رسالة جامعية
Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior
| العنوان: | Group 2 innate lymphoid cells promote inhibitory synapse development and social behavior |
|---|---|
| المؤلفون: | Barron, Jerika J. |
| المساهمون: | Piao, Xianhua |
| بيانات النشر: | eScholarship, University of California |
| سنة النشر: | 2022 |
| المجموعة: | University of California: eScholarship |
| مصطلحات موضوعية: | Biology, Neurosciences, Brain development, IL-13, ILC2s, Inhibitory synapses, Neuroimmune |
| الوصف: | In early brain development, the formation and remodeling of neuronal synaptic connections is critical to forming functional neural circuits. The innate immune system plays essential roles in neurodevelopment, including in synapse remodeling, but the immune cells and signals that contribute are not well defined. Innate lymphocytes are the most recently discovered member of the innate immune arsenal, whose developmental expansion and activation make them potential mediators of brain-immune communication during synapse formation. Here we show that a subset of innate lymphocytes (group 2 innate lymphoid cells, ILC2s) populates the developing brain meninges and is required for cortical inhibitory synapse maturation and adult social behavior. ILC2s produced a surge of their canonical cytokine Interleukin 13 (IL-13) between postnatal days 5-15. Loss of ILC2s decreased cortical inhibitory synapse numbers in the postnatal period and led to impaired social recognition memory in adulthood. Postnatal administration of IL-13 or ILC2s into the brain ventricles was sufficient to drive an increase in inhibitory synapses. Deletion of the IL-4/IL-13 receptor (Il4ra) specifically from inhibitory neurons, but not myeloid cells, also reduced inhibitory synapses and impaired adult social behavior. These data define novel type 2 immune signaling that mediates lymphocyte-neuron communication in early life and shapes adult brain function. |
| نوع الوثيقة: | thesis |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | qt0js2s12x; https://escholarship.org/uc/item/0js2s12xTest; https://escholarship.org/content/qt0js2s12x/qt0js2s12x.pdfTest |
| الإتاحة: | https://escholarship.org/uc/item/0js2s12xTest https://escholarship.org/content/qt0js2s12x/qt0js2s12x.pdfTest |
| حقوق: | public |
| رقم الانضمام: | edsbas.31279F16 |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |