The structural correlates of functional deficits in early huntington's disease
| العنوان: | The structural correlates of functional deficits in early huntington's disease |
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| المؤلفون: | Delmaire, Christine, Dumas, Eve M., Sharman, Michael A., van den Bogaard, Simon J.A., Valabregue, Romain, Jauffret, Céline, Justo, Damian, Reilmann, Ralf, Stout, Julie C., Craufurd, David, Tabrizi, Sarah J., Roos, Raymund A.C., Durr, Alexandra, Lehéricy, Stéphane |
| المساهمون: | Services de neuroradiologie [Lille], Hôpital Roger Salengro [Lille]-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Equipe NEMESIS - Centre de Recherches de l'Institut du Cerveau et de la Moelle épinière (NEMESIS-CRICM), Centre de Recherche de l'Institut du Cerveau et de la Moelle épinière (CRICM), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Service de génétique, cytogénétique, embryologie [Pitié-Salpétrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Pierre et Marie Curie - Paris 6 (UPMC), Department of neurology, Leiden University Medical Center (LUMC), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Universiteit Leiden-Universiteit Leiden, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| المصدر: | Human Brain Mapping Human Brain Mapping, Wiley, 2012, 34 (9), pp.2141-2153 ⟨10.1002/hbm.22055⟩ Human Brain Mapping, 2012, 34 (9), pp.2141-2153 ⟨10.1002/hbm.22055⟩ Hum Brain Mapp |
| بيانات النشر: | HAL CCSD, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Brain Mapping, Apathy, Brain, Huntington's disease, Middle Aged, Neuropsychological Tests, diffusion tensor imaging, Cognition, Diffusion Magnetic Resonance Imaging, Huntington Disease, nervous system, Image Interpretation, Computer-Assisted, [INFO.INFO-IM]Computer Science [cs]/Medical Imaging, Humans, Female, Cognition Disorders, VBM, Research Articles, Psychomotor Performance, MRI |
| الوصف: | International audience; Neuropathological studies in Huntington disease (HD) have demonstrated neuronal loss in the striatum, as well as in other brain regions including the cortex. With diffusion tensor MRI we evaluated the hypothesis that the clinical dysfunction in HD is related to regionally specific lesions of circuit-specific cortico-basal ganglia networks rather than to the striatum only. We included 27 HD and 24 controls from the TRACK-HD Paris cohort. The following assessments were used: self-paced tapping tasks, trail B making test (TMT), University of Pennsylvania smell identification test (UPSIT), and apathy scores from the problem behaviors assessment. Group comparisons of fractional anisotropy and mean diffusivity and correlations were performed using voxel-based analysis. In the cortex, HD patients showed significant correlations between: (i) self paced tapping and mean diffusivity in the parietal lobe at 1.8 Hz and prefrontal areas at 3 Hz, (ii) UPSIT and mean diffusivity in the parietal, and median temporal lobes, the cingulum and the insula, and fractional anisotropy in the insula and the external capsule, (iii) TMT B and mean diffusivity in the white matter of the superior frontal, orbital, temporal, superior parietal and post central areas, and (iv) apathy and fractional anisotropy in the white matter of the rectus gyrus. In the basal ganglia, we found correlations between the self paced tapping, UPSIT, TMT tests, and mean diffusivity in the anterior part of the putamen and the caudate nucleus. In conclusion, disruption of motor, associative and limbic cortico-striatal circuits differentially contribute to the clinical signs of the disease. Hum Brain Mapp, 2012. © 2012 Wiley Periodicals, Inc. |
| اللغة: | English |
| تدمد: | 1065-9471 1097-0193 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::69e230e57f69d87c983e3f9641282b0aTest https://hal.inria.fr/hal-00795703Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....69e230e57f69d87c983e3f9641282b0a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10659471 10970193 |
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