The molecular tweezer CLR01 inhibits Ebola and Zika virus infection
| العنوان: | The molecular tweezer CLR01 inhibits Ebola and Zika virus infection |
|---|---|
| المؤلفون: | Janis A. Müller, Markus Otto, Bernd Knöll, Mirja Harms, Camilla Frich Riber, Gal Bitan, Alexander N. Zelikin, Franziska Krüger, Annika Röcker, Christian Heid, Jan Münch, Sina Lippold, Alexandra Kupke, Judith Beer, Stephan Becker, Erik Dietzel, Jens von Einem, Andrea Sowislok, Jonas Schmidt-Chanasit, Thomas Schrader, Olli Vapalahti |
| المصدر: | Antiviral Research Röcker, A E, Müller, J A, Dietzel, E, Harms, M, Krüger, F, Heid, C, Sowislok, A, Riber, C F, Kupke, A, Lippold, S, von Einem, J, Beer, J, Knöll, B, Becker, S, Schmidt-Charnasit, J, Otto, M, Vapalahti, O, Zelikin, A N, Bitan, G, Schrader, T & Münch, J 2018, ' The molecular tweezer CLR01 inhibits Ebola and Zika virus infection ', Antiviral Research, vol. 152, pp. 26-35 . https://doi.org/10.1016/j.antiviral.2018.02.003Test Roecker, AE; Mueller, JA; Dietzel, E; Harms, M; Krueger, F; Heid, C; et al.(2018). The molecular tweezer CLR01 inhibits Ebola and Zika virus infection. ANTIVIRAL RESEARCH, 152, 26-35. doi: 10.1016/j.antiviral.2018.02.003. UCLA: Retrieved from: http://www.escholarship.org/uc/item/1jd1k01bTest |
| بيانات النشر: | eScholarship, University of California, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.disease_cause, Virus Replication, Zika virus, Ebola virus, Virus inactivation, Chlorocebus aethiops, ZikV Infection, 2.1 Biological and endogenous factors, Aetiology, Broadly active antiviral agents, Infectivity, biology, Zika Virus Infection, Pharmacology and Pharmaceutical Sciences, Ebolavirus, Organophosphates, 3. Good health, Infectious Diseases, Medical Microbiology, Ebola, Infection, Biotechnology, Bridged-Ring Compounds, Chemie, Antiviral Agents, Microbiology, Article, Cell Line, Vaccine Related, 03 medical and health sciences, Viral envelope, Microbicide, Virology, medicine, Animals, Humans, Vero Cells, Lipid rafts, Pharmacology, Prevention, Zika Virus, Hemorrhagic Fever, Ebola, biology.organism_classification, 030104 developmental biology, Emerging Infectious Diseases, Good Health and Well Being, Hemorrhagic Fever |
| الوصف: | Ebola (EBOV) and Zika viruses (ZIKV) are responsible for recent global health threats. As no preventive vaccines or antiviral drugs against these two re-emerging pathogens are available, we evaluated whether the molecular tweezer CLR01 may inhibit EBOV and ZIKV infection. This small molecule has previously been shown to inactivate HIV-1 and herpes viruses through a selective interaction with lipid-raft-rich regions in the viral envelope, which results in membrane disruption and loss of infectivity. We found that CLR01 indeed blocked infection of EBOV and ZIKV in a dose-dependent manner. The tweezer inhibited infection of epidemic ZIKV strains in cells derived from the anogenital tract and the central nervous system, and remained antivirally active in the presence of semen, saliva, urine and cerebrospinal fluid. Our findings show that CLR01 is a broad-spectrum inhibitor of enveloped viruses with prospects as a preventative microbicide or antiviral agent. Highlights • The molecular tweezer CLR01 inhibits EBOV and ZIKV infection. • ZIKV infection of cells derived from the anogenital tract and the central nervous system is blocked. • Anti-ZIKV activity is retained in semen, urine, saliva, and CSF. • CLR01 represents a broad-spectrum inhibitor of enveloped viruses with prospects as a microbicide or antiviral agent. |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d549c543645426132dc30e20cd3bfefTest https://escholarship.org/uc/item/1jd1k01bTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....5d549c543645426132dc30e20cd3bfef |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |