المؤلفون: Sudre, Carole H, Van Wijnen, Kimberlin, Dubost, Florian, Adams, Hieab, Atkinson, David, Barkhof, Frederik, Birhanu, Mahlet A, Bron, Esther E, Camarasa, Robin, Chaturvedi, Nish, Chen, Yuan, Chen, Zihao, Chen, Shuai, Dou, Qi, Evans, Tavia, Ezhov, Ivan, Gao, Haojun, Girones Sanguesa, Marta, Gispert, Juan Domingo, Gomez Anson, Beatriz, Hughes, Alun D, Ikram, M Arfan, Ingala, Silvia, Jaeger, H Rolf, Kofler, Florian, Kuijf, Hugo J, Kutnar, Denis, Lee, Minho, Li, Bo, Lorenzini, Luigi, Menze, Bjoern, Molinuevo, Jose Luis, Pan, Yiwei, Puybareau, Elodie, Rehwald, Rafael, Su, Ruisheng, Shi, Pengcheng, Smith, Lorna, Tillin, Therese, Tochon, Guillaume, Urien, Hélène, van der Velden, Bas HM, van der Velpen, Isabelle F, Wiestler, Benedikt, Wolters, Frank J, Yilmaz, Pinar, de Groot, Marius, Vernooij, Meike W, de Bruijne, Marleen, ALFA study

المصدر: Medical Image Analysis , 91 , Article 103029. (2024)

مصطلحات موضوعية: Automated, Brain, CSVD, Challenge, Detection, Enlarged perivascular spaces, Lacunes, MRI, Microbleeds, Segmentation

الوصف: Imaging markers of cerebral small vessel disease provide valuable information on brain health, but their manual assessment is time-consuming and hampered by substantial intra- and interrater variability. Automated rating may benefit biomedical research, as well as clinical assessment, but diagnostic reliability of existing algorithms is unknown. Here, we present the results of the VAscular Lesions DetectiOn and Segmentation (Where is VALDO?) challenge that was run as a satellite event at the international conference on Medical Image Computing and Computer Aided Intervention (MICCAI) 2021. This challenge aimed to promote the development of methods for automated detection and segmentation of small and sparse imaging markers of cerebral small vessel disease, namely enlarged perivascular spaces (EPVS) (Task 1), cerebral microbleeds (Task 2) and lacunes of presumed vascular origin (Task 3) while leveraging weak and noisy labels. Overall, 12 teams participated in the challenge proposing solutions for one or more tasks (4 for Task 1-EPVS, 9 for Task 2-Microbleeds and 6 for Task 3-Lacunes). Multi-cohort data was used in both training and evaluation. Results showed a large variability in performance both across teams and across tasks, with promising results notably for Task 1-EPVS and Task 2-Microbleeds and not practically useful results yet for Task 3-Lacunes. It also highlighted the performance inconsistency across cases that may deter use at an individual level, while still proving useful at a population level.

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10181977/1/1-s2.0-S136184152300289X-main.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10181977Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10181977/1/1-s2.0-S136184152300289X-main.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10181977Test/

المؤلفون: Sampedro, Frederic, Stantonyonge, Nicole, Martínez-Horta, Saül, Alcolea, Daniel, Lleó, Alberto, Muñoz, Laia, Pérez-González, Rocío, Marín-Lahoz, Juan, Gómez-Ansón, Beatriz, Chico Ballesteros, Ana, Universitat Autònoma de Barcelona

مصطلحات موضوعية: Biomarkers, Brain, Diabetes mellitus, type 1, Hypoglycemia

الوصف: Altres ajuts: This work was financially supported by a grant from the SPANISH DIABETES SOCIETY. ; Impaired awareness of hypoglycemia (IAH) is a common complication in patients with type-1 diabetes (T1D). IAH is a major risk factor for severe hypoglycemic events, leading to adverse clinical consequences and cerebral damage. Non-invasive, cost-effective, and logistically efficient biomarkers for this condition have not been validated. Here, we propose plasma neurofilament light chain (NfL) levels as a biomarker of neuroaxonal damage in patients with T1D-IAH. 54 patients were included into the study (18 T1D-IAH, 18 T1D with normal awareness of hypoglycemia (NAH) and 18 healthy controls). We measured plasma NfL levels and studied cerebral gray matter alterations on MRI. We found that NfL levels were increased in patients with T1D-IAH compared with patients with T1D-NAH and healthy controls. Importantly, increased NfL levels correlated with reduced cerebral gray matter volume and increased IAH severity in patients with T1D-IAH. Overall, our findings identify plasma NfL levels as a potential biomarker of cerebral damage in this population, motivating further confirmatory studies with potential implications in clinical trials.

وصف الملف: application/pdf

العلاقة: BMJ open diabetes research and care; Vol. 8 (july 2020); https://ddd.uab.cat/record/227843Test; urn:10.1136/bmjdrc-2020-001516; urn:oai:ddd.uab.cat:227843; urn:pmid:32636221; urn:pmcid:PMC7342474; urn:pmc-uid:7342474; urn:oai:pubmedcentral.nih.gov:7342474; urn:oai:egreta.uab.cat:publications/64dd71e1-1c56-4455-8ba1-592c994c9857

الإتاحة: https://ddd.uab.cat/record/227843Test

المؤلفون: Hall, Deborah, Robertson, Erin, Shelton, Annie, Losh, Molly, Mila, Montserrat, Moreno, Esther, Gomez-Anson, Beatriz, Martínez-Cerdeño, Verónica, Grigsby, Jim, Lozano, Reymundo, Hagerman, Randi, Maria, Lorena, Berry-Kravis, Elizabeth, O'Keefe, Joan

