التفاصيل البيبلوغرافية
| العنوان: |
IgH partner breakpoint sequences provide evidence that AID initiates t(ll;14) and t(8;14) chromosomal breaks in mantle cell and Burkitt lymphomas. |
| المؤلفون: |
Greisman, Harvey A.1 greisman@uw.edu, Zhengfei Lu2,3,4, Tsai,, Albert G.2,5, Greiner, Timothy C.6, Hye Son Yi1, Lieber, Michael R.2,4 |
| المصدر: |
Blood. 10/4/2012, Vol. 120 Issue 14, p2864-2867. 4p. |
| مصطلحات موضوعية: |
*BURKITT'S lymphoma, *IMMUNOGLOBULIN H, *NUCLEOTIDE sequence, *CHROMOSOMES, *DEAMINASES, *CHROMOSOMAL translocation, *B cells |
| مستخلص: |
Previous studies have Implicated activation-induced cytidlne deaminase (AID) in B-cell translocations but have failed to identify any association between their chromosomal breakpoints and known AID target sequences. Analysis of 56 unclustered lgH-CCND1 transloca-tions in mantle cell lymphoma across the ~ 344-kb bcl-1 breakpoint locus dem-onstrates that half of the CCND1 breaks are near CpG dinucleotides. Most of these CpG breaks are at CGC motifs, and half of the remaining breaks are near WGCW, both known AID targets. These findings provide the strongest evidence to date that AID initiates chromosomal breaks in translocations that occur in human bone marrow B-cell progenitors. We also identify WGCW breaks at the MYC locus in Burkitt lymphoma translocations and mu-rine IgH-MYC translocations, both of which arise in mature germinal center B cells. Finally, we propose a developmen-tal model to explain the transition from CpG breaks in early human B-cell progeni-tors to WGCW breaks in later stage B cells. [ABSTRACT FROM AUTHOR] |
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