التفاصيل البيبلوغرافية
| العنوان: |
Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples. |
| المؤلفون: |
Prokop, Stefan, Miller, Kelly R., Labra, Sergio R., Pitkin, Rose M., Hoxha, Kevt'her, Narasimhan, Sneha, Changolkar, Lakshmi, Rosenbloom, Alyssa, Lee, Virginia M.-Y., Trojanowski, John Q. |
| المصدر: |
Acta Neuropathologica; Oct2019, Vol. 138 Issue 4, p613-630, 18p |
| مصطلحات موضوعية: |
NEUROFIBRILLARY tangles, ALZHEIMER'S patients, BRAIN diseases, GENE expression profiling, BRAIN, NEURONS |
| مستخلص: |
Identification of multiple immune-related genetic risk factors for sporadic AD (sAD) have put the immune system center stage in mechanisms underlying this disorder. Comprehensive analysis of microglia in different stages of AD in human brains revealed microglia activation to follow the progression of AD neuropathological changes and requiring the co-occurrence of beta-Amyloid (Aβ) and tau pathology. Carriers of AD-associated risk variants in TREM2 (Triggering receptor expressed on myeloid cells 2) showed a reduction of plaque-associated microglia and a substantial increase in dystrophic neurites and overall pathological tau compared with age and disease stage matched AD patients without TREM2 risk variants. These findings were substantiated by digital spatial profiling of the plaque microenvironment and targeted gene expression profiling on the NanoString nCounter system, which revealed striking brain region dependent differences in immune response patterns within individual cases. The demonstration of profound brain region and risk-variant specific differences in immune activation in human AD brains impacts the applicability of immune-therapeutic approaches for sAD and related neurodegenerative diseases. [ABSTRACT FROM AUTHOR] |
|
Copyright of Acta Neuropathologica is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
