Neurotrophin and Trk neurotrophin receptors in the inner ear of Salmo salar andSalmo trutta
| العنوان: | Neurotrophin and Trk neurotrophin receptors in the inner ear of Salmo salar andSalmo trutta |
|---|---|
| المؤلفون: | Maria Cristina Guerrera, S. Catania, Jonas Hannestad, Juan Represa, Antonino Germanà, F.J. Ochoa-Erena, R. Cabo, José A. Vega |
| المصدر: | Digital.CSIC. Repositorio Institucional del CSIC instname |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | inner ear, medicine.medical_specialty, Histology, animal structures, Blotting, Western, Salmo salar, Tropomyosin receptor kinase B, Receptors, Nerve Growth Factor, Tropomyosin receptor kinase A, Salmo salar andSalmo trutta, Tropomyosin receptor kinase C, Neurotrophin 3, Neurotrophic factors, Salmon, Internal medicine, medicine, Animals, Receptor, trkB, Inner ear, Receptor, trkC, Receptor, trkA, Molecular Biology, Ecology, Evolution, Behavior and Systematics, neurotrophin, biology, Brain-Derived Neurotrophic Factor, Cell Biology, Original Articles, Immunohistochemistry, Cell biology, medicine.anatomical_structure, Endocrinology, nervous system, Trk receptor, Ear, Inner, biology.protein, Saccule, sense organs, Anatomy, Developmental Biology, Neurotrophin |
| الوصف: | et al. Neurotrophins (NTs) and their signal transducing Trk receptors play a critical role in the development and maintenance of specific neuronal populations in the nervous system of higher vertebrates. They are responsible for the innervation of the inner ear cochlear and vestibular sensory epithelia. Neurotrophins and Trks are also present in teleosts but their distribution in the inner ear is unknown. Thus, in the present study, we used Western-blot analysis and immunohistochemistry to investigate the expression and cell localization of both NTs and Trk receptors in the inner ear of alevins of Salmo salar and Salmo trutta. Western-blot analysis revealed the occurrence of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), but not nerve growth factor (NGF), as well as all three Trk receptors, i.e. TrkA, TrkB and TrkC, the estimated molecular weights of which were similar to those expected for mammals. Specific immunoreactivity for neurotrophins was detected mainly in the sensory epithelia. In particular, BDNF immunoreactivity was found in the maculae of the utricle and saccule, whereas NT-3 immunoreactivity was present in the sensory epithelium of the cristae ampullaris. As a rule the sensory epithelia of the inner ear lacked immunoreactivity for Trks, thus excluding possible mechanisms of autocrinia and/or paracrinia. By contrast, overlapping subpopulations of neurons in the statoacoustic ganglion expressed TrkA (about 15%), TrkB (about 65%) and TrkC (about 45%). The present results demonstrate that, as in mammals and birds, the inner ear of teleosts expresses the components of the neurotrophin-Trk system, but their roles remain to be elucidated. © 2006 The Authors Journal compilation © 2006 Anatomical Society of Great Britain and Ireland. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e3f70f20c6ef71679fd9f9b75399d4eTest http://hdl.handle.net/11570/1704069Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....0e3f70f20c6ef71679fd9f9b75399d4e |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |