التفاصيل البيبلوغرافية
| العنوان: |
Computational modelling of the long-term effects of brain stimulation on the local and global structural connectivity of epileptic patients. |
| المؤلفون: |
Giannakakis, Emmanouil, Hutchings, Frances, Papasavvas, Christoforos A., Han, Cheol E., Weber, Bernd, Zhang, Chencheng, Kaiser, Marcus |
| المصدر: |
PLoS ONE; 2/6/2020, Vol. 15 Issue 2, p1-21, 21p |
| مصطلحات موضوعية: |
NETWORK effect, BRAIN stimulation, DIFFUSION |
| مستخلص: |
Computational studies of the influence of different network parameters on the dynamic and topological network effects of brain stimulation can enhance our understanding of different outcomes between individuals. In this study, a brain stimulation session along with the subsequent post-stimulation brain activity is simulated for a period of one day using a network of modified Wilson-Cowan oscillators coupled according to diffusion imaging based structural connectivity. We use this computational model to examine how differences in the inter-region connectivity and the excitability of stimulated regions at the time of stimulation can affect post-stimulation behaviours. Our findings indicate that the initial inter-region connectivity can heavily affect the changes that stimulation induces in the connectivity of the network. Moreover, differences in the excitability of the stimulated regions seem to lead to different post-stimulation connectivity changes across the model network, including on the internal connectivity of non-stimulated regions. [ABSTRACT FROM AUTHOR] |
|
Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder