التفاصيل البيبلوغرافية
| العنوان: |
Disseminated tumor cells: Are they ready for clinical use? |
| المؤلفون: |
Braun, Stephan, Vogl, Florian D., Schneitter, Alois, Egle, Daniel, Auer, Doris, Lang, Margarete, Marth, Christian |
| المصدر: |
Breast; Apr2007 Supplement 2, Vol. 16, p51-54, 4p |
| مصطلحات موضوعية: |
TUMORS, CANCER cells, BONE marrow, STEM cells, CLINICAL trials, CROSSOVER trials |
| مستخلص: |
Abstract: During the past three decades, efforts successfully established the presence of disseminated tumor cells (DTC) in bone marrow as a prognostic factor. These works were comprehensively evaluated in a pooled analysis that now permits to classify the prognostic significance of DTC as level I evidence. Intriguing molecular data suggest a role for tumor stem cells possibly responsible for the prognostic impact of DTC. In a typical clinical setting of the year 2007, DTC—irrespectively of the strong prognostic significance—would only have a convincing clinical application if DTC were a surrogate marker for treatment efficacy. Consequently, this important question is to be addressed in well-designed clinical trials. [Copyright &y& Elsevier] |
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| قاعدة البيانات: |
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