التفاصيل البيبلوغرافية
| العنوان: |
Acute thalamic connectivity precedes chronic post-concussive symptoms in mild traumatic brain injury. |
| المؤلفون: |
Woodrow, Rebecca E1,2 (AUTHOR) rw660@cam.ac.uk, Winzeck, Stefan1,3 (AUTHOR), Luppi, Andrea I1,2,4 (AUTHOR), Kelleher-Unger, Isaac R1,2 (AUTHOR), Spindler, Lennart R B1,2 (AUTHOR), Wilson, J T Lindsay5 (AUTHOR), Newcombe, Virginia F J1 (AUTHOR), Coles, Jonathan P1 (AUTHOR), Investigators, CENTER-TBI MRI Substudy Participants and (AUTHOR), Menon, David K1,6 (AUTHOR), Stamatakis, Emmanuel A1 (AUTHOR) |
| المصدر: |
Brain: A Journal of Neurology. Aug2023, Vol. 146 Issue 8, p3484-3499. 16p. |
| مصطلحات موضوعية: |
*POSTCONCUSSION syndrome, *BRAIN injuries, *THALAMIC nuclei, *GLASGOW Coma Scale, *FUNCTIONAL magnetic resonance imaging, *FUNCTIONAL connectivity |
| مستخلص: |
Chronic post-concussive symptoms are common after mild traumatic brain injury (mTBI) and are difficult to predict or treat. Thalamic functional integrity is particularly vulnerable in mTBI and may be related to long-term outcomes but requires further investigation. We compared structural MRI and resting state functional MRI in 108 patients with a Glasgow Coma Scale (GCS) of 13–15 and normal CT, and 76 controls. We examined whether acute changes in thalamic functional connectivity were early markers for persistent symptoms and explored neurochemical associations of our findings using PET data. Of the mTBI cohort, 47% showed incomplete recovery 6 months post-injury. Despite the absence of structural changes, we found acute thalamic hyperconnectivity in mTBI, with specific vulnerabilities of individual thalamic nuclei. Acute fMRI markers differentiated those with chronic post-concussive symptoms, with time- and outcome-dependent relationships in a sub-cohort followed longitudinally. Moreover, emotional and cognitive symptoms were associated with changes in thalamic functional connectivity to known serotonergic and noradrenergic targets, respectively. Our findings suggest that chronic symptoms can have a basis in early thalamic pathophysiology. This may aid identification of patients at risk of chronic post-concussive symptoms following mTBI, provide a basis for development of new therapies and facilitate precision medicine application of these therapies. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
