Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET
| العنوان: | Binding characteristics of [18F]PI-2620 distinguish the clinically predicted tau isoform in different tauopathies by PET |
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| المؤلفون: | Jost-Julian Rumpf, Mengmeng Song, Günter U. Höglinger, Sibylle Ziegler, Guido Boening, Dorothee Saur, Gérard N. Bischof, John Seibyl, Kai Bötzel, Bernd Neumaier, Olivier Barret, Marianne Patt, Michael T. Barbe, Frank Jessen, Adrian Danek, Michael Rullmann, Gloria Biechele, Joseph Classen, Jochen Herms, Özgür A. Onur, Matthias Brendel, Peter Bartenstein, Leonie Beyer, Matthias L. Schroeter, Carla Palleis, Osama Sabri, Lena Kaiser, Jennifer Madonia, Sigrun Roeber, Maike Kern, Gesine Respondek, Maximilian Scheifele, Jochen Hammes, Ken Marek, Andrew W. Stephens, Andreas Schildan, Andre Mueller, Thilo van Eimeren, Alexander Nitschmann, Alexander Drzezga, Victor L. Villemagne, Johannes Levin, Henryk Barthel, David S. Russell |
| المصدر: | Journal of cerebral blood flow & metabolism 41(11), 2957-2972 (2021). doi:10.1177/0271678X211018904 Journal of Cerebral Blood Flow & Metabolism Journal of Cerebral Blood Flow and Metabolism |
| بيانات النشر: | Sage, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Gene isoform, Pathology, medicine.medical_specialty, Fluorine Radioisotopes, analysis [Protein Isoforms], binding, PI-2620, Neuroimaging, tau Proteins, methods [Image Interpretation, Computer-Assisted], Progressive supranuclear palsy, 03 medical and health sciences, 0302 clinical medicine, Image Interpretation, Computer-Assisted, diagnostic imaging [Tauopathies], medicine, Pi, Protein Isoforms, Humans, ddc:610, 030304 developmental biology, 0303 health sciences, business.industry, methods [Positron-Emission Tomography], Original Articles, medicine.disease, analysis [tau Proteins], ddc, Tauopathies, Neurology, Positron-Emission Tomography, kinetic modelling, affinity, Neurology (clinical), Radiopharmaceuticals, Tau, Cardiology and Cardiovascular Medicine, business, methods [Neuroimaging], 030217 neurology & neurosurgery |
| الوصف: | The novel tau-PET tracer [18F]PI-2620 detects the 3/4-repeat-(R)-tauopathy Alzheimer’s disease (AD) and the 4R-tauopathies corticobasal syndrome (CBS) and progressive supranuclear palsy (PSP). We determined whether [18F]PI-2620 binding characteristics deriving from non-invasive reference tissue modelling differentiate 3/4R- and 4R-tauopathies. Ten patients with a 3/4R tauopathy (AD continuum) and 29 patients with a 4R tauopathy (CBS, PSP) were evaluated. [18F]PI-2620 PET scans were acquired 0-60 min p.i. and the distribution volume ratio (DVR) was calculated. [18F]PI-2620-positive clusters (DVR ≥ 2.5 SD vs. 11 healthy controls) were evaluated by non-invasive kinetic modelling. R1 (delivery), k2 & k2a (efflux), DVR, 30-60 min standardized-uptake-value-ratios (SUVR30-60) and the linear slope of post-perfusion phase SUVR (9-60 min p.i.) were compared between 3/4R- and 4R-tauopathies. Cortical clusters of 4R-tau cases indicated higher delivery (R1SRTM: 0.92 ± 0.21 vs. 0.83 ± 0.10, p = 0.0007), higher efflux (k2SRTM: 0.17/min ±0.21/min vs. 0.06/min ± 0.07/min, p 30-60 (1.3 ± 0.2 vs. 1.8 ± 0.3, p 9-60: 0.006/min ± 0.007/min vs. 0.016/min ± 0.008/min, p 18F]PI-2620 binding characteristics in cortical regions differentiate 3/4R- and 4R-tauopathies. Higher tracer clearance indicates less stable binding in 4R tauopathies when compared to 3/4R-tauopathies. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0017620e70bd885f8bcefc995459a5d2Test https://pub.dzne.de/record/155560Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0017620e70bd885f8bcefc995459a5d2 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |