دورية أكاديمية
Comprehensive integration of single-cell transcriptomic data illuminates the regulatory network architecture of plant cell fate specification
| العنوان: | Comprehensive integration of single-cell transcriptomic data illuminates the regulatory network architecture of plant cell fate specification |
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| المؤلفون: | Shanni Cao, Xue Zhao, Zhuojin Li, Ranran Yu, Yuqi Li, Xinkai Zhou, Wenhao Yan, Dijun Chen, Chao He |
| المصدر: | Plant Diversity, Vol 46, Iss 3, Pp 372-385 (2024) |
| بيانات النشر: | KeAi Communications Co., Ltd., 2024. |
| سنة النشر: | 2024 |
| المجموعة: | LCC:Biology (General) LCC:Botany |
| مصطلحات موضوعية: | Arabidopsis, Single cell transcriptome, Gene regulatory network, Data integration, Plant cell atlas, Biology (General), QH301-705.5, Botany, QK1-989 |
| الوصف: | Plant morphogenesis relies on precise gene expression programs at the proper time and position which is orchestrated by transcription factors (TFs) in intricate regulatory networks in a cell-type specific manner. Here we introduced a comprehensive single-cell transcriptomic atlas of Arabidopsis seedlings. This atlas is the result of meticulous integration of 63 previously published scRNA-seq datasets, addressing batch effects and conserving biological variance. This integration spans a broad spectrum of tissues, including both below- and above-ground parts. Utilizing a rigorous approach for cell type annotation, we identified 47 distinct cell types or states, largely expanding our current view of plant cell compositions. We systematically constructed cell-type specific gene regulatory networks and uncovered key regulators that act in a coordinated manner to control cell-type specific gene expression. Taken together, our study not only offers extensive plant cell atlas exploration that serves as a valuable resource, but also provides molecular insights into gene-regulatory programs that varies from different cell types. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 2468-2659 |
| العلاقة: | http://www.sciencedirect.com/science/article/pii/S2468265924000477Test; https://doaj.org/toc/2468-2659Test |
| DOI: | 10.1016/j.pld.2024.03.008 |
| الوصول الحر: | https://doaj.org/article/28da028d00a44f8783f15994d35f8545Test |
| رقم الانضمام: | edsdoj.28da028d00a44f8783f15994d35f8545 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 24682659 |
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| DOI: | 10.1016/j.pld.2024.03.008 |