benefit of human health.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::77ef47b01310d5e56ab94f8502fd2a88Test
https://doi.org/10.4236/ajps.2021.123030Test

المؤلفون: K Gouthamchandra, K Shyamprasad, Siddappa Chandrappa, Amritha Raj, Sudeep Hv

المصدر: SAGE Open Medicine
SAGE Open Medicine, Vol 8 (2020)

مصطلحات موضوعية: Disease, Pharmacology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Bisdemethoxycurcumin, Curcuma longa extract, Medicine, Computational analysis, 030304 developmental biology, Cholinesterase, lcsh:R5-920, 0303 health sciences, biology, business.industry, turmeric, bisdemethoxycurcumin, General Medicine, cholinesterases, Cholinesterase inhibition, chemistry, biology.protein, Original Article, Cognition deficits, lcsh:Medicine (General), business, 030217 neurology & neurosurgery

الوصف: Objectives: Cholinesterase inhibition is a common strategy to treat Alzheimer’s disease. In this study, we have investigated the cholinesterase inhibitory effects of a first-of-its-kind turmeric extract (REVERC3) having enriched content of bisdemethoxycurcumin as major active curcuminoid. Methods: The inhibition studies were performed using Ellman’s colorimetric assay. The kinetics of acetylcholinesterase and butyrylcholinesterase was determined in the presence of REVERC3 using the Lineweaver–Burk double reciprocal plots. Furthermore, we used AutoDock tools to predict the binding of bisdemethoxycurcumin with the active sites of cholinesterases. Results: REVERC3 showed 4.8- and 5.39-fold higher inhibitory potential of acetylcholinesterase and butyrylcholinesterase with IC50 values of 29.08 and 33.59 µg/mL, respectively, compared to the regular turmeric extract. The mode of binding of REVERC3 was competitive in the case of acetylcholinesterase while it was uncompetitive for the inhibition of butyrylcholinesterase. Docking analysis revealed that bisdemethoxycurcumin, the major constituent of REVERC3, has different preferences of binding in the active sites of acetylcholinesterase and butyrylcholinesterase. However, the best binding pose predictions are in line with the experimental binding mode of the cholinesterases. Conclusion: These results indicate that bisdemethoxycurcumin-enriched turmeric extract could improve the cholinergic functions via dual inhibition of cholinesterases. However, the predominant role of bisdemethoxycurcumin in REVERC3 must be further validated using preclinical studies and clinical trials.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c05fc4c9362a6ae951c33e43ae03c69eTest
http://europepmc.org/articles/PMC7686599Test

المؤلفون: Yucheng Liu, Jian Sun, Yonggang Wang, Binay Kumar Adhikari, Xiao Miao, Fengsheng Li, Cheng Li, Quan Liu, Lu Cai, Rong Zhang

المصدر: Phytotherapy Research. 33:1302-1317

مصطلحات موضوعية: Ischemia, Inflammation, Pharmacology, medicine.disease_cause, Pathogenesis, 03 medical and health sciences, chemistry.chemical_compound, Curcuma, 0302 clinical medicine, Bisdemethoxycurcumin, medicine, Animals, Humans, 0303 health sciences, biology, Plant Extracts, business.industry, 030302 biochemistry & molecular biology, medicine.disease, biology.organism_classification, Oxidative Stress, chemistry, Cardiovascular Diseases, 030220 oncology & carcinogenesis, Curcumin, medicine.symptom, business, Reperfusion injury, Oxidative stress

الوصف: It has been extensively verified that inflammation and oxidative stress play important roles in the pathogenesis of cardiovascular diseases (CVDs). Curcuminoids, from the plant Curcuma longa, have three major active ingredients, which include curcumin (curcumin I), demethoxycurcumin, and bisdemethoxycurcumin. Curcuminoids have been used in traditional medicine for CVDs' management and other comorbidities for centuries. Numerous studies had delineated their anti-inflammatory, antioxidative, and other medicinally relevant properties. Animal experiments and clinical trials have also demonstrated that turmeric and curcuminoids can effectively reduce atherosclerosis, cardiac hypertrophy, hypertension, ischemia/reperfusion injury, and diabetic cardiovascular complications. In this review, we introduce and summarize curcuminoids' molecular and biological significance, while focusing on their mechanistic anti-inflammatory/antioxidative involvements in CVDs and preventive effects against CVDs, and, finally, discuss relevant clinical applications.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4a7ec0bab263dff901ee06e7b80a943Test
https://doi.org/10.1002/ptr.6324Test

المؤلفون: Ying Jin, Jiangxia Du, Ziying Zhao, Bo Yang, Liyu Jiang, Fuquan Jin, Peihua Luo, Qiaojun He, Ying Zhang

