التفاصيل البيبلوغرافية
| العنوان: |
Early Stage Breast Cancer: Does Histologic Subtype (Ductal vs. Lobular) Impact 5 Year Overall Survival? |
| المؤلفون: |
Mubarak, Fatima1 (AUTHOR) fatima.mubarak@alumni.aku.edu, Kowkabany, Gabrielle2 (AUTHOR) gakowkabany@crimson.ua.edu, Popp, Reed3 (AUTHOR) reedpopp@ufl.edu, Bansal, Shivam4 (AUTHOR) shivambansal.sb8@gmail.com, Ahmed, Syeda Hoorulain5 (AUTHOR) hoorulain_ahmed97@hotmail.com, Sharan, Seema4 (AUTHOR) seemasharan2198@gmail.com, Sukniam, Kulkaew B.6 (AUTHOR) kulkaew.sukniam@duke.edu, Raikot, Swathi R.7 (AUTHOR) swathi.raikot@emory.edu, Jimenez, Paola Berrios8 (AUTHOR) paola.berrios2@upr.edu, Popp, Kyle9 (AUTHOR) kylelpopp@gmail.com, Manaise, Harsheen K.4 (AUTHOR) harsheen98@gmail.com, Gabriel, Emmanuel10 (AUTHOR) gabriel.emmanuel@mayo.edu |
| المصدر: |
Cancers. Apr2024, Vol. 16 Issue 8, p1509. 11p. |
| مصطلحات موضوعية: |
*BREAST cancer prognosis, *RESEARCH funding, *ACADEMIC medical centers, *EARLY detection of cancer, *BREAST tumors, *SYMPTOMS, *CANCER patients, *DESCRIPTIVE statistics, *EVALUATION of medical care, *KAPLAN-Meier estimator, *LOG-rank test, *CANCER chemotherapy, *SURVEYS, *RACE, *HISTOLOGICAL techniques, *DUCTAL carcinoma, *CONFIDENCE intervals, *OVERALL survival, *PROPORTIONAL hazards models, *REGRESSION analysis, *LOBULAR carcinoma |
| مستخلص: |
Simple Summary: The two major histological subtypes of breast cancer are ductal and lobular cancers. Histology impacts the biological behavior of breast cancer, so it is imperative to study its influence on the overall survival of breast cancer patients. The existing literature reports conflicting conclusions regarding the impact that histology might have on survival, so we aimed to study a large sample of patient data obtained from the National Cancer Database to determine if histology and several other clinical factors have an impact on the survival of early-stage breast cancer patients who have T1–T2 tumors, are clinically node-negative and have no metastatic activity. These results may help clinicians better understand the behaviors of different subtypes of breast cancer and will help them take a more tailored approach to breast cancer treatment. Histology is an important predictor of the behavior of breast cancer. We aim to study the impact of histology on the overall survival (OS) of breast cancer patients. We studied 11,085 breast cancer patients diagnosed with T1–T2 tumors, clinically node-negative and non-metastatic, from 2004 to 2019 included in the National Cancer Database. Kaplan–Meier curves, log-rank tests and Cox regression models were used to study the impact of histology and other variables on OS. In our patient population, 8678 (78.28%) had ductal cancer (IDC), while 2407 (21.71%) had lobular cancer (ILC). ILC patients were significantly more likely to be older, Caucasian, have a lower grade at diagnosis and be hormone receptor-positive compared to IDC patients. There was no statistically significant difference in the 5-year OS of early stage ductal (16.8%) and lobular cancer patients (16.7%) (p = 0.200). Patients of Hispanic and African American origin had worse OS rates compared to non-Hispanic and Caucasian patients, respectively. For node-positive disease, HER2+ tumors and triple-negative tumors, chemotherapy had a positive influence on OS (HR 0.85, 95% CI 0.77–0.93, p = 0.0012). Histology did not have a significant impact on the 5-year OS of early stage breast cancer patients. [ABSTRACT FROM AUTHOR] |
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