دورية أكاديمية
Anamnestic, clinical and laboratory features of the acute period of ischemic stroke in young patients
| العنوان: | Anamnestic, clinical and laboratory features of the acute period of ischemic stroke in young patients |
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| المؤلفون: | Gusev, V. V., Kovtun, O. P., Lvova, O. A., Partylova, E. A., Sergeev, A. P., Sergeeva, M. V., Yanchuk, I. T., Dobrazova, D. A., Suvorkov, P. A., Shamalov, N. A. |
| المصدر: | Nevrologiya, Neiropsikhiatriya, Psikhosomatika |
| بيانات النشر: | Ima-Press Publishing House |
| سنة النشر: | 2022 |
| المجموعة: | Ural Federal University (URFU): ELAR / Уральский федеральный университет: электронный архив УрФУ |
| مصطلحات موضوعية: | ISCHEMIC STROKE, RISK FACTORS, SINGLE NUCLEOTIDE SUBSTITUTIONS, THROMBOPHILIA, YOUNG AGE, ALPHA2 INTEGRIN, BETA3 INTEGRIN, BLOOD CLOTTING FACTOR 5, BLOOD CLOTTING FACTOR 7, FIBRINOGEN, FIBRINOGEN BETA, PLASMINOGEN ACTIVATOR INHIBITOR 1, UNCLASSIFIED DRUG, ADULT, ANAMNESIS, ARTICLE, ATHEROSCLEROTIC PLAQUE, ATRIAL FIBRILLATION, BRACHIOCEPHALIC ARTERY STENOSIS, BRAIN INFARCTION, BRAIN VASCULITIS, CEREBROVASCULAR MALFORMATION, CLINICAL FEATURE, COHORT ANALYSIS, COMPUTER ASSISTED TOMOGRAPHY, CONTROLLED STUDY, DNA POLYMORPHISM, DYSLIPOPROTEINEMIA, ERYTHROCYTE SEDIMENTATION RATE, FEMALE |
| الوصف: | Objective: to study the anamnestic, clinical and laboratory features of the acute period of ischemic stroke (IS) and to determine the risk factors for its development in young patients. Patients and methods. Clinical and statistical processing of data of 256 patients aged 18 to 44 years included, who had IS, confirmed by computed and/or magnetic resonance imaging of the brain in the acute period, was carried out. Furthermore, in 154 patients and in 117 healthy participants, who made up the control group, eight polymorphisms of the thrombophilic spectrum genes were determined – FGB: -455G>A, F2: 20210G>A, F5: 1691G>A, F7: 10976G>A, F13: 103 G>T, ITGA2: 807C>T, ITGB3: 1565 T>C, PAI-1: -675 5G>4G. Results and discussion. 154 (60.15%) patients demonstrated good recovery (achievement of a level of ≤2 points on the Rankin scale by the patient). None of the patients died during their hospitalization. In the evaluated group of patients, we identified allelic variants of the thrombophilic spectrum genes and gene-gene combinations, the carriage of which increased the likelihood of IS development at the young age by 1.74 and 2.19 times, respectively. Taking into consideration additional examination methods, the pathogenetic variant of IS according to the TOAST classification was verified in 226 (88%) patients. Conclusion. In IS at a young age a detailed assessment of risk factors is required, including an analysis of carrier variants and combinations of procoagulant and prothrombotic spectrum gene polymorphisms. © 2022 Ima-Press Publishing House. All rights reserved. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 20742711 |
| العلاقة: | Anamnestic, clinical and laboratory features of the acute period of ischemic stroke in young patients / V. V. Gusev, O. P. Kovtun, O. A. Lvova et al. // Nevrologiya, Neiropsikhiatriya, Psikhosomatika. — 2022. — Vol. 14. — Iss. 3. — P. 12-18.; https://www.scopus.com/inward/record.uri?eid=2-s2.0-85133840987&doi=10.14412%2f2074-2711-2022-3-12-18&partnerID=40&md5=5152e40847154e4cf4f307fd618cbfd1Test; http://elar.urfu.ru/handle/10995/117975Test; 85133840987 |
| DOI: | 10.14412/2074-2711-2022-3-12-18 |
| الإتاحة: | https://doi.org/10.14412/2074-2711-2022-3-12-18Test http://elar.urfu.ru/handle/10995/117975Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.7A2B4A38 |
| قاعدة البيانات: | BASE |
| تدمد: | 20742711 |
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| DOI: | 10.14412/2074-2711-2022-3-12-18 |