المصدر: European Journal of Pharmacology. 847:26-31

مصطلحات موضوعية: Male, 0301 basic medicine, Curcumin, Apoptosis, Kidney, Protective Agents, urologic and male genital diseases, Cell Line, Mice, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Pharmacotherapy, Diarylheptanoids, In vivo, Bisdemethoxycurcumin, medicine, Renal fibrosis, Animals, Humans, Renal Insufficiency, Chronic, Urinary Tract, Pharmacology, Biological Products, business.industry, Therapeutic effect, Fibroblasts, Fibrosis, In vitro, Disease Models, Animal, 030104 developmental biology, chemistry, Mechanism of action, Cancer research, Female, medicine.symptom, business, 030217 neurology & neurosurgery, Ureteral Obstruction

الوصف: Renal fibrosis is the common final outcome of nearly all progressive chronic kidney diseases (CKD) that eventually develop into end-stage renal failure, which threatens the lives of patients. Currently, there are no effective drugs for the treatment of renal fibrosis. However, studies have shown that certain plant natural products have a fibrosis-alleviating effect. Thus, we have screened a large number of natural products for their ability to protect against renal fibrosis and found that bisdemethoxycurcumin has a good therapeutic effect in renal fibrosis according to the data obtained in a mouse model of unilateral ureteral obstruction (UUO). The results indicate that bisdemethoxycurcumin can efficiently attenuate renal fibrosis induced by UUO. Additional studies of the bisdemethoxycurcumin mechanism of action in the treatment of renal fibrosis demonstrated that the therapeutic effect of bisdemethoxycurcumin is mediated by the specific induction of fibroblast apoptosis at a concentration of 20 μM. bisdemethoxycurcumin can efficiently protect against renal fibrosis both in vitro and in vivo. This discovery will provide new ideas for renal fibrosis treatment in clinics and a new direction for the development of effective drug therapy of renal fibrosis.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4121c25c767eda54e97d9f1e9ebe6445Test
https://doi.org/10.1016/j.ejphar.2019.01.012Test

المؤلفون: Chassib A. Emshary, Qusay M.A. Hassan, Rita S. Elias, Bahjat A. Saeed, Ahmed S. Al-Asadi, H. Bakr, H.A. Sultan

المصدر: Optical Materials. 85:500-509

مصطلحات موضوعية: Diffraction, Work (thermodynamics), Materials science, Physics::Optics, Near and far field, 02 engineering and technology, Ring (chemistry), 01 natural sciences, Inorganic Chemistry, chemistry.chemical_compound, Optics, 0103 physical sciences, Bisdemethoxycurcumin, Electrical and Electronic Engineering, Physical and Theoretical Chemistry, Spectroscopy, 010302 applied physics, business.industry, Organic Chemistry, 021001 nanoscience & nanotechnology, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials, Nonlinear system, chemistry, Continuous wave, 0210 nano-technology, business, Refractive index

الوصف: In this work, nonlinear optical properties of bisdemethoxycurcumin solution were studied using diffraction ring patterns method. Multiple diffraction rings observed as a continuous wave (CW) laser beam passes through a bisdemethoxycurcumin solution. The nonlinear refractive index, n2, and change in refractive index, Δn, for sample were determined from the number of observed rings, and are found to be 0.8327 × 10−6 cm2/W and 0.00946 respectively. The evolution of the diffraction ring patterns are numerically studied using the Fresnel–Kirchhoff diffraction integral theory. The experimental findings are in good agreement with theoretical analysis. Also the optical limiting properties of the sample were measured at 473 nm. The obtained results proved that the sample bear good optical limiting property.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::83ad16ed8877f68a795c2861741a09bcTest
https://doi.org/10.1016/j.optmat.2018.09.021Test

المؤلفون: Anupam Paliwal, Anjana S. Nair

مصطلحات موضوعية: Drug, Zingerone, business.industry, media_common.quotation_subject, Drug action, Pharmacology, Carnosol, chemistry.chemical_compound, chemistry, Bisdemethoxycurcumin, Curcumin, Medicine, Boswellic acid, business, media_common, Systems pharmacology

