التفاصيل البيبلوغرافية
| العنوان: |
The Impact of Amyloid-β or Tau on Cognitive Change in the Presence of Severe Cerebrovascular Disease. |
| المؤلفون: |
Jang, Hyemin, Kim, Hee Jin, Choe, Yeong Sim, Kim, Soo-Jong, Park, Seongbeom, Kim, Yeshin, Kim, Ko Woon, Lyoo, Chul Hyoung, Cho, Hanna, Ryu, Young Hoon, Choi, Jae Yong, DeCarli, Charles, Na, Duk L., Seo, Sang Won, Sim Choe, Yeong, Woon Kim, Ko, Hyoung Lyoo, Chul, Hoon Ryu, Young, Won Seo, Sang, Alzheimer’s Disease Neuroimaging Initiative |
| المصدر: |
Journal of Alzheimer's Disease; 2020, Vol. 78 Issue 2, p573-585, 13p |
| مصطلحات موضوعية: |
CEREBRAL small vessel diseases, CEREBROVASCULAR disease, COGNITION disorders, ALZHEIMER'S disease, CEREBRAL amyloid angiopathy, BRAIN metabolism, BRAIN, RESEARCH, NERVE tissue proteins, RESEARCH methodology, RETROSPECTIVE studies, MAGNETIC resonance imaging, MEDICAL cooperation, EVALUATION research, SEVERITY of illness index, COMPARATIVE studies, PEPTIDES, LONGITUDINAL method |
| مستخلص: |
Background: As Alzheimer's disease (AD) and cerebral small vessel disease (CSVD) commonly coexist, the interaction between two has been of the considerable interest.Objective: We determined whether the association of Aβ and tau with cognitive decline differs by the presence of significant CSVD.Methods: We included 60 subcortical vascular cognitive impairment (SVCI) from Samsung Medical Center and 82 Alzheimer's disease-related cognitive impairment (ADCI) from ADNI, who underwent Aβ (florbetaben or florbetapir) and tau (flortaucipir, FTP) PET imaging. They were retrospectively assessed for 5.0±3.9 and 5.6±1.9 years with Clinical Dementia Rating-sum of boxes (CDR-SB)/Mini-Mental State Examination (MMSE). Mixed effects models were used to investigate the interaction between Aβ/tau and group on CDR-SB/MMSE changes.Results: The frequency of Aβ positivity (45% versus 54.9%, p = 0.556) and mean global FTP SUVR (1.17±0.21 versus 1.16±0.17, p = 0.702) were not different between the two groups. We found a significant interaction effect of Aβ positivity and SVCI group on CDR-SB increase/MMSE decrease (p = 0.013/p < 0.001), and a significant interaction effect of global FTP uptake and SVCI group on CDR-SB increase/MMSE decrease (p < 0.001 and p = 0.030). Finally, the interaction effects of regional tau and group were prominent in the Braak III/IV (p = 0.001) and V/VI (p = 0.003) not in Braak I/II region (p = 0.398).Conclusion: The association between Aβ/tau and cognitive decline is stronger in SVCI than in ADCI. Therefore, our findings suggested that Aβ positivity or tau burden (particularly in the Braak III/IV or V/VI regions) and CSVD might synergistically affect cognitive decline. [ABSTRACT FROM AUTHOR] |
|
Copyright of Journal of Alzheimer's Disease is the property of IOS Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
