دورية أكاديمية
Remodeling of brain morphology in temporal lobe epilepsy.
| العنوان: | Remodeling of brain morphology in temporal lobe epilepsy. |
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| المؤلفون: | Roggenhofer, E., Muller, S., Santarnecchi, E., Melie-Garcia, L., Wiest, R., Kherif, F., Draganski, B. |
| المصدر: | Brain and behavior, vol. 10, no. 11, pp. e01825 |
| سنة النشر: | 2020 |
| المجموعة: | Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
| مصطلحات موضوعية: | Bayes Theorem, Brain/diagnostic imaging, Brain/pathology, Epilepsy, Temporal Lobe/diagnostic imaging, Functional Laterality, Hippocampus/diagnostic imaging, Hippocampus/pathology, Humans, Magnetic Resonance Imaging, Sclerosis/diagnostic imaging, Sclerosis/pathology, BMS, Bayesian model selection, MVB, computational anatomy, hippocampus, multivariate Bayesian modeling, temporal lobe epilepsy |
| الوصف: | Mesial temporal lobe epilepsy (TLE) is one of the most widespread neurological network disorders. Computational anatomy MRI studies demonstrate a robust pattern of cortical volume loss. Most statistical analyses provide information about localization of significant focal differences in a segregationist way. Multivariate Bayesian modeling provides a framework allowing inferences about inter-regional dependencies. We adopt this approach to answer following questions: Which structures within a pattern of dynamic epilepsy-associated brain anatomy reorganization best predict TLE pathology. Do these structures differ between TLE subtypes? We acquire clinical and MRI data from TLE patients with and without hippocampus sclerosis (n = 128) additional to healthy volunteers (n = 120). MRI data were analyzed in the computational anatomy framework of SPM12 using classical mass-univariate analysis followed by multivariate Bayesian modeling. After obtaining TLE-associated brain anatomy pattern, we estimate predictive power for disease and TLE subtypes using Bayesian model selection and comparison. We show that ipsilateral para-/hippocampal regions contribute most to disease-related differences between TLE and healthy controls independent of TLE laterality and subtype. Prefrontal cortical changes are more discriminative for left-sided TLE, whereas thalamus and temporal pole for right-sided TLE. The presence of hippocampus sclerosis was linked to stronger involvement of thalamus and temporal lobe regions; frontoparietal involvement was predominant in absence of sclerosis. Our topology inferences on brain anatomy demonstrate a differential contribution of structures within limbic and extralimbic circuits linked to main effects of TLE and hippocampal sclerosis. We interpret our results as evidence for TLE-related spatial modulation of anatomical networks. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | English |
| العلاقة: | info:eu-repo/semantics/altIdentifier/pmid/32945137; info:eu-repo/semantics/altIdentifier/eissn/2162-3279; info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_3FA1440B13BD9; https://serval.unil.ch/notice/serval:BIB_3FA1440B13BDTest; https://serval.unil.ch/resource/serval:BIB_3FA1440B13BD.P001/REF.pdfTest; http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_3FA1440B13BD9Test |
| DOI: | 10.1002/brb3.1825 |
| الإتاحة: | https://doi.org/10.1002/brb3.1825Test https://serval.unil.ch/notice/serval:BIB_3FA1440B13BDTest https://serval.unil.ch/resource/serval:BIB_3FA1440B13BD.P001/REF.pdfTest http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_3FA1440B13BD9Test |
| حقوق: | info:eu-repo/semantics/openAccess ; CC BY 4.0 ; https://creativecommons.org/licenses/by/4.0Test/ |
| رقم الانضمام: | edsbas.325FE324 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1002/brb3.1825 |
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