Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI
| العنوان: | Non-invasive imaging of CSF-mediated brain clearance pathways via assessment of perivascular fluid movement with diffusion tensor MRI |
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| المؤلفون: | Harrison, Ian F, Siow, Bernard, Akilo, Aisha B, Evans, Phoebe G, Ismail, Ozama, Ohene, Yolanda, Nahavandi, Payam, Thomas, David L, Lythgoe, Mark F, Wells, Jack A |
| المصدر: | eLife, Vol 7 (2018) eLife |
| بيانات النشر: | eLife Sciences Publications Ltd, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, perivascular, QH301-705.5, glymphatic, Science, Short Report, Brain, cerebrospinal fluid, Rats, Sprague-Dawley, Diffusion Tensor Imaging, Imaging, Three-Dimensional, DTI, Rat, Animals, alzheimer's disease, Medicine, Biology (General), Human Biology and Medicine, Rheology, Neuroscience, MRI |
| الوصف: | The glymphatics system describes a CSF-mediated clearance pathway for the removal of potentially harmful molecules, such as amyloid beta, from the brain. As such, its components may represent new therapeutic targets to alleviate aberrant protein accumulation that defines the most prevalent neurodegenerative conditions. Currently, however, the absence of any non-invasive measurement technique prohibits detailed understanding of glymphatic function in the human brain and in turn, it’s role in pathology. Here, we present the first non-invasive technique for the assessment of glymphatic inflow by using an ultra-long echo time, low b-value, multi-direction diffusion weighted MRI sequence to assess perivascular fluid movement (which represents a critical component of the glymphatic pathway) in the rat brain. This novel, quantitative and non-invasive approach may represent a valuable biomarker of CSF-mediated brain clearance, working towards the clinical need for reliable and early diagnostic indicators of neurodegenerative conditions such as Alzheimer’s disease. eLife digest Our brain is bathed in cerebrospinal fluid, a clear liquid that ‘cushions’ the fragile organ. This liquid travels into the brain along special channels – the perivascular space – that surround certain blood vessels. As the fluid washes in and out of the brain, it takes with it potentially harmful molecules, such as the aggregates that build up to cause Alzheimer’s disease. If this brain-cleaning system becomes faulty, it could lead to neurodegenerative diseases. However, it is extremely difficult to measure the activity of this intricate and delicate system, and most studies so far have had to use invasive techniques that usually require brain surgery. Now, Harrison et al. adapt a technique, called diffusion tensor magnetic resonance imaging (MRI), to visualise how the cerebrospinal fluid moves in the perivascular space in healthy rats. The non-invasive MRI method captures how the cerebrospinal fluid is driven into the brain when the blood vessels nearby expand and contract; as the vessels pulsate with each heartbeat, there is a 300% increase in the movement of the fluid in the perivascular space. This approach could be applied to understand exactly how neurodegenerative diseases emerge when the cerebrospinal fluid stops to properly clean the brain. Ultimately, the method could be used to detect when the cleansing system starts to fail in people, which could help to treat patients before their brains accumulate too many harmful substances. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::1df1a9ca8606c03c37d7be3451389967Test https://elifesciences.org/articles/34028Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid.dedup....1df1a9ca8606c03c37d7be3451389967 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |