Efficacy and safety of once-monthly ibandronate treatment in patients with low bone mineral density – ESTHER study: 24 months of follow-up
| العنوان: | Efficacy and safety of once-monthly ibandronate treatment in patients with low bone mineral density – ESTHER study: 24 months of follow-up |
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| المؤلفون: | Katarina Simic-Pasalic, Study ESTHER |
| المصدر: | Srpski Arhiv za Celokupno Lekarstvo, Vol 140, Iss 11-12, Pp 722-727 (2012) |
| بيانات النشر: | National Library of Serbia, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Bone mineral, medicine.medical_specialty, ibandronat, business.industry, lcsh:R, Osteoporosis, lcsh:Medicine, General Medicine, medicine.disease, osteoporosis, Surgery, Therapy naive, Internal medicine, medicine, Lumbar spine, In patient, bone mineral density, Adverse effect, business, Prospective cohort study, bisphosphonates, Bone mass |
| الوصف: | Introduction. Osteoporosis is a major health and economic problem worldwide. The use of new drugs, such as ibandronate, is aimed at improving treatment of osteoporosis and currently poor compliance with BP therapy. Objective. To investigate efficacy and safety of ibandronate applied monthly, orally, in women with low bone mineral density (BMD). Methods. The prospective study was conducted in 34 centers in Serbia and included 77 women treated for 24 months with monthly ibandronate. The efficacy of treatment was assessed by change in bone mass values obtained by BMD measurement at the end of 24 months follow-up versus baseline and 12-months follow-up values. Compliance and safety, i.e. adverse effects (AE) were recorded. Results. Participants were postmenopausal (96%), osteoporotic (79.7%) females, diagnosed by lumbar spine DXA measurement (81%), with history of prior BP therapy in 33.8% women. The physical activity level significantly increased to the substantial level of activity (5.2% vs. 21.3%, p=0.003) during the study. After 12 and 24 months of treatment, BMD values significantly increased (p=0.002 and p |
| تدمد: | 2406-0895 0370-8179 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6fe13feec410306c11bbf2a046b481dTest https://doi.org/10.2298/sarh1212722sTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....f6fe13feec410306c11bbf2a046b481d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24060895 03708179 |
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