المصدر: Cerebellum; Oct2016, Vol. 15 Issue 5, p578-586, 9p

مصطلحات موضوعية: BRAIN, RADIOGRAPHY, FRAGILE X syndrome, BRAIN imaging, NEUROBEHAVIORAL disorders, PHENOTYPES, GENETIC mutation, GENETICS

مستخلص: Fragile X-associated tremor/ataxia syndrome (FXTAS) is a progressive neurodegenerative disorder caused by a repeat expansion in the fragile X mental retardation 1 ( FMR1) gene. The disorder is characterized by kinetic tremor and cerebellar ataxia, shows age-dependent penetrance, and occurs more frequently in men. This paper summarizes the key emerging issues in FXTAS as presented at the Second International Conference on the FMR1 Premutation: Basic Mechanisms & Clinical Involvement in 2015. The topics discussed include phenotype-genotype relationships, neurobehavioral function, and updates on FXTAS genetics and imaging. [ABSTRACT FROM AUTHOR]

: Copyright of Cerebellum is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Murphy, Joseph M., Balan, Kottekkattu K., Toms, Andoni, Gomez-Anson, Beatriz, Lockwood, Martin

المصدر: AJNR Am J Neuroradiol

مصطلحات موضوعية: Adult, Male, Indium Radioisotopes, Granulomatosis with Polyangiitis, Brain, Antibodies, Monoclonal, Middle Aged, Magnetic Resonance Imaging, Meninges, Technetium Tc 99m Exametazime, Leukocytes, Humans, Female, Immunotherapy, Radiopharmaceuticals, Radionuclide Imaging, Aged, Antilymphocyte Serum

الوصف: BACKGROUND AND PURPOSE: Diffuse involvement of the meninges by remote granulomas in Wegener's granulomatosis is rare. This study reports the radiolabeled leucocyte imaging findings in five such patients. The diagnosis was made by MR imaging in five patients and confirmed in four by findings at meningeal biopsy. The potential role of serial radiolabeled leucocyte examinations in assessing treatment response is discussed. METHODS: Three of the five patients underwent whole-body planar (111)In-labeled leucocyte imaging. Two of these patients had serial imaging and one had, in addition, a (99m)Tc-HMPAO-labeled leucocyte single-photon emission CT brain examination. Two of the five patients had whole-body planar (99m)Tc-HMPAO-labeled leucocyte imaging. Of these, one patient had serial imaging. The radiolabeled leucocyte imaging findings were correlated with MR findings and with the patients' clinical course. RESULTS: In four patients there was a midline linear area of increased tracer uptake in the brain, and in one of these, tracer uptake also extended laterally over the brain convexity. In two patients linear tracer uptake extended in an inferolateral direction from the midline. These abnormalities correlated with meningeal thickening in the falx, over the brain convexity, and in the tentorium cerebelli on MR images. Serial imaging in three patients revealed a reduction or disappearance in tracer uptake after treatment with anti-CD52, which correlated with clinical improvement. CONCLUSION: In patients with Wegener's granulomatosis, abnormal uptake corresponding to meningeal thickening can be seen on planar radiolabeled leucocyte images. Leucocyte imaging may be useful for monitoring treatment response.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::7a094bfc9537a7cb3512225882cb7dfbTest
https://europepmc.org/articles/PMC7974063Test/

المؤلفون: Martínez-Horta, Saul^1,2,3,4 (AUTHOR), Moreu, Andrea⁵ (AUTHOR), Perez-Perez, Jesús^1,2,3,4,6 (AUTHOR), Sampedro, Frederic^1,2 (AUTHOR), Horta-Barba, Andrea^1,2,4 (AUTHOR), Pagonabarraga, Javier^1,2,3 (AUTHOR), Gomez-Anson, Beatriz^6,7 (AUTHOR), Lozano-Martinez, Gloria Andrea⁷ (AUTHOR), Lopez-Mora, Diego Alfonso⁸ (AUTHOR), Camacho, Valle⁸ (AUTHOR), Fernández-León, Alejandro⁸ (AUTHOR), Carrió, Ignasi⁸ (AUTHOR), Kulisevsky, Jaime^1,2,3,4,5,6 (AUTHOR) jkulisevsky@santpau.cat

المصدر: Parkinsonism & Related Disorders. Mar2019, Vol. 60, p92-97. 6p.

مصطلحات موضوعية: *HUNTINGTON disease, *NEUROLINGUISTICS, *CLINICAL epidemiology, *BILINGUALISM, *CINGULATE cortex, *RESPONSE inhibition, *BRAIN

مستخلص: Introduction: Bilingualism exerts neuroprotective effects against neurodegeneration. In Huntington's disease (HD), the systems involved in bilingual control show early compromise, but the effect of bilingualism on the course of HD is unknown.Methods: We addressed the impact of livelong use of bilingualism on the clinical features, brain structure and function in 30 early-mild stage HD patients. Using voxel-wise regression analysis, we explored the effect of levels of use of bilingualism on grey-matter volume (GMV) and 18F-FDG metabolism.Results: Higher use of bilingualism was associated with better performance in inhibitory control and set-shifting independently of age and education and with higher GMV in the inferior frontal gyrus. 18F-FDG data revealed a significant effect on multiple fronto-temporal regions, specifically, in the dorsal anterior cingulate cortex, the anterior insula, the ventromedial orbital prefrontal cortex and the inferior frontal gyrus. These changes contributed to better inhibitory control and set-shifting and to more preserved motor and functional capacity.Conclusion: In HD, lifelong use of bilingualism is associated with structural and metabolic brain changes that have an impact on cognition, movement and functionality. These findings highlight the importance of stimulating cognitive and brain reserve in HD and in other neurodegenerative conditions. [ABSTRACT FROM AUTHOR]