Formyl peptide receptor 1 up-regulation and formyl peptide receptor 2/3 down-regulation of blood immune cells along with defective lipoxin A4/resolvin D1 production in obstructive sleep apnea patients
| العنوان: | Formyl peptide receptor 1 up-regulation and formyl peptide receptor 2/3 down-regulation of blood immune cells along with defective lipoxin A4/resolvin D1 production in obstructive sleep apnea patients |
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| المؤلفون: | Chang-Chun Hsiao, Meng-Chih Lin, Yi-Xin Zheng, Mao-Chang Su, I-Chun Lin, Kuo-Tung Huang, Chia-Wei Liou, Yong-Yong Lin, Chien-Hung Chin, Yung-Che Chen, Po-Yuan Hsu, Ting-Ya Wang |
| المصدر: | PLoS ONE, Vol 14, Iss 5, p e0216607 (2019) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Neutrophils, Physiology, medicine.medical_treatment, Blood Pressure, NK cells, Vascular Medicine, Monocytes, White Blood Cells, 0302 clinical medicine, Animal Cells, Medicine and Health Sciences, Continuous positive airway pressure, Receptors, Lipoxin, Receptor, Sleep Apnea, Obstructive, Multidisciplinary, Respiration, Sleep apnea, Intermittent hypoxia, Middle Aged, Body Fluids, Lipoxins, Blood, medicine.anatomical_structure, Neurology, Breathing, Hypertension, Medicine, Female, Cellular Types, Anatomy, Research Article, medicine.medical_specialty, Docosahexaenoic Acids, Immune Cells, Science, Immunology, Formyl peptide receptor 1, Formyl peptide receptor 2, 03 medical and health sciences, Internal medicine, medicine, Humans, Blood Cells, business.industry, Monocyte, Biology and Life Sciences, Cell Biology, medicine.disease, Receptors, Formyl Peptide, nervous system diseases, respiratory tract diseases, Obstructive sleep apnea, Cross-Sectional Studies, 030104 developmental biology, Endocrinology, Gene Expression Regulation, Case-Control Studies, Sleep Disorders, Physiological Processes, business, 030217 neurology & neurosurgery |
| الوصف: | Background This study aims to investigate the role of FPR 1/2/3 expressions in patients with obstructive sleep apnea (OSA). Method We made cross-sectional comparisons of FPR1/2/3 expressions of blood neutrophil, M1/M2a monocyte, and natural killer (NK) cell between 16 healthy subjects (HS), 16 primary snoring (PS) subjects, 46 treatment-naive OSA patients, and 18 severe OSA patients under long-term continuous positive airway pressure treatment (severe OSA on CPAP). Results FPR1 expressions on neutrophil were increased in treatment-naive OSA and severe OSA on CPAP groups versus either HS or PS. FPR2 expressions on neutrophil were decreased in treatment-naive OSA versus HS, and returned to normal in severe OSA on CPAP group. FPR1/FPR2 expression ratio on neutrophil was increased in treatment-naive OSA versus either HS or PS. Serum lipoxin A4, resolvin D1 levels, and FPR3 expressions of M1, M2a and NK cells were all decreased in treatment-naive OSA versus HS. OSA patients with hypertension had decreased FPR2 expressions on neutrophil and FPR3 expressions of NK cell. FPR1 expression, FPR1/FPR2 expression ratio on neutrophil, and FPR3 expression of M1 cell were all reversed after > 6-month CPAP treatment in 9 selected patients. In vitro intermittent hypoxia with re-oxygenation treatment in THP-1 cells resulted in increased FPR1/FPR2 expression ratio of M1 cells, and increased FPR1/FPR3 expression ratio of M2a cells. Conclusions FPR1 over-expression and insufficiency of FPR2 and FPR3 in association with defective lipoxin A4 and resolving D1 production were associated with disease severity of OSA and its adverse consequences. |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d29657f31eae65ab6ad3668f8bb6e8beTest https://doi.org/10.1371/journal.pone.0216607Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d29657f31eae65ab6ad3668f8bb6e8be |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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