الوصف: Chronic inflammation plays crucial role in development and progression of several chronic diseases. Targeting inflammatory processes remains critical for the development of a new generation of drugs to treat conditions including cancers, cardiovascular diseases, arthritis, asthma, type 2 diabetes mellitus, and infectious diseases. Systems pharmacology has been introduced as a comprehensive approach to predict in vivo effects of drug compounds, in which complete biological networks, rather than single signal transduction pathways, are considered as the basis of drug action and disease progression. Using this approach a critical evaluation of existing (steroidal and nonsteroidal) and potential antiinflammatory drug candidates has shed light on their undesired off-target interactions and critical side effects. In this scenario, natural products and phytochemicals known to have potent antiinflammatory properties surprisingly appear as better alternate, with least or minimum side effects and toxicity. Many plants and herbs such as ginger, turmeric, rosemary, boswellia, and galangal and bioactive compounds (curcumin, bisdemethoxycurcumin, tetrahydrocurcumin, demethoxycurcumin, 6-gingerol, zerumbone, zingiberene, zingerone, gingerdiol, 6-shogaol, boswellic acid, acetyl-11-keto-β-boswellic acid, incensole acetate, galangin, limonene, 1,8-cineole, camphor, carnosol, and carnosic acid) derived from them exhibit excellent antioxidant, antibacterial, antiinflammatory, antimicrobial, and anticancer activities. There are emerging evidences indicating that these traditionally proven antiinflammatory natural molecules shall be prioritized as potential drug candidates. Integration of computational strategy like molecular docking (using these natural molecules as bait) with the emerging data from systems biology studies proves that these natural molecules may serve better/safe as antiinflammatory agents. Years of usage of these molecules directly in food (spices/herbs) or traditional medicines (Ayurveda and Chinese traditional medicine) further support their efficacy and safe-for-humans claim.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::17b4bd9a3c9fc29399e4c20d9aa3ae9dTest
https://doi.org/10.1016/b978-0-12-819218-4.00016-xTest

المؤلفون: Eddiemar B. Lagua, Keiven Mark Ampode

المصدر: Journal of Animal Health and Production. 9

مصطلحات موضوعية: education.field_of_study, General Veterinary, medicine.drug_class, business.industry, Antibiotics, Population, Broiler, Biology, Antimicrobial, biology.organism_classification, chemistry.chemical_compound, chemistry, Bisdemethoxycurcumin, medicine, Curcumin, Animal Science and Zoology, Livestock, Food science, Curcuma, business, education

الوصف: The gradual increment of the human population resulted in an increased demand for animal protein in developing countries. To satisfy the need for animal protein, synthetic antibiotics were incorporated into broiler chickens’ diets to stimulate growth and rapidly increase production performance. This is a significant problem since the resistance of antimicrobial can be derived from antibiotics’ abusive usage. The antibiotic immunity is of great public health concern because the antibiotic-resistant bacteria linked with the animals may be infective to humans, easily transmitted through food chains to humans, and widely disseminated via animal waste in the environment. These can cause complex, which somehow prolonged human infections leading to higher healthcare costs and often death. There is an urgent need for the agricultural industry to develop strategies to substitute antibiotics for food-producing animals, especially poultry and livestock. Turmeric (Curcuma longa Linn.) is one of the many medicinal herbs promising agricultural products as natural feed additives in poultry diets. It is the primary source of phenolic compounds such as curcumin, bisdemethoxycurcumin, demethoxycurcumin, and tetrahydrocurcuminoids. Several trials of the utilization of turmeric in poultry have been conducted using the in vitro and in vivo methods, and it was found out that turmeric and its derivatives have antimicrobial properties. The use of turmeric powder as feed additives and supplements have been recommended as an alternative to antibiotics for broiler chicken production. The purpose of this review is to discuss the antimicrobial property of turmeric powder and its effect on broiler chicken in terms of performance and meat quality.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::f0453c4c56f7b3dcd57bb8dbaafab873Test
https://doi.org/10.17582/journal.jahp/2021/9.3.243.253Test

المؤلفون: Maria Teresa Conconi, Bianca Bazzolo, Raji Sundararajan, Ignacio G. Camarillo, Elisabetta Sieni, A. Piovan, Lakshya Mittal, R. Filippini

المصدر: Bioelectrochemistry (Amsterdam, Netherlands). 140

مصطلحات موضوعية: Electrochemotherapy, Curcumin, Biophysics, Intracellular Space, Antineoplastic Agents, Apoptosis, Breast Neoplasms, 02 engineering and technology, 01 natural sciences, chemistry.chemical_compound, Calcium Chloride, Breast cancer, Curcuminoids, Electricity, Cell Line, Tumor, Bisdemethoxycurcumin, Breast Cancer, Electrochemistry, medicine, Humans, Physical and Theoretical Chemistry, Cytotoxicity, Cellular localization, business.industry, 010401 analytical chemistry, Cancer, General Medicine, 021001 nanoscience & nanotechnology, medicine.disease, 0104 chemical sciences, Electroporation, chemistry, Cancer research, 0210 nano-technology, business

الوصف: Breast cancer is the most common cancer of women, and fifth leading cause of mortality worldwide. Existing breast cancer regimens are costly and produce severe side effects. This highlights a need for the development of efficient novel therapies, which are cost effective and limit side effects. An electrical pulse (EP)-based chemo therapy, known as electrochemotherapy (ECT) using the natural compound curcumin could be an effective alternative. ECT is a non-surgical modality, which produces excellent anti-tumor efficacy at small drug concentrations due to increased uptake of drugs. In clinics, ECT is shown to be effective in treating advanced, recurrent, and metastatic breast cancers, which are refractory to multiple modalities. ECT with curcumin triggers apoptotic cell death in breast cancer cells and could be an effective alternative, due to curcumin’s low cost and reduced side-effects. However, there is a lack of studies quantifying the uptake of curcumin in response to EP application. Towards this, we determined the uptake of different curcuminoids (curcumin, desmethoxycurcumin, and bisdemethoxycurcumin) upon EP application and their impact on cell cytotoxicity. Additionally, we studied the combined effect of calcium chloride (CaCl2) and a curcuminoids (Cur) mixture, based on initial studies suggesting calcium electroporation as a potential inexpensive anti-cancer treatment. Our results indicate EP with Cur increases cellular uptake, cell shrinkage, and cytotoxicity. The EP + Cur resulted in the highest uptake of the bisdemethoxycurcumin. Further, EP also potentiated the cytotoxicity of CaCl2 and of the Cur and CaCl2 combination against breast cancer cells and caused apoptosis. Our preliminary data pave the way to further studies on Cur and CaCl2 combination treating breast cancer.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f83bfa46553b0232cfefc6b15a6deffTest
https://pubmed.ncbi.nlm.nih.gov/33940353Test

المؤلفون: Yiwei Wang, Wenjing Zhu, Zhong Wang, Shao Yiqun, Jun Da, Mingxi Xu, Juan Zhou

المصدر: OncoTargets and therapy

مصطلحات موضوعية: PD-L1, 0301 basic medicine, medicine.medical_treatment, OncoTargets and Therapy, combination therapy, Metastasis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, Bisdemethoxycurcumin, medicine, metastasis, Pharmacology (medical), Original Research, Bladder cancer, biology, business.industry, bisdemethoxycurcumin, Immunotherapy, medicine.disease, Granzyme B, 030104 developmental biology, Oncology, chemistry, 030220 oncology & carcinogenesis, Cancer research, biology.protein, bladder cancer, immunotherapy, Antibody, business

الوصف: Yiqun Shao,1 Wenjing Zhu,2 Jun Da,1 Mingxi Xu,1 Yiwei Wang,1 Juan Zhou,1 Zhong Wang1 1Department of Urology, Shanghai Ninth People’s Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Urology, Yueyang Hospital of integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China Abstract: Curcumin was recently discovered to strengthen immune response through multiple mechanisms. Cytotoxic CD8+ T-cells play a critical role in modulating anticancer immune response, but is severely restricted by T-cell exhaustion. Bladder carcinomas express PD-L1 and can abrogate CD8+ T-cell response. Thus, we hypothesized that bisdemethoxycurcumin, a natural dimethoxy derivative of curcumin, may provide a favorable environment for T-cell response against bladder cancer when used in combination with α-PD-L1 antibody. Immunocompetent C56BL/6 mouse models bearing subcutaneous or lung metastasized MB79 bladder cancer were established to validate this conjecture. We found that bisdemethoxycurcumin significantly increased intratumoral CD8+ T-cell infiltration, elevated the level of IFN-γ in the blood, and decreased the number of intratumoral myeloid-derived suppressor cells. Furthermore, α-PD-L1 antibody protected these amplified CD8+ T-cells from exhaustion, and therefore facilitated the secretion of IFN-γ, granzyme B, and perforin through these CD8+ T-cells. As a result, this combination treatment strategy significantly prolonged survival of intraperitoneal metastasized bladder cancer bearing mice, suggesting that bisdemethoxycurcumin in combination with α-PD-L1 antibody may be promising for bladder cancer patients. Keywords: bladder cancer, immunotherapy, bisdemethoxycurcumin, PD-L1, combination therapy, metastasis

وصف الملف: text/html

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2befe098a54139093d1cd7fcafb8ffTest
https://doi.org/10.2147/ott.s130653Test

المؤلفون: Ming Xie, Zijian Xiao, Duanqun He, Yan Xu, Rundong Ma, Chenlin Xu, Heng Wu, Yilin Wang, Yunqian Chang, Bing He, Rong Hu, Guijuan Zhou, Lin Wu

مصطلحات موضوعية: chemistry.chemical_compound, chemistry, business.industry, Bisdemethoxycurcumin, medicine, Disease, Pharmacology, medicine.disease_cause, business, Oxidative stress

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fe8a36cdcc20b4b2eb9c2e973447e450Test
https://doi.org/10.1002/brb3.1655/v2/response